CAS: 122775-35-3; 3,4-Dimethoxyphenylboronic Acid

该化合物是一种含有苯环上角氧替代物的碳酸衍生物,该化合物在铃木-宫浦交叉反应中被广泛用作关键中间体,能够以高度选择性和效率合成双子体结构,其稳定性和反应性使其适合制药和农用化学应用,特别是在制造复杂分子时.对甲基氧的电饱和性能组增强了其与各种催化剂的兼容性,提高了产量和反应条件.此外,该化合物还被用于设计有机电子部件的材料科学中.该产品通常作为白色向非白晶状的高纯度粉供应,确保合成工作流程的一贯性能.

结构式图片

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365564-10-9 182344-21-4 622864-48-6

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合成工艺路线路线简述

    3,4-二甲氧基苯胺置于盐酸,Sodium Nitrite,四羟基二硼体系中,用 甲醇,水 用作溶剂,化学反应 1.5H,以65%的收率获得3,4-二甲氧基苯硼酸
    参考文献:Methanol-Promoted Borylation Of Arylamines: A Simple And Green Synthetic Method To Arylboronic Acids And Arylboronates
    标题:Methanol-Promoted Borylation Of Arylamines: A Simple And Green Synthetic Method To Arylboronic Acids And Arylboronates
    摘要:A Sandmeyer Borylation Of Arylamines Via A Sn2Ar Pathway Promoted By Methanol With Sodium Nitrite And Hydrochloric Acid As Diazotization Agent Has Been Developed,Which Provide A Simple And Green Synthetic Method To Arylboronic Acids And Arylboronates.
    Doi:10.1055/s-0033-1339118

    海关参考信息

    专利信息


    专利号:US-2006287529-A1
    优先权日:2003-02-20
    标 题:Solid phase synthesis of antitumoral compounds
    发明人:ALVAREZ MERCEDES; ALBERICIO FERNANDO; CIRONI PABLO; CUE VAS CARMEN; FRANCESCH ANDREAS; MARFIL MARTA
    权利人:ALVAREZ MERCEDES; ALBERICIO FERNANDO; CIRONI PABLO; CUE VAS CARMEN; FRANCESCH ANDREAS; MARFIL MARTA
    摘要:Lamellarins are prepared using a solid phase synthesis. In a first aspect, the process includes a step as follows: Formula (I) where R 1 to R 15 are as defined, and X is halogen, provided that one of R 2 , R 3 or R 4 is immobilised to a resin. In a second aspect, the process includes a step as follows: Formula (II) where R 1 ′ to R 5 ′, R 11 ′ and R 13 ′ are as defined, X 1 and X 2 are halogen, M is a metal function and PG is an amino protecting group, provided that one of that R 2 ′, R 3 ′ or R 4 ′ is immobilised to a resin.

    专利号:US-9085511-B2
    优先权日:2011-04-04
    标题:Atropisomeric 1,8-bisphenolnapthalenes and their use in enantioselective recognition and asymmetric synthesis
    发明人:WOLF CHRISTIAN; GHOSN MARWAN
    权利人:WOLF CHRISTIAN; GHOSN MARWAN; UNIV GEORGETOWN
    摘要:This invention related to atropisomeric 1,8-bisphenolnaphthalenes and derivatives thereof of the general formula (I): n nwhich are useful in resolution of enantiomers, enantioselective recognition and asymmetric synthesis.

    专利号:US-2023365629-A1
    优先权日:2018-06-15
    标题:Synthesis of echinocandin antifungal agent

    专利号:EP-1836163-B1
    优先权日:2004-12-23
    标题 :Pyrrolidine derivatives for the treatment of a disease depending on the activity of renin
    发明人:BREITENSTEIN WERNER; COTTENS SYLVAIN; EHRHARDT CLAUS; JACOBY EDGAR; LORTHIOIS EDWIGE LILIANE JEANNE; MAIBAUM JUERGEN KLAUS; OSTERMANN NILS; SELLNER HOLGER; SIMIC OLIVER
    权利人:NOVARTIS AG
    摘要:Novel 3-mono-, 3,4-di- and 3,4,4,-tri-substituted pyrrolidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on inappropriate activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on inappropriate activity of renin; the use of a compound of that class in the treatment of a disease that depends on inappropriate activity of renin; pharmaceutical formulations comprising a said substituted pyrrolidine compound, and/or a method of treatment comprising administering a said substituted pyrrolidine compound, a method for the manufacture of said substituted pyrrolidine compounds, and novel intermediates and partial steps for their synthesis are described. The substituted pyrrolidine compounds are especially of the formula I wherein the substituents are as described in the specification.

    专利号:EP-1613635-A2
    优先权日:2003-02-20
    标题 :Solid phase synthesis of antitumoral compounds

    专利号:US-11524980-B2
    优先权日:2018-06-15
    标 题 :Synthesis of echinocandin antifungal agent
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    📌 第三方产品分析报告

    ✅ COA系统入驻 | 共享模式

    合成参考文献


    摘要:Yoshikai, N.; Rayner, C. M.; Graham, M. A., Science of Synthesis Knowledge Updates, (2020) 2, 79.
    摘要:Tomé, A. C., Science of Synthesis Knowledge Updates, (2015) 2, 89.
    摘要:Sato, N., Science of Synthesis Knowledge Updates, (2011) 4, 293.
    摘要:Beier, P., Science of Synthesis Knowledge Updates, (2014) 2, 307.
    摘要:Guram, A. S.; Milne, J. E.; Tedrow, J. S.; Walker, S. D., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 1, 102.
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