CAS: 22084-89-5; 3-(2-Methylphenyl)Propionic Acid

该化合物是一种芳香的碳酸衍生物,配有2-甲基苯基组的丙烯酸侧链,该化合物是有机合成的多用途中间体,特别是在制备药品,农用化学品和精细化学品方面,其结构主体对于在分子设计中引入脂利和消毒效应很有价值.苯基环上的甲基替代能增强稳定性和影响反应性,使其有选择性地发挥作用.该碳酸组允许进一步衍生,包括酯化,恐吓或减少.对于受控反应来说,它提供了一贯的纯性和与标准合成议定书的兼容性.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号939-57-1 (E)-3-(邻甲苯基)丙烯酸 | CAS号2373-76-4 邻甲基肉桂酸 | CAS号103-83-3 N,N-二甲基苄胺 | CAS号2495-35-4 丙烯酸苄酯 | CAS号3984-22-3 2-乙烯基-1,3-二氧戊环 | CAS号95-46-5 2-溴甲苯 | CAS号89-92-9 2-甲基苄基溴 | CAS号7363-85-1 3-(2-methyl-cyc... | CAS号104750-61-0 3-(邻甲苯基)丙酸乙酯 | CAS号4242-15-3 5-甲基-2-四氢萘酮 | CAS号923772-93-4 3-氯-4-甲基苯并[B]噻吩-2-羧酸 | CAS号24644-78-8 4-甲基-1-茚酮 | CAS号26465-81-6 3,3-二甲基-2,3-二氢-... | CAS号365554-24-1 2-Naphthaleneca... | CAS号14902-36-4 3-(邻甲苯基)丙-1-醇 | CAS号824-22-6 4-甲基-2,3-二氢-1H-茚 | CAS号90266-00-5 1-diazonio-4-(2... | CAS号61957-53-7 3,7-dimethyl-1H...

合成工艺路线路线简述

    📜2-甲基苄溴 反应生成2-甲基氢肉桂酸
    参考文献:3-甲基胆蒽的合成
    标题:3-甲基胆蒽的合成
    摘要:描述了一种3-甲基胆甾醇的新颖合成,其在操作上比当前使用的方法简单,并且可能适用于多种其他多环烃及其致癌代谢物的合成.
    Doi:10.1016/s0040-4039(01)90245-X

    海关参考信息

    专利信息


    专利号:US-7390801-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
    发明人:THORSETT EUGENE D; PLEISS MICHAEL A; LATIMER LEE H; JOHN VARGHESE; FREEDMAN STEPHEN; BRITTON THOMAS C; AUDIA JAMES A; REEL JON K; DRESSMAN BRUCE A; DROSTE JAMES J; HENRY STEVEN S; STUCKY RUSSELL D; PORTER WARREN J
    权利人:ATHENA NEUROSCIENCES INC; LILLY CO ELI
    摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

    专利号:US-2020149034-A1
    优先权日:2017-03-17
    标题:Methods and Compositions for Synthesis of Encoded Libraries

    专利号:US-2005009151-A1
    优先权日:2003-07-10
    标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
    发明人:CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
    权利人:PHARMACIA CORP
    摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

    专利号:US-9217012-B2
    优先权日:2009-04-08
    标题 :Inhibitors of protein tyrosine phosphatases
    发明人:ZHANG ZHONG-YIN; ZHANG SHENG
    权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
    摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

    专利号:US-7153847-B2
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds

    专利号:US-2005215541-A1
    优先权日:1996-12-23
    标题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds

    供应商参考报价(招募中)

    品牌试剂参考报价(招募中)

    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    主要参考文献

    [参考文献]: Holger Bühler, Et Al. Inversion Of Stereoselectivity By Applying Mutants Of The Hydroxynitrile Lyase From Manihot Esculenta. Chembiochem. 2005 Apr;6(4):711-7.

    合成参考文献


    摘要:Maison, W., Science of Synthesis Knowledge Updates, (2020) 1, 407.
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