专利号:WO-03080621-A1 优先权日:2002-03-19 标题:Process and intermediates to substituted imidazopyrimidines 发明人:LI WENJIE; CAI DONGWEI; HOERRNER R SCOTT; JENSEN MARK S; LARSEN ROBERT D; PETASIS NICOS A 权利人:MERCK & CO INC; LI WENJIE; CAI DONGWEI; HOERRNER R SCOTT; JENSEN MARK S; LARSEN ROBERT D; PETASIS NICOS A 摘要:A novel process is provided for the preparation of imidazo[1,2-α]pyrimidines which are substituted at the 3-position with a substituted chlorophenyl group. Such compounds are useful in the synthesis of GABAA receptor ligands for the treatment of deleterious mental disorders. Also provided are intermediates obtained from the process useful in the synthesis of GABAA receptor ligands.
专利号:US-6531470-B1 优先权日:1998-01-23 标题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:US-6562844-B2 优先权日:1998-01-23 标 题:Oxazolidinone combinatorial libraries, compositions and methods of preparation 发明人:GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; NI ZHI-JIE; GORDON ERIC 权利人:UPJOHN CO 摘要:Oxazolidinones and methods for their synthesis are provided. Also provided are combinatorial libraries comprising oxazolidinones, and methods to prepare the libraries. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. The methods of library preparation include the attachment of oxazolidinones to a solid support. The methods of compound preparation in one embodiment involve the reaction of an iminophosphorane with a carbonyl containing polymeric support.
专利号:EP-0693072-B9 优先权日:1993-04-08 标题 :Method for the synthesis of 4- and/or 5-(di)substituted 2-aminoimidazoles from 2-aminoimidazoles and aldehydes
专利号:CN-117660376-A 优先权日:2022-09-08 标题 :A mutant of N-oxygenase used for the synthesis of 2-nitroimidazole and its application
专利号:EP-0693072-A4 优先权日:1993-04-08 标 题 :PROCESS FOR THE SYNTHESIS OF 2-AMINOIMIDAZOLES (BI) SUBSTITUTED IN POSITION 4 and / or 5 FROM 2-AMINOIMIDAZOLES AND ALDEHYDES