CAS: 924-42-5; N-(Hydroxymethyl)Acrylamide

• 英文名称N-(Hydroxymethyl)Acrylamide
• 中文名称N-羟甲基丙烯酰胺
• IUPAC名称N-(hydroxymethyl)acrylamide
• 其它别名N-甲基戊烯聚合物; N-Methylolacrylamide
• CAS编号924-42-5
• MFCD编号:MFCD00004597
• EINECS号:213-103-2
• FDA UNII编号:W8W68JL80Q
• 分子式:C4H7NO2
• 分子量:101.1
• 产品CID: 1962106
• 产品分类有机原料→分子砌块→脂肪链类化合物

• 相似结构搜索
• InChIKey: CNCOEDDPFOAUMB-UHFFFAOYSA-N
• InChI=1S/C4H7NO2/c1-2-4(7)5-3-6/h2,6H,1,3H2,(H,5,7)…
• 计算化学: 氢键受体数2.0氢键供体数2.0可旋转键数2.0

相似化合物

物理性质

• 熔点74-75°C
• 沸点355.1°C at 760 mmHg
• 闪点100°C
• 密度1.074
• PH:6.0-7.0 (H2O, 20°C)
• pKa:13.25±0.10(预测)
• PSA:49.33
• LogP:-0.7616
• 折射率1.459
• 蒸汽压0.0±1.5 mmHg at 25°C
• 溶解性Chloroform (Slightly), Methanol (Slightly)
• 敏感性常温常压下稳定 白色结晶性粉末。 易溶于水及亲水性溶剂，能溶于脂肪酸酯类，但几乎不溶于烃、卤代烃等疏水性溶剂 本品可燃，有毒，具刺激性。 当水溶液有酸存在时，加热会迅速聚合成不溶性树脂。由于分子结构中含有聚合性能的乙烯基和缩合性能的羟甲基，因此使线型聚合物最为有效。如果与丙烯酸酯类单体共聚合，羟甲基被引入，仅加热即可交联。低毒。
• 外观形态白色至类白色固体
• 储存条件储存在 <= 20°C.
• 产品应用作为共聚单体和交联剂,用于纤维加工,树脂加工,纸张和涂料工业.
• 性质描述白色结晶性粉末.熔点74-75°C,相对密度1.185(23/4°C).极易溶于水,几乎不溶于烃,卤代烃等疏水性溶剂.

MSDS等安全信息

• GHS象形图
• GHS符号GHS08 & GHS06;
  注释: Health hazard & Skull and crossbones
• 危险类别致癌性 类别1B
  Muta. 1B
  生殖毒性 类别2
  急性毒性 类别3(经口)
  特定目标器官毒性-重复接触 类别1
  皮肤致敏 类别1
  水生慢性毒性 类别4
  严重眼刺激 类别2
  皮肤致敏 类别1B
  致癌性 类别2
  皮肤腐蚀/刺激 类别2
  急性毒性 类别4(经口)
  急性毒性 类别4(经皮)
  致突变性 类别2
  致癌性 类别1A
  STOT SE 2
  特定目标器官毒性-重复接触 类别2
  Muta. 1A
• 警示词Danger(危险)
• 危险描述H350 |可能致癌.
  H340 |可能导致遗传缺陷.
  H361 |怀疑对生育能力或胎儿造成损害.
  H301 |吞咽会中毒.
  H372 |长期或反复接触损害器官.
  H317 |可能引起皮肤过敏反应.
  H413 |可能对水生生物造成长期有害影响.
  H319 |造成严重眼刺激.
  H351 |怀疑致癌.
  H315 |造成皮肤刺激.
  H302 |吞咽有害.
  H361f |怀疑会影响生育能力.
  H312 |皮肤接触有害.
  H341 |怀疑导致遗传缺陷.
  H371 |可能损害器官.
  H373 |长期或反复接触可能损害器官.
• 防范说明P260-P261-P264-P270-P272-P280-P302+P352-P330-P362+P364-P405-P501
• 危险等级6.1
• UN编号2811.0
• 危险品标志Xn,T
• 包装等级Ⅲ
• 安全声明26-45-36/37-53
• 危险类别码22-36/37/38-62-48/20/21/22-43-46-45
• WGK Germany3

欧盟法规

上下游产品

合成工艺路线路线简述

• 79-06-1 = 924-42-5
  反应条件:1.1 Reagents: 4-Methoxyphenol Catalysts: Triethylamine Solvents: Trichloroethylene; Ph 9.5,50 °C; 4 H,50 °C; 50 °C -> 15 °C
  标题:Preparation Of N-Hydroxymethylacrylamide With Trichloroethylene As Solvent
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Polyformaldehyde Catalysts: Sodium Methoxide Solvents: Acetone; Rt -> 45 °C; Ph 9 - 9.3,42 - 45 °C1.2 1 H,Ph 8.5,42 - 45 °C1.3 Reagents: Phthalic Acid; Ph 7 - 8; 21 - 23 °C
  标题:Method For Preparing N-Hydroxymethyl Acrylamide Crystal
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: 4-Methoxyphenol Catalysts: Tetramethylammonium Hydroxide Solvents: Water; 60 °C; 3 H,60 °C1.2 Reagents: Sulfuric Acid Solvents: Water; Ph 7.5 - 8.0
  标题:Method For Synthesizing And Crystallizing High-Purity N-Hydroxymethyl Acrylamide
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Solvents: Water; 1 - 1.5 H,Ph 7 - 9,35 - 40 °C
  标题:Copolymerization Of Acrylic Acid With Acrylamide Biuret Derivatives
  作者:Sirekanyan,I. N.; Kalantaryan,A. V.; Akopyan,G. V.; Eripyan,M. L.
  参考文献:Russian Journal Of Applied Chemistry 日期:2014 卷标:87(10) 页码:1570-1574]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Citric Acid,Hydroxyquinone Solvents: Water; Rt -> 90 °C; 3 H,90 °C
  标题:Study Of The Composition And Physicochemical Properties Of A Modifying Additive To A Lignosulfonate Drilling Reagent
  作者:Badikova,A. D.; Kulyashova,I. N.; Mustafin,A. G.; Safina,A. R.; R. Kireeva,D.; Et Al
  参考文献:Chemistry And Technology Of Fuels And Oils 日期:2023 卷标:59(2) 页码:249-254]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Ph 11.0,45 °C1.2 Reagents: Sulfuric Acid; Ph 3.61.3 Reagents: 4-Methoxyphenol Catalysts: Copper Sulfate; 45 °C -> 25 °C
  标题:Preparation Of Functional Monomer Etherified N-Methylolacrylamide
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: 4-Methoxyphenol Catalysts: Tetramethylammonium Hydroxide Solvents: Water; 60 °C; 3 H,60 °C1.2 Reagents: Sulfuric Acid Solvents: Water; Ph 7.5 - 8
  标题:Preparation Of N-Methylol Acrylamide
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Sodium Hydroxide; 3 H,Ph 8,45 °C
  标题:Method For Preparation Of Textile Finishing Agents
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Heated
  标题:Process For Preparation Of Chelating Group-Containing Monomer
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; 2 H,Ph 8 - 9,23 - 25 °C1.2 Reagents: Formic Acid; Ph 5 - 6
  标题:Effect Of Different Crosslinkers On Properties Of Melamine Formaldehyde-Furfuryl Alcohol Copolymer/montmorillonite Impregnated Softwood (Ficus Hispida)
  作者:Hazarika,Ankita; Maji,Tarun K.
  参考文献:Polymer Engineering & Science 日期:2013 卷标:53(7) 页码:1394-1404]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: 4-Methoxyphenol Catalysts: Triethylamine; Rt -> 45 °C; 2 H,Ph 9.5,45 °C1.2 Reagents: Sulfuric Acid Solvents: Water; Ph 7
  标题:Research On Synthesis Of N-Hydroxymethyl Acrylamide
  作者:Chen,Weihong; Li,Daguang; Li,Shuquan
  参考文献:Guangdong Huagong 日期:2005 卷标:32(10) 页码:40-41]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Catalysts: Sodium Hydroxide,Molybdenum Sodium Oxide Solvents: Water
  标题:Method For Producing N-Methylacrylamide
  参考文献:European Patent Organization]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Triphenyl Phosphate Catalysts: Sodium Hydroxide,Molybdenum Sodium Oxide Solvents: Water; 50 °C -> 65 °C; 3 H,65 - 70 °C
  标题:Green Preparation Of N-Methylolacrylamide Powder And Water Product
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Solvents: Diethyl Ether; 4 - 5 H,60 - 70 °C
  标题:High-Strength Double-Wall Corrugated Pipe And Preparation Method Thereof
  参考文献:China]
  
  9012-76-4 + 924-42-5 = 924-42-5
  反应条件:1.1 Reagents: 4-Methoxyphenol,Ammonium Chloride Solvents: Water; 10 Min,130 °C
  标题:Preparation Of Novel Chitosan Derivatives And Applications In Functional Finishing Of Textiles
  作者:Pan,Hong; Zhao,Tao; Xu,Lihui; Shen,Yong; Wang,Liming; Et Al
  参考文献:International Journal Of Biological Macromolecules 日期:2020 卷标:153 页码:971-976]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Sodium Hydroxide Catalysts: 4-Methoxyphenol Solvents: Water; Ph 8
  标题:New Design Of An Inkjet Printing Press Using Curable Water-Based Primers,Coatings And Inks
  参考文献:World Intellectual Property Organization]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Oxalic Acid,Hydrochloric Acid,Urea-Formaldehyde Resin,Sodium Chloride Sulfate Thiosulfate Solvents: Water; 0.25 - 0.3 Mpa; 0.7 - 1.6 H,15 - 30 °C
  标题:Composition For Polymer Sorbent And Method For Producing Sorbent From Composition
  参考文献:Russian Federation]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Ph 8.0 - 9.0,23 - 25 °C; 2 H,23 - 25 °C1.2 Reagents: Formic Acid; 2 H,Ph 5.0 - 6.0,23 - 25 °C
  标题:Studies On Effects Of Different Cross-Linkers On The Properties Of Starch-Based Wood Composites
  作者:Baishya,Prasanta; Maji,Tarun K.
  参考文献:Acs Sustainable Chemistry & Engineering 日期:2014 卷标:2(7) 页码:1760-1768]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Reagents: 4-Methoxyphenol Solvents: Water; 40 - 45 °C; 45 °C -> 25 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; 15 - 25 °C; 2 H,Ph 9.5 - 10,15 - 25 °C
  标题:Method For Preparation Of N-Hydroxymethylacrylamide
  参考文献:China]
  
  79-06-1 = 924-42-5
  反应条件:1.1 Catalysts: Ethanolamine; 4 - 6 H,Ph 9.4 - 9.6,50 °C1.2 Reagents: Sulfuric Acid Solvents: Water; Neutralized,< 15 °C
  标题:Method For Preparing N-Hydroxymethyl Acrylamide Using Number 200 Mineral Solvent
  参考文献:China

海关参考信息

• 2901210000-乙烯
  2901220000-丙烯
  2905110000-甲醇
  2912110000-甲醛
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• ➥ 象形图和危险代码
• ➥ 防范代码详解
• ➥ 危险代码说明
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