CAS: 62965-35-9; Boc-Tle-Oh

相似化合物

124655-17-0 169870-82-0 132684-60-7

上下游产品

CAS号20859-02-3 L-叔亮氨酸 | CAS号24424-99-5 二碳酸二叔丁酯 | CAS号58482-93-2 N-T-丁基甘氨酸 钠盐 | CAS号335628-21-2 (4S,5R)-3-tert-... | CAS号335627-81-1 2-Oxazolidinone... | CAS号58632-95-4 2-(叔-丁氧基碳酰胺)-2-苯乙腈 | CAS号1070-19-5 Carbonazidic ac... | CAS号1203546-60-4 (S)-ethyl 3,3-d... | CAS号69557-34-2 L-叔亮氨酸乙酯 | CAS号89226-12-0 L-叔亮氨酸甲基酰胺 | CAS号20859-02-3 L-叔亮氨酸 | CAS号630420-16-5 阿那匹韦 | CAS号340161-31-1 (S)-2-AMINO-N,N... | CAS号178933-95-4 l-valinamide, l... | CAS号153645-26-2 N-B°C-L-叔亮氨醇 | CAS号162537-11-3 N-甲氧羰基-L-叔亮氨酸 | CAS号230961-21-4 (3R)-3-[[(2S)-1... | CAS号230961-86-1 2-Methyl-2-prop... | CAS号394735-27-4 伯克匹韦

(S)-()-N-Boc-叔亮氨醇置于sodium Hypochlorite,2,2,6,6-四甲基哌啶氧化物,醋酸异丙酯,碳酸氢钠,Sodium Bromide体系中,用73%的收率获得产物n-Boc-L-叔亮氨酸
参考文献:一种n-烷氧或苄氧羰基手性氨酸的制备方法
标题:一种n-烷氧或苄氧羰基手性氨酸的制备方法
摘要:本发明提供了一种n‑烷氧或苄氧羰基氨酸的制备方法,具体地,提供了n‑烷氧或苄氧羰基手性氨酸的制备方法,更具体地,提供了一种n‑烷氧或苄氧羰基‑l‑氨酸或n‑烷氧或苄氧羰基‑d‑氨酸的制备方法.该方法无需使用拆分剂进行化学拆分,能够制备得到光学纯度高的n‑烷氧或苄氧羰基手性氨酸.n‑烷氧或苄氧羰基手性氨酸是非常重要的药物中间体.本发明提供的n‑烷氧或苄氧羰基‑l‑氨酸的制备方法,反应式如下:R1为烷基,优选地为叔丁基;r2为叠氮基或酰亚胺基,N为0或1,M为1.

专利信息

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2012095211-A1
优先权日:2010-09-22
标 题 :Substituted proline inhibitors of hepatitis c virus replication
发明人：BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D
权利人:BUCKMAN BRAD; NICHOLAS JOHN B; SEREBRYANY VLADIMIR; SEIWERT SCOTT D; INTERMUNE INC
摘要:The embodiments provide compounds of the general Formulae I, Ia, II, IIa, III, IIIa, IIIb, IV, IVa, IVb, V, Va, Vb, VI, VIa, VIb, and VIc, as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition. The embodiments also provide methods for the synthesis of subject compounds and intermediates in the synthetic methods.

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-9967219-A1
优先权日:1998-06-22
标 题:Compounds for inhibiting beta-amyloid peptide release and/or its synthesis
发明人：AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; PORTER WARREN J; THOMPSON RICHARD C; WILKIE STEPHEN C; STACK DOUGLAS R; SHI QING
摘要:Compounds of formula (I), wherein W is a cyclic group of the type (2); (3); Y is represented by the formula (II); these compounds inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:WO-9966934-A1
优先权日:1998-06-22
标 题 :CYCLIC AMINO ACID COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING β-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS
发明人：AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
权利人:ELAN PHARM INC; LILLY CO ELI; AUDIA JAMES E; DRESSMAN BRUCE A; SHI QING
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions comprising a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.