CAS: 210992-85-1; 4-(Benzyloxy)-6-Chloropyrimidin-2-Amine

上下游产品

2-Amino-4,6-dichloropyrimidine benzyl alcohol [4-benzyloxy-6-(1-triisopropylsilanyl-1H-indol-4-yl)-pyrimidin-2-yl]-pyridin-3-yl-amine

📜2-氨基-4,6-二氯嘧啶置于sodium Hydride体系中,用 四氢呋喃,N,N-二甲基甲酰胺 用作溶剂,化学反应 1.5H,反应生成4-氯-6-(苯基甲氧基)-2-嘧啶胺
参考文献:Anti-Cancer Agents And Uses Thereof
标题:Anti-Cancer Agents And Uses Thereof
摘要:本发明涉及新化合物及其盐,它们的合成以及它们作为抗癌剂的用途.这些化合物包括式i的化合物: 和其溶剂化物,水合物和药用可接受盐,其中a 1 为n或cr 1 ;A 3 为n或cr 3 ;A 5 为n或cr 5 ;R 1,R 3-r 6 和l在说明书中有定义;N为0或1;X为在环部分具有6-10个碳的可选择取代芳基,在环部分具有1-3个氮原子的可选择取代的6元杂芳基,在环部分具有0-4个氮原子且可选择具有1个硫原子或1个氧原子的可选择取代的5元杂芳基,或者在其中6元环与5元环或6元环融合的可选择取代的杂芳基,其中在每种情况下1,2,3或4个环原子是从氮,氧和硫中独立选择的杂原子.它们对广泛范围的癌症,特别是白血病,非小细胞肺癌和结肠癌有效.

专利信息

专利号:US-6552018-B1
优先权日:1997-01-27
标 题:Pyrazole derivatives
发明人：EJIMA AKIO; OHSUKI SATORU; OHKI HITOSHI; NAITO HIROYUKI
权利人:DAIICHI SEIYAKU CO
摘要:The present invention relates to cis- and trans-forms of pyrazole derivatives, salts thereof, or agents containing the same, and represented by the general formula (I): n wherein G represents a nitrogen containing saturated heterocyclic structure represented by the following formula: n These compounds exhibit anti-tumor activity on 5-FU-resistant tumors and effects on P glycoprotein expressing, multiple-drug resistant tumors. An example of a pyrazole derivative which demonstrates 50% inhibition of tumor cell growth is 3-[4-(3-chloro-5-fluorophenyl)- 1 piperazinyl]-1-[1-(3-chloro-2-pyridyl)-5-methyl-4-pyrazolyl)-1-trans-propene hydrochloride. Synthesis of the compounds represented by formula (I) can be prepared by any one of various routes such as a Mannich reaction, a Wittig reaction, reductive amination or substitution by allylation.