CAS: 1128-61-6; 6-Fluoro-2-Methylquinoline

相似化合物

1128-74-1 46001-36-9 1128-74-1

上下游产品

CAS号877-42-9 6-溴-2-甲基喹啉 | CAS号199186-69-1 (R)-6-FLUORO-2-... | CAS号75-07-0 乙醛 | CAS号371-40-4 4-氟苯胺 | CAS号42835-89-2 6-氟-1,2,3,4-四氢-... | CAS号64-17-5 乙醇 | CAS号109-92-2 乙烯基乙醚 | CAS号123-73-9 2-丁烯醛 | CAS号350-46-9 对氟硝基苯 | CAS号42835-89-2 6-氟-1,2,3,4-四氢-... | CAS号143703-35-9 6-fluoro-2,5-di... | CAS号91-63-4 2-甲基喹啉 | CAS号1220450-27-0 2-methyl-6-(4-t... | CAS号260430-93-1 6-氟喹啉-2-甲醛 | CAS号124858-35-1 那氟沙星 | CAS号124050-15-3 2-(chloromethyl... | CAS号199186-69-1 (R)-6-FLUORO-2-... | CAS号199186-68-0 (S)-6-FLUORO-2-... | CAS号80290-18-2 5-溴-6-氟-2-甲基喹啉

(R)-6-Fluoro-2-Methyl-1,2,3,4-Tetrahydroquinoline置于cobalt(II) Acetate Air,丙酸,Sodium Bromide体系中,120.0~140.0 °C,800.0 Kpa 条件下,反应 8.0H,反应生成6-氟-2-甲基喹啉
参考文献:Unusual Phenomena During The Resolution Of 6-Fluoro-2-Methyl-1,2,3,4-Tetrahydroquinoline (Fthq): Thermodynamic-Kinetic Control
标题:Unusual Phenomena During The Resolution Of 6-Fluoro-2-Methyl-1,2,3,4-Tetrahydroquinoline (Fthq): Thermodynamic-Kinetic Control
摘要:6-Fluoro-2-Methyl-1,2,3,4-Tetrahydroquinoline (Fthq) Was Resolved In Several Different Solvents By Tartaric Acid Derivatives As The Most Common Acidic Resolving Agents Available In Industrial Quantities. Strong Reaction Kinetics And Solvent Dependence Were Observed,Curiously Without Solvation. In Possession Of These Findings,An Economic Resolution Process Is Proposed,Which Is Completed By The Incorporation Of A Racemization Step. (C)C 2002 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0957-4166(02)00021-6

专利信息

专利号:US-11795168-B2
优先权日:2020-09-23
标 题:Inhibiting cyclic amp-responsive element-binding protein (CREB) binding protein (CBP)
发明人：LUKE GEORGE; BABU SURESH
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to solid and salt forms of inhibitors of the CBP/p300 family of bromodomains made up of salts and crystalline forms of Formula (I). The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.

专利号:US-12378242-B2
优先权日:2018-06-29
标题 :Inhibiting CREB binding protein (CBP)
发明人：SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST Angela; DOWNING JENNIFER R; ERICSSON ANNA
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

专利号:US-11787803-B2
优先权日:2017-09-15
标 题 :Tetrahydro-imidazo quinoline compositions as CBP/P300 inhibitors
发明人：SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; DOWNING JENNIFER R; ERICSSON ANNA
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains, and methods of synthesis of these compounds.

专利号:JP-H07300461-A
优先权日:1986-01-22
标题 :Intermediate for synthesis of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H, 5H-benzo [i, j] quinolizine-2-carboxylic acid and process for producing the same

专利号:JP-H0759579-B2
优先权日:1986-01-22
标题:Synthesis of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H, 5H-benzo [i, j] quinolizine-2-carboxylic acid

专利号:JP-S62201888-A
优先权日:1986-01-22
标题:Synthesis of 6,7-dihydro-5,8-dimethyl-9-fluoro-1-oxo-1H,5H-benzo[i,j]quinolidine-2-carboxylic acid