专利号:US-2024287126-A1 优先权日:2021-05-14 标 题:Novel synthesis of cholesterol 发明人:SCHINZER DIETER; SPIESS OLIVER; MUNT MAXIM; INDOLESE ADRIANO; ROUX LIONEL 权利人:CORDENPHARMA INT GMBH; UNIV OTTO VON GUERICKE MAGDEBURG; CORDENPHARMA INT 摘要:The invention relates to a synthesis of cholesterol; a ring opening step of the compound of formula (I) and subsequent activation and reduction step yielding cholesterol. The inventions relates also to intermediates achieved during said synthesis.
专利号:US-4284582-A 优先权日:1978-04-28 标 题 :Process for the preparation of cyclopropane derivatives, intermediates in the synthesis of pyrethroid insecticides 发明人:KAYE ALBERT E; TUCKER ALAN C 权利人:ICI LTD 摘要:Compounds of formula: wherein both groups X are chlorine, bromine or trifluoromethyl, or one X is chlorine or bromine and the other is trifluoromethyl, and Y is -CN or -COOR in which R is an alkyl group, are obtained by (A) reacting a compound of the formula: wherein X1 is chlorine or bromine, with a compound of the formula: X2C=CH-CH=C(CH3)2 in the presence of metallic copper or at least one copper salt and a base, or (B) reacting a compound of the formula: Y-CH2-CN with a compound of the formula: X2C=CH-CH=C(CH3)2 and chlorine or bromine, in the presence of at least one reducible copper salt and a base, or (C) reacting a compound of formula: X-CH2-CN with a compound of the formula: wherein X1 is chlorine or bromine, in the presence of at least one copper salt. The compounds are intermediates in the synthesis of pyrethroid insecticides.
专利号:US-12263464-B2 优先权日:2018-03-14 标题 :Method for in-situ synthesis of metal organic frameworks (MOFs), covalent organic frameworks (COFs) and zeolite imidazolate frameworks (ZIFs), and applications thereof 发明人:PAHWA DEEPAK; PAHWA VARUN; CHOUDHARY ANIL KUMAR; SONIA; JHA VIVEK KUMAR; CHAUHAN ANJALI; YADAV ANNU 权利人:DESICCANT ROTORS INTERNATIONAL PRIVATE LTD 摘要:The present invention relates to a method for the in situ synthesis of of MOFs (metal organic frameworks), COFs (covalent organic frameworks), and ZIFs (Zeolitic imidazolate framework), onto and within different types of porous substrates, and their applications. The present invention provides a unique and easy to utilize method by which a number of MOFs, COFs and ZIFs can be synthesized directly onto and within a porous substrate with high performance efficiency ensuring higher grammage in formation of adsorbent product onto and within the substrate.
专利号:US-6469133-B2 优先权日:1999-12-13 标题 :Process for the preparation of polymers of dimeric cyclic esters 发明人:BAKER GREGORY L; SMITH III MILTON R 权利人:UNIV MICHIGAN STATE 摘要:The present invention provides a process for the direct synthesis of high melting polymers made from dimeric cyclic esters. In particular, the present invention provides a process for synthesis of polylactic acid (PLA) from racemic materials such as racemic lactide and polymandelide from mandelide. The process further provides racemic metal organic ligand catalysts such as racemic salbinap that catalyzes the polymerization of racemic dimeric cyclic ester monomers to a polylactide stereocomplex. Polymandelide and mixed dimeric cyclic esters are also prepared in the presence of low amounts of water.
专利号:US-2024149253-A1 优先权日:2021-02-26 标 题 :Large scale synthesis of oxidative dehydrogenation catalyst 发明人:GAO XIAOLIANG; SIMANZHENKOV VASILY; SULLIVAN DAVID; DE WIT PERRY; DRAG HANNA; KIM YOONHEE 权利人:NOVA CHEM INT SA 摘要:Catalysts and Methods for large-scale production of the catalysts are provided. An exemplary catalyst composition includes molybdenum, vanadium, tellurium, niobium, oxygen. In the catalyst composition, the molar ratio of molybdenum to vanadium is from 1:0.05 to 1:0.60, the molar ratio of molybdenum to tellurium is from 1:0.01 to 1:0.30, and the molar ratio of molybdenum to niobium is from 1:0.01 to 1:0.40. Oxygen is present at least in an amount to satisfy the valency of any present metal oxides, and composition includes less than 1.0 wt. % of sulfur.
专利号:US-6133473-A 优先权日:1998-06-25 标 题 :Synthesis of carbamate compounds 发明人:BERRIER JOHN VINCENT 权利人:ROHM & HAAS 摘要:Disclosed is a method for the preparation of carbamate compounds substantially free of by-products; the carbamate compounds being prepared by reacting an isocyanate with a hydroxylated compound in the presence of certain catalysts that increase the rate of carbamylation while decreasing the rate of by-product formation.
1. Xie, M., Gu, S., Liu, Y., et al. 2-Hydroxyisobutyric acid targeted binding to MT-ND3 boosts mitochondrial respiratory chain homeostasis in hippocampus to rescue diabetic cognitive impairment. Redox Biol. 79, 103446 (2025). 2. Schifano, E., Conta, G., Preziosi, A., et al. 2-hydroxyisobutyric acid (2-HIBA) modulates ageing and fat deposition in Caenorhabditis elegans. Front. Mol. Biosci. 9, 986022 (2022).
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