CAS: 76360-82-2; Ethyl 4-(Methylamino)-2-(Methylsulfanyl)-5-Pyrimidinecarboxylate

相似化合物

100973-67-9 17759-30-7 185040-32-8

上下游产品

CAS号5909-24-0 4-氯-2-甲硫基嘧啶-5-羧酸乙酯 | CAS号74-89-5 氨基甲烷 | CAS号593-51-1 一甲胺盐酸盐 | CAS号185039-37-6 N-[6-(2,6-二氯苯基)... | CAS号185039-48-9 6-(2,6-二氯苯基)-8-... | CAS号185039-46-7 6-(2,6-Dichloro... | CAS号17759-30-7 (4-甲基氨基-2-甲烷磺酰基... | CAS号185040-32-8 4-甲胺基-2-甲硫基-5-醛基嘧啶 | CAS号185039-29-6 6-(2,6-二氯苯基)-8-... | CAS号863028-98-2 4-(甲氨基)-2-(甲硫基)... | CAS号449811-92-1 6-(2,4-二氟苯氧基)-8... | CAS号449811-01-2 Pamapimod

4-氯-2-甲硫基嘧啶-5-羧酸乙酯置于甲胺体系中,用 乙醇,水 作为反应溶剂,化学反应生成 4-甲胺基-2-甲硫基-5-嘧啶甲酸乙酯
参考文献:6-Substituted Pyrido-Pyrimidines
标题:6-Substituted Pyrido-Pyrimidines
摘要:本发明提供了化合物i和ii的结构:其中r1,R3,W,Z,X1,X2,Ar1,R8和r9如本文所定义,并提供它们的制备方法和中间体以及它们的用途.

专利信息

专利号:US-7897762-B2
优先权日:2006-09-14
标 题:Kinase inhibitors useful for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:DECIPHERA PHARMACEUTICALS LLC
摘要:The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.

专利号:US-8188113-B2
优先权日:2006-09-14
标 题 :Dihydropyridopyrimidinyl, dihydronaphthyidinyl and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
发明人：FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C
权利人:FLYNN DANIEL L; PETILLO PETER A; KAUFMAN MICHAEL D; PATT WILLIAM C; DECIPHERA PHARMACEUTICALS INC
摘要:The present invention relates to novel dihydropyridopyrimidinyl, dihydronaphthyridinyl, and related compounds which are kinase inhibitors and modulator useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.