邻氯苯乙酸置于n,N-二异丙基乙胺,Methanaminium,N-[(Dimethylamino)(3H-1,2,3-Triazolo[4,5-B]Pyridin-3-Yloxy)Methylene]-N-Methyl-,Hexafluorophosphate(1-)体系中,用 四氢呋喃,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 4.0H,反应生成 2-氯苯基乙酮 参考文献: Inhibiting Cyclic Amp-Responsive Element-Binding Protein (Creb)[fr] Inhibition De La Protéine De Liaison à Un élément Sensible à L'Amp Cyclique (Creb) 标题: Inhibiting Cyclic Amp-Responsive Element-Binding Protein (Creb)[fr] Inhibition De La Protéine De Liaison à Un élément Sensible à L'Amp Cyclique (Creb) 摘要:本公开涉及抑制cbp/p300家族溴结构域的抑制剂.这些化合物可用于治疗与抑制cbp/p300家族溴结构域相关的疾病或疾病.例如,该公开涉及用于抑制cbp/p300家族溴结构域的化合物和组合物,治疗与抑制cbp/p300家族溴结构域相关的疾病或疾病的方法(例如,某些形式的癌症),以及这些化合物的合成方法.
专利号:US-12351577-B2 优先权日:2019-03-15 标题 :Inhibiting cyclic AMP-responsive element-binding protein (CREB) 发明人:SCHILLER SHAWN E R; HERBERTZ TORSTEN; LI HONGBIN; GRAVES BRADFORD; MISCHKE STEVEN; WEST ANGELA V; ERICSSON ANNA; DOWNING JENNIFER R 权利人:FORMA THERAPEUTICS INC 摘要:The present disclosure is directed to inhibitors of the CBP/p300 family of bromodomains. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of the CBP/p300 family of bromodomains. For instance, the disclosure is concerned with compounds and compositions for inhibition of the CBP/p300 family of bromodomains, methods of treating diseases or disorders associated with the inhibition of CBP/p300 family of bromodomains (e.g., certain forms of cancer), and methods of synthesis of these compounds.
专利号:CN-115433958-B 优先权日:2021-06-03 标 题 :Electrochemical synthesis of 2-aminothiazole compounds
专利号:US-8178559-B2 优先权日:2004-12-30 标 题:Organic compounds 发明人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI 权利人:BREITENSTEIN WERNER; EHARA TAKERU; EHRHARDT CLAUS; GROSCHE PHILIPP; HITOMI YUKO; IWAKI YUKI; KANAZAWA TAKANORI; KONISHI KAZUHIDE; MAIBAUM JUERGEN KLAUS; MASUYA KEIICHI; IWASAKI ATSUKO; OSTERMANN NILS; SUZUKI MASAKI; TOYAO ATSUSHI; YOKOKAWA FUMIAKI; NOVARTIS AG 摘要:3,4-substituted piperidine compounds, these compounds for use in the diagnostic and therapeutic treatment of a warm-blooded animal, especially for the treatment of a disease (=disorder) that depends on activity of renin; the use of a compound of that class for the preparation of a pharmaceutical formulation for the treatment of a disease that depends on activity of renin; the use of a compound of that class in the treatment of a disease that depends on activity of renin; pharmaceutical formulations comprising a 3,4-substituted piperidine compound, and/or a method of treatment comprising administering a 3,4substituted piperidine compound, a method for the manufacture of a 3,4-substituted piperidine compound, and novel intermediates and partial steps for their synthesis are disclosed. The 3,4-disubstituted piperidine compounds have the formula (I), wherein the symbols have the meanings defined in the specification.
专利号:CN-107118103-A 优先权日:2017-06-29 标 题:A kind of insecticide indoxacarb intermediate and its synthesis technique
专利号:CN-108383703-A 优先权日:2018-03-30 标 题:A kind of 3 '-chlorophenylpropanol synthesis technique
参考标题:Development Of General Methods For The Synthesis Of New Substituted Allyl Bromides As Promising Alkenylating Agents 作者:A. I. Moskalenko,V. I. Boev |发布日期:2014.7 摘要:A General Procedure Has Been Developed For The Synthesis Of Hitherto Unknown Substituted Allyl Bromides. The Procedure Includes Preparation Of The Corresponding α,β-Unsaturated Carboxylic Acid Esters From Accessible Ketones According To The Horner-Emmons Reaction, Reduction Of These Esters With Diisobutylaluminum Hydride To Allylic Alcohols, And Substitution Of The Hydroxy Group By Bromine By The Action
合成参考文献
参考文献:10.1055/s-0040-1707887 摘要:Richardson J, Mutton SP, Martin FM, Walton L, Ledgard AJ. An Efficient Palladium-Catalyzed α-Arylation of Acetone Below its Boiling Point. Synlett. 2020 Jul 09;31(15):1532–6. doi: 10.1055/s-0040-1707887.