CAS: 119240-82-3; (S)-5,7-Dihydroxy-2-(4-Hydroxy-3-(3-Methylbut-2-En-1-yl)Phenyl)Chroman-4-One

该化合物是一种主要来自乳胶厂的氟氯素化合物,以其潜在的健康惠益和生物活动著称;它具有抗氧化性特性,有助于中和自由基和减少生物系统中的氧化压力;利科法洛酮的特点是其多酚结构,有助于其与包括酶和受体在内的各种生物目标进行互动的能力;该化合物的抗炎和抗癌效应已经研究过,因此对药理学研究感兴趣;此外,利科法洛酮可能具有抗微生物特性,有助于其在天然产品配方中的潜在用途;其溶解性和稳定性可以因溶剂和环境条件而不同而不同,这对于在研究和治疗环境中的应用都很重要;

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    上下游产品

    2-methyl-3-buten-2-ol naringenin 3,3-dimethylallyl diphosphate triammonium salt

    合成工艺路线路线简述

      📜Dmapp,(S)-柚皮素置于fungal Prenyltransferase Anapt,Calcium Chloride体系中,用 二甲基亚砜,甘油 用作溶剂,化学反应 16.0H,以54.2%的收率获得3'-异戊烯基柚皮素
      参考文献:Complementary Flavonoid Prenylations By Fungal Indole Prenyltransferases
      标题:Complementary Flavonoid Prenylations By Fungal Indole Prenyltransferases
      摘要:Flavonoids Are Found Mainly In Plants And Exhibit Diverse Biological And Pharmacological Activities,Which Can Often Be Enhanced By Prenylations. In Plants,Such Reactions Are Catalyzed By Membrane-Bound Prenyltransferases. In This Study,The Prenylation Of Nine Flavonoids From Different Classes By A Soluble Fungal Prenyltransferase (Anapt) Involved In The Biosynthesis Of The Prenylated Indole Alkaloid Acetylaszonalenin Is Demonstrated. The Behavior Of Anapt Toward Flavonoids Regarding Substrate Acceptance And Prenylation Positions Clearly Differs From That Of The Indole Prenyltransferase 7-Dmats. The Two Enzymes Are Therefore Complementary In Flavonoid Prenylations.
      Doi:10.1021/acs.Jnatprod.5B00422

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      ✅ COA系统入驻 | 共享模式

      合成参考文献


      摘要:Peng JY, Fan GR, Wu YT. [Isolation and structure identification of chemical constituents from Patrinia villosa]. Yao Xue Xue Bao. 2006 Mar;41(3):236–40.
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