CAS: 51-34-3; Scopolamine

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CAS号17659-49-3 消旋山莨菪碱 | CAS号30286-75-0 氧托溴铵 | CAS号498-45-3 东莨菪醇 | CAS号529-64-6 托品酸 | CAS号487-27-4 莨菪灵 | CAS号492-38-6 2-苯基丙烯酸 | CAS号17659-49-3 消旋山莨菪碱 | CAS号126371-43-5 (-)-Anisodamine | CAS号101-31-5 天仙子胺 | CAS号5441-68-9 3-bromo-2-pheny...

山莨菪碱置于alpha-酮戊二酸,Atropa Belladonna C-Terminally Hexahistidine-Tagged Hyoscyamine 6β-Hydroxylase,Iron(II) Sulfate,Sodium Ascorbate,Catalase体系中,化学反应 1.0H,反应生成 东莨菪碱
参考文献:Functional Characterization Of Recombinant Hyoscyamine 6β-Hydroxylase From Atropa Belladonna
标题:Functional Characterization Of Recombinant Hyoscyamine 6β-Hydroxylase From Atropa Belladonna
摘要:(-)-东莨菪碱是阿托品的旋光纯形式,而其衍生物天仙子胺是托品烷生物碱的一种,在药物中有着广泛应用.东莨菪碱6β-羟化酶(h6H,Ec 1.14.11.11),一种单体α-酮戊二酸依赖型双加氧酶,通过两步连续反应将(-)-东莨菪碱转化为其中间体6,7-环氧衍生物--天仙子胺.本研究中,我们对毒蕈(atropa Belladonna)来源的h6H(abh6H)进行了克隆,异源表达,纯化及功能表征.实验发现,Abh6H的催化效率较低,尤其是在第二次氧化反应中,这可能是毒蕈相比同属其他物种产生更少天仙子胺的原因之一.潜在的最终环氧化前体--6,7-脱氢东莨菪碱,通过体外o-18标记实验,证实其并非天仙子胺生物合成的必要中间体.此外,托品烷环中的氮原子在底物识别过程中扮演了关键角色.版权 © 2012 Elsevier Ltd. 保留所有权利.
DOI:10.1016/j.Bmc.2012.05.042

专利信息

专利号:US-5565606-A
优先权日:1986-10-21
标 题:Synthesis of peptide aminoalkylamides and peptide hydrazides by the solid-phase method
发明人：BREIPHOL GERHARD; KNOLLE JOCHEN
权利人:HOECHST AG
摘要:The invention relates to compounds of the formula I in which A denotes hydrogen or an amino protective group, B denotes one or more amino acids, X denotes alkylene or aralkylene, Y1, Y2, Y3 and Y4 are identical or different and denote hydrogen, methyl, methoxy or nitro, V denotes hydrogen or a carboxyl protective group, W denotes -[CH2]n- or -O-[CH2]n-, m denotes 0 or 1, n denotes 0 to 6, and p denotes 0 to 5, to a process for their preparation. The compounds of formula I are useful as linkage agents or anchor groups in the solid-phase synthesis of peptide aminoalkylamides and peptide hydrazides.

专利号:US-2024082118-A1
优先权日:2021-05-19
标 题:Topical compositions and methods of preparing the same
发明人：ABRAMOVICH SAGI; AVIDOR GAL; LANDA BENZION
权利人:LANDA LABS 2012 LTD
摘要:There is disclosed a composition comprising a water-insoluble thermoplastic compound capable of stimulating collagen synthesis (CSSC), the CSSC having a molecular weight of more than 0.6 kDa and being dispersed in a polar carrier as nano-elements having an average diameter of 200 nm or less and a viscosity of 107 mPa·s or less. The nano-elements of CSSC can be capable of stimulating the synthesis of skin proteins and/or enabling the delivery of active agents upon their application to a surface to be treated therewith. Methods for preparing the compositions and uses thereof are also provided.

专利号:US-2008311580-A1
优先权日:2004-03-09
标 题:Novel genes encoding proteins involved in proanthocyanidin synthesis
发明人：ABRAHAMS SHARON; ASHTON ANTHONY RICHARD; TANNER GREGORY JOHN; LARKIN PHILIP JOHN
权利人:COMMW SCIENT IND RES ORG
摘要:This inventions provides an isolated protein or polypeptide having activity in the synthesis of proanthocyanidin (PA) polymer from epicatechin or catechin in plants, and which is not naturally regulated by the TT2 or TT8 regulators, or a fragment comprising at least about 10 contiguous amino acids derived from said protein or polypeptide, particularly TDS1, TDS2, TDS3, TDS4, TDS5, or TDS6 protein, or fragment thereof. n Also provided are nucleic acid encoding such proteins or polypeptides; plant cells and plants containing and expressing such nucleic acids; antibodies that bind to such proteins or polypeptides; and related methods.

专利号:WO-2013087821-A1
优先权日:2011-12-15
标题:Overproduction of jasmonates in transgenic plants
发明人：CHAMPION ANTONY
权利人:INST RECH DEVELOPPEMENT IRD
摘要:La present invention relates to the use of a nucleic sequence allowing the synthesis of Gh ERF-IIa, Gh ERF-IIb or Gh ERF-IIc in a plant in order to induce, in the plant, an overproduction or accumulation of jasmonic acid and/or OPDA. The accumulation of jasmonic acid and/or OPDA confers, in particular, to the transformed plant an improved resistance to bioagressors. The nucleic sequences, transformation methods and transformed plants according to the invention may also been used for the production of pharmaceutically important secondary metabolites whose synthesis is induced by jasmonates.

专利号:US-7576211-B2
优先权日:2004-09-30
标题 :Synthesis of thienopyridinone compounds and related intermediates
发明人：DHANOA DALE S; BECKER OREN; NOIMAN SILVIA; CHEN DONGLI; MARANTZ YAEL; SHACHAM SHARON; HEIFETZ ALEXANDER; INBAL BOAZ; BAR-HAIM SHAY; MOHANTY PRADYUMNA; LOBERA MERCEDES; WU LAURENCE
权利人:EPIX DELAWARE INC
摘要:The invention relates to 5-HT receptor agonists and partial agonists. Novel thienopyridinone compounds represented by Formula I, and synthesis and uses thereof for treating diseases mediated directly or indirectly by 5-HT receptors, are disclosed. Such conditions include Alzheimer's disease, cognition disorders, irritable bowel syndrome, nausea, emesis, vomiting, prokinesia, gastroesophageal reflux disease, nonulcer dyspepsia, depression, anxiety, urinary incontinence, migraine, arrhythmia, atrial fibrillation, ischemic stroke, gastritis, gastric emptying disorders, feeding disorders, gastrointestinal disorders, constipation, erectile dysfunction, and respiratory depression. Methods of preparation and novel intermediates and pharmaceutical salts thereof are also included.

专利号:US-4873342-A
优先权日:1985-04-16
标题:Dipeptide derivative and synthesis and use thereof
发明人：TANAKA TAKAHARU; SAITOH MASAYUKI; HIGUCHI NAOKI; HASHIMOTO MASAKI
权利人:SUNTORY LTD
摘要:A novel depeptide derivative which exhibits inhibitory activity against prolyl endopeptidase and is effective for preventing and curing amnesia is disclosed. A process for chemical synthesis of such a derivative, as well as its use, is also disclosed.