CAS: 112193-75-6; 2,2'-(1,4,7,10-Tetraazacyclododecane-1,7-Diyl)Diacetic Acid

上下游产品

dibenzyl 4,10-bis(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate 1,4,7,10-tetraazacyclododecan 1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester (7-tert-butoxycarbonylmethyl-1,4,7,10-tetraaza-cyclododec-1-yl)-acetic acid tert-butyl ester

📜轮环藤宁置于盐酸,N,N-二异丙基乙胺体系中,用 乙腈 用作溶剂,化学反应 44.0H,反应生成1,4,7,10-四氮杂环十二烷-1,7-二乙酸
参考文献:A General Synthesis Of 1,7-Disubstituted 1,4,7,10-Tetraazacyclododecanes
标题:A General Synthesis Of 1,7-Disubstituted 1,4,7,10-Tetraazacyclododecanes
摘要:1,4,7,10-四氮杂环十二烷在酸性溶液中区域选择性地与多种氯甲酸酯反应,生成1,7-二保护衍生物,这些衍生物可以被烷基化并脱保护,从而得到1,7-二取代的1,4,7,10-四氮杂环十二烷.
Doi:10.1039/c39950000185

专利信息

专利号:US-5428155-A
优先权日:1984-10-18
标题 :Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups
发明人：SHERRY A DEAN; WESTRENEN JEROEN VAN
权利人:UNIV TEXAS
摘要:The pH controlled selectivity of the sulfomethylation reaction is used to prepare a series of di-, tri-, tetra- and hexaazacyclomacrocycles with specified patterns of pendent side-chain chelating groups. The prepared mono and diacetic acid derivatives, together with monomethylenephosphonate and monomethylenephosphinate derivatives of [12]aneN4, [12]aneN3 and [9]aneN3, make these types of ligands easily available by a synthetic pathway that avoids the use of protective groups. The invention thus comprises a variety of compounds, methods and uses characterized by relatively high synthetic yields of polyazamacrocyclic ligands exhibiting a wide and predictable choice of metal ion binding constants water and lipid solubilities by reason of their substituent pendent groups.

专利号:WO-9312097-A1
优先权日:1984-10-18
标 题 :Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups

专利号:EP-0618910-A1
优先权日:1984-10-18
标题 :Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups

专利号:US-5316757-A
优先权日:1984-10-18
标题 :Synthesis of polyazamacrocycles with more than one type of side-chain chelating groups