CAS: 74784-70-6; 5-(Trifluoromethyl)Pyridin-2-Amine

相似化合物

1211523-68-0 937602-15-8 945971-04-0

上下游产品

CAS号50488-42-1 2-溴-5-(三氟甲基)吡啶 | CAS号113495-47-9 2-(4-methoxyani... | CAS号52334-81-3 2-氯-5-三氟甲基吡啶 | CAS号22253-72-1 3-三氟甲基吡啶氮氧化物 | CAS号573676-20-7 (5-trifluoromet... | CAS号69045-78-9 2-氯-5-三氯甲基吡啶 | CAS号53359-69-6 3-硝基-5-三氟甲基吡啶-2-胺 | CAS号33252-64-1 2-羟基-3-硝基-5-(三氟甲基)吡啶 | CAS号79456-26-1 2-氨基-3-氯-5-三氟甲基吡啶 | CAS号79456-30-7 2-氨基-3-溴-5-三氟甲基吡啶 | CAS号860457-99-4 6-(三氟甲基)咪唑并[1,2... | CAS号211308-82-6 3-碘-5-(三氟甲基)-2-吡啶胺 | CAS号72587-15-6 2-氯-3-硝基-5-(三氟甲基)吡啶 | CAS号118000-42-3 2-(chloromethyl... | CAS号168123-87-3 7-Trifluorometh... | CAS号95651-19-7 [5-(三氟甲基)吡啶-2-基...

2-溴-5-(三氟甲基)吡啶置于copper(I) Oxide,Potassium Carbonate,Ammonium Hydroxide,N,N-二甲基乙二胺体系中,用 乙二醇 作为反应溶剂,化学反应 16.0H,以86%的收率获得产物2-氨基-5-三氟甲基吡啶
参考文献:Efficient Synthesis Of Aminopyridine Derivatives By Copper Catalyzed Amination Reactions
标题:Efficient Synthesis Of Aminopyridine Derivatives By Copper Catalyzed Amination Reactions
摘要:介绍了一种铜(I)催化的氨基化反应,该反应利用水合氨,并在温和条件下进行.这种方法用于高效合成不同的氨基吡啶衍生物,这些衍生物具有电子吸引基团和电子供给基团.
DOI:10.1039/b916569J

专利信息

专利号:US-6743811-B2
优先权日:1999-07-28
标 题:Oxazalidinone compounds and methods of preparation and use thereof
发明人：GORDEEV MIKHAIL F; LUEHR GARY W; PATEL DINESH V; GADWOOD ROBERT C
权利人:UPJOHN CO
摘要:Oxazolidinones and methods for their synthesis are provided. Further provided are methods of making biologically active oxazolidinones as well as pharmaceutically acceptable compositions comprising the oxazolidinones. Oxazolidinones as disclosed herein can be readily synthesized and used in a variety of applications including use as antimicrobial agents. In one embodiment, a variety of thioamidomethyloxazolidinones and methods for their synthesis and use are provided.

专利号:WO-2023091726-A1
优先权日:2021-11-18
标题:Inhibitors of cyclin‑dependent kinase 12 (cdk12)
发明人：BENOIT GUILLAUME; CARULLI JOHN; CHEN FEI; CHUAQUI CLAUDIO; CIBLAT STEPHANE; COOPER ELLIOT; DAGENAIS ROBIN; HU SHANHU; KABRO ANZHELIKA; LAPLACA DEREK; MARINEAU JASON; MOEBIUS DAVID; MOON DIANE; SOLODININ ANDREI; WHITMORE KENNETH
权利人:SYROS PHARMACEUTICALS INC
摘要:The present invention provides chemical compounds that inhibit one or more families of kinases (e.g., serine/threonine kinases, including one or more of the families of CDK proteins, and in particular, CDK12). More specifically, the present invention provides CDK12 inhibitors, of formula (I), pharmaceutically acceptable salts and isotopically labeled derivatives thereof, pharmaceutical compositions containing the compounds/inhibitors, and methods of their synthesis and use in treating proliferative diseases (e.g., a bladder cancer, a breast cancer, Ewing's sarcoma, a gastric cancer, a gastrointestinal cancer, a hematologic cancer, a lung cancer (e.g., small cell lung cancer (SCLC)), an ovarian cancer (e.g., a high grade serous ovarian cancer), a pancreatic cancer (e.g., pancreatic ductal adenocarcinoma (PDAC)), a brain cancer (e.g., glioblastoma), or a prostate cancer), alone or in combination with a second therapeutic agent. The proliferative disease can be a cancer, benign neoplasm, or pathologic angiogenesis, and any of the therapeutic methods or uses described herein can include a step of diagnosing the patient's disease. In other embodiments of the invention, the compositions described herein (e.g., the compounds, pharmaceutical compositions, and kits containing them) are used for the treatment of myotonic dystrophy (type 1 or type 2).

专利号:WO-9948868-A9
优先权日:1998-03-26
标 题 :Heterocyclic classes of compounds for the modulating tyrosine protein kinase
发明人：FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
权利人:SUGEN INC; UNIV NEW YORK; MAX PLANCK INST FUR BIOCHEMIE; FONG ANNIE; HANNAH ALISON; HARRIS G DAVIS; HIRTH PETER; HUBBARD STEVEN R; LANGECKER PETER; LIANG CONGXIN; MCMAHON GERALD; MOHAMMADI MOOSA; SCHLESSINGER JOSEPH; SHAWVER LAURA K; SUN LI; TANG PENG C; ULLRICH AXEL
摘要:The invention relates to certain indolinone-based and pyrazolylamide-based compounds, their method of synthesis, and combinatorial libraries consisting of the compounds. The invention also relates to methods of modulating the function of protein kinases using these compounds and methods of treating diseases by modulating the function of protein kinases and related signal transduction pathways.

专利号:US-4349681-A
优先权日:1979-12-24
标题:2-Amino-3-chloro-5-trifluoromethylpyridine
发明人：YOKOMICHI ISAO; HAGA TAKAHIRO; NAGATANI KUNIAKI; NAKAJIMA TOSHIO
权利人:ISHIHARA MINING & CHEMICAL CO
摘要:A novel compound, 2-amino-trifluoromethyl-halogenopyridine, is provided, which is prepared by amination of a 2-halogeno-trifluoromethyl-halogenopyridine or by halogenation of 2-amino-trifluoromethylpyridine. This compound is useful as an intermediate for synthesis of agricultural chemicals and medicines.

专利号:US-3963734-A
优先权日:1971-09-17
标 题:Lower alkylsulfonyl 2-amino, 3-nitro pyridines
发明人：DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.

专利号:US-4087432-A
优先权日:1974-05-23
标 题 :1H-imidazo(4,5-b)pyridine compounds
发明人：O DOHERTY GEORGE O P; FUHR KENNETH H
权利人:LILLY CO ELI
摘要:Substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo-(4,5-b)pyridine compounds useful as herbicides; and intermediates useful in the synthesis of these compounds. In addition to exhibiting herbicidal activity, the substituted 1-hydroxy-2-(1,1-difluoroalkyl)-1H-imidazo(4,5-b)pyridine compounds are of low mammalian toxicity.