CAS: 143879-80-5; 2,3,4-Trifluorobenzonitrile

相似化合物

61079-72-9 161793-17-5 773-82-0

上下游产品

2,3,4,-trifluorobenzoic acid 2,3,4-trifluorobenzamide 2,3,4-trifluoro-benzoyl chloride (2,3,4-trifluorophenyl)methanamine 2-(6-cyano-2,3-difluorophenyl)malonic acid diethyl ester 6,7-difluoro-1H-indazole-3-amine 4-(4-Cyano-2,3-difluoro-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

2,3,4-三氟苯甲酰氯置于ammonium Hydroxide,三氯氧磷体系中,用 氯仿 用作溶剂,化学反应 2.0H,反应生成2,3,4-三氟苯甲腈
参考文献:合成和评估敏感的基于香豆素的荧光底物,通过基于液滴的筛选发现α-N-乙酰半乳糖苷酶
标题:合成和评估敏感的基于香豆素的荧光底物,通过基于液滴的筛选发现α-N-乙酰半乳糖苷酶
摘要:为了寻找用于基于液滴的α-N-乙酰半乳糖苷酶微滴筛选分析底物的一部分,对一系列香豆素衍生物的光谱和物理特性进行了测量.从这些新的基于香豆素的荧光团中,我们选择了具有最佳特性的jericho Blue.然后开发了一种可靠的方法,用于挑战性合成α-Galnac香豆素苷,并通过9个实例进行了证明.以这种方式制备的耶利哥蓝的α-Galnac糖苷在筛选条件下显示出非常好的功能.
Doi:10.1039/d0Ob02484H

专利信息

专利号:US-2009264680-A1
优先权日:2004-07-07
标题:Process for the synthesis and purification of (4-methoxybutyl) (4-trifluoromethylphenyl) methanone
发明人：CASTELLIN ANDREA; GREGORI LUCA; GONZALES TRUEBA GUADALUPE; RUBELLO ALBINO; NICOLE ANDREA
权利人:CASTELLIN ANDREA; GREGORI LUCA; GONZALES TRUEBA GUADALUPE; RUBELLO ALBINO; NICOLE ANDREA
摘要:A process for the preparation of 4-trifluoromethylvalerophenone is described. The process described is a three step process comprising the synthesis of organomagnesium specie, coupling reaction between the organomagnesium specie and trifluoromethylbenzonitrile or trifluoromethylbenzoyl chloride and preferably a purification of the product obtained in suitable reaction conditions. In the process an extraction phase of the final product is not required.

专利号:WO-9731891-A1
优先权日:1996-03-01
标 题:Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
发明人：LYNCH JOSEPH E; SHI YAO-JUN; WELLS KENNETH M
权利人:MERCK & CO INC; LYNCH JOSEPH E; SHI YAO JUN; WELLS KENNETH M
摘要:The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.

专利号:US-5777123-A
优先权日:1996-03-01
标题 :Process for regioselective substitution of trifluorobenzoate or trifluorobenzonitrile
发明人：LYNCH JOSEPH E; SHI YAO-JUN; WELLS KENNETH M
权利人:MERCK & CO INC
摘要:The invention provides a process for regioselective substitution of trifluorobenzoate/trifluorobenzonitrile to afford the difluorobenzoate/difluorobenzonitrile in good yields. The resulting difluorobenzoate/difluorobenzonitrile can again be regioselectively substituted with a second nucleophile to give monofluorobenzoate/monofluorobenzonitrile also in good yields. This process is particularly useful for forming key intermediates in the synthesis of oxytocin antagonist compounds.

专利号:US-10745342-B2
优先权日:2018-07-05
标 题 :Synthesis method of 2,4,6-trifluorobenzylamine
发明人：YUAN QILIANG; QIAN JIE; LAI XIN; CHEN HAIFENG; CHEN YINHAO; WANG CHAO
权利人:ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD; SHAOXING ZHONGKE BAIYUN CHEMICAL TECH CO LTD
摘要:The disclosure provides a synthesis method of 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis. The synthesis method is characterized by comprising the following steps: (1) allowing pentachlorobenzonitrile as a raw material to undergo fluoridation reaction with a fluoridation agent based on 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzonitrile with hydrogen in the presence of organic carboxylic acid, based, on palladium carbon as a catalyst to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzylamine with hydrogen in a solvent in the presence of a catalyst to obtain 2,4,6-trifluorobenzylamine. The synthesis method has the advantages of low raw material cost, short reaction steps, high reaction yield, good product purity simple operation and the like, and is suitable for industrial production.

专利号:JP-2010222357-A
优先权日:2002-03-11
标题 :Intermediate compounds for the synthesis of aminoindazole derivatives

专利号:JP-5315287-B2
优先权日:2002-03-11
标 题 :Intermediate compounds for the synthesis of aminoindazole derivatives