CAS: 520-28-5; 5-Hydroxy-7-Methoxy-2-Phenyl-4H-Chromen-4-One
该化合物是天然形成的食草类化合物,主要存在于各种植物物种中,其特征是黄色晶状外观,以潜在的抗氧化剂和抗炎特性著称;切除色素属于氟拉松类,其特征是特定化学结构,包括一个铬骨架;该化合物因其可能的治疗效应,包括抗癌和...
- 英文名称5-Hydroxy-7-Methoxy-2-Phenyl-4H-Chromen-4-One
- 中文名称杨芽黄素
- IUPAC名称5-hydroxy-7-methoxy-2-phenyl-4H-chromen-4-one
- 其它别名2-Phenyl-5-Hydroxy-7-Methoxy-4H-1-Benzopyran-4-One; 7-Methoxy-2-Phenyl-5-Hydroxy-4H-1-Benzopyran-4-One; Techto; Techtochrysine; Tectochrysin; Chrysin 7-Methyl Ether; Methyl Chrysin
- CAS编号520-28-5
- MFCD编号:MFCD00016945
- FDA UNII编号:9UBO28W2AK
- 分子式:C16H12O4分子量:268.27
- 产品CID: 1511058
- 产品分类天然产物 → 黄酮类化合物
物理性质
- 熔点166-168°C
- 沸点487.4±45.0 °C(预测)
- 闪点186.8 °C
- 密度1.329±0.06 g/cm3(预测)
- pKa:6.34±0.40(预测)
- PSA:59.67
- LogP:3.130 (est)
- 折射率1.641
- 蒸汽压4E-10 mmHg at 25 °C
- 溶解性DMSO: 16.67 mg/mL (62.14 Mm; Need Ultrasonic)
- 外观形态白色粉末
- 储存条件2-8°C
- 产品应用该化合物用于研究和分析应用.TETTOCHRYSEN(TECHTOCHLYSIN)是ALPINIA OXYPHILLA MIQUEL的主要裂变体之一.TECTOCHRYSAN抑制NF-NB的活动.
MSDS等安全信息
上下游产品
diazomethane 5,7-dihydroxy-2-phenyl-chromen-4-one dimethyl sulfate methyl iodide 5-acetoxy-7-methoxyflavone 5,8-dihydroxy-7-methoxyflavone pinostrobin acetic acid合成工艺路线路线简述
📜白杨素置于三溴化硼,Potassium Carbonate体系中,用 二氯甲烷,丙酮 作为反应溶剂,化学反应 2.0H,反应生成 杨芽黄素
参考文献:Synthesis And Evaluation Of Selenoflavones That Have Potential Neuroprotective Effects
标题:Synthesis And Evaluation Of Selenoflavones That Have Potential Neuroprotective Effects
摘要:We Synthesized Selenoflavones And Evaluated Their Physicochemical Properties And Antioxidant Effects. When Oxygen Was Substituted With Selenium,The Compounds Exhibited Improved Polarity And Lipophilicity,Implying That This Change Could Lead To Better Bbb Penetration. Selenoflavones Revealed More Potent Antioxidant Activity In Our In-Vitro Assay. This Suggests That Selenoflavones Would Be More Druggable Than Flavones And Have A Better Potential As A Neuroprotective Agent.
DOI:10.3987/com-14-13112
海关参考信息
- 2905110000-甲醇
2907221000-对苯二酚
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
1: Ghallab DS, Shawky E, Metwally AM, Celik I, Ibrahim RS, Mohyeldin MM. Integrated in silico - in vitro strategy for the discovery of potential xanthine oxidase inhibitors from Egyptian propolis and their synergistic effect with allopurinol and febuxostat. RSC Adv. 2022 Jan 21;12(5):2843-2872. doi: 10.1039/d1ra08011c.
2: Mahoney O, Melo C, Lockhart A, Cornejal N, Alsaidi S, Wu Q, Simon J, Juliani R, Zydowsky TM, Priano C, Koroch A, Fernández Romero JA. Antiviral activity of aframomum melegueta against severe acute respiratory syndrome coronaviruses type 1 and 2. S Afr J Bot. 2022 May;146:735-739. doi: 10.1016/j.sajb.2021.12.010. Epub 2021 Dec 18.
3: Ahmed QU, Sarian MN, Mat So'ad SZ, Latip J, Arief Ichwan SJ, Hussein NN, Taher M, Alhassan AM, Hamidon H, Fakurazi S. Methylation and Acetylation Enhanced the Antidiabetic Activity of Some Selected Flavonoids: In Vitro, Molecular Modelling and Structure Activity Relationship-Based Study. Biomolecules. 2018 Nov 15;8(4):149. doi: 10.3390/biom8040149.
合成参考文献
参考文献:10.1186/1475-2891-10-73
摘要:Bojić M, Debeljak Ž, Tomičić M, Medić-Šarić M, Tomić S. Evaluation of antiaggregatory activity of flavonoid aglycone series. Nutrition Journal. 2011 Jul 11;10(1):73. doi: 10.1186/1475-2891-10-73.
参考文献:10.1021/np50001a002
摘要:Edwards JM, Raffauf RF, Le Quesne PW. Antineoplastic activity and cytotoxicity of flavones, isoflavones, and flavanones. J Nat Prod. 1979 Jan;42(1):85–91. doi: 10.1021/np50001a002.
参考文献:10.4103/0971-4065.82131
摘要:Boutabet K, Kebsa W, Alyane M, Lahouel M. Polyphenolic fraction of Algerian propolis protects rat kidney against acute oxidative stress induced by doxorubicin. Indian J Nephrol. 2011 Apr;21(2):101–6.
📝 需求与反馈
尽可能描述清楚需求与问题信息
