CAS: 17827-61-1; Methyl 1-Methylpyrazole-3-Carboxylate

相似化合物

25016-20-0 27258-32-8 84547-62-6

上下游产品

1-甲基吡唑-3-甲酸 1-Methylpyrazole-3-Carboxylic Acid 25016-20-0
吡唑-3-羧酸甲酯 Methyl 1H-Pyrazole 3-Carboxylate 15366-34-4
吡唑-3-甲酸 1H-Pyrazole-3-Carboxylic Acid 1621-91-6

1,3-二甲基吡唑置于氢氧化钾,Potassium Permanganate体系中,用 水,N,N-二甲基甲酰胺 用作溶剂,化学反应 50.0H,反应生成1-甲基-1H-吡唑-3-羧酸甲酯
参考文献:假单宁酸的化学.第14部分.杂环基取代的恶唑衍生物的合成和体内生物活性.
标题:假单宁酸的化学.第14部分.杂环基取代的恶唑衍生物的合成和体内生物活性.
摘要:已制备了含有杂环基取代的恶唑的假单酸a的半合成类似物.杂环为噻吩,呋喃,吡啶或异恶唑的衍生物显示出非常好的抗菌效力,并在体内进行了进一步评估.药代动力学参数和针对实验性腹膜内脓毒症的口服活性均优于从先前描述的假单酸a衍生物获得的结果.
Doi:10.7164/antibiotics.48.1336

专利信息

专利号:EP-3686190-A1
优先权日:2013-07-11
标 题 :Synthesis of therapeutically active compounds

专利号:US-12103929-B2
优先权日:2018-06-25
标题:Tricyclic compounds
发明人：FANG HAIQUAN; CHEN MINGMING; YANG GUIQUN; DU YUELEI; WANG YANPING; WU TONG; LI QINGLONG; ZHANG LEI; HU SHAOJING
权利人:JACOBIO PHARMACEUTICALS CO LTD
摘要:Disclosed are tricyclic compounds as bromodomain and extra-terminal (BET) inhibitors which are shown as formula I, their synthesis and their use for treating diseases. More particularly, disclosed are fused heterocyclic derivatives useful as inhibitors of BET, methods for producing such compounds and methods for treating diseases and conditions wherein inhibition of one or more BET bromodomains provides a benefit.