CAS: 42142-52-9; 3-(Methylamino)-1-Phenylpropan-1-Ol

上下游产品

CAS号877-50-9 3-(METHYLAMINO)... | CAS号5409-62-1 3-(苄基(甲基)氨基)-1-... | CAS号21970-65-0 3-(苄基(甲基)氨基)-1-... | CAS号68408-65-1 2-甲基-5-苯基异噁唑啉 | CAS号18776-12-0 3-氯-1-苯基丙醇 | CAS号74-89-5 氨基甲烷 | CAS号2538-50-3 3-(甲基氨基)-1-苯基丙-... | CAS号62872-58-6 3-iodo-1-phenyl... | CAS号98-86-2 苯乙酮 | CAS号936-59-4 3-氯代苯丙酮 | CAS号56296-78-7 盐酸氟西汀 | CAS号100-52-7 苯甲醛 | CAS号98-88-4 苯甲酰氯 | CAS号98-86-2 苯乙酮 | CAS号768-03-6 苯基丙烯基酮 | CAS号28075-29-8 N-甲基-3,3-二苯基丙胺 | CAS号54910-89-3 氟西汀

3-(N-苄基-N-甲基氨基)苯丙酮盐酸盐置于5% Pdcl2 On Carbon 氢气体系中,用 水,乙酸乙酯 作为反应溶剂,55.0~57.0 °C,343.24 Kpa 条件下,反应 1.0H,反应生成 N-甲基-3-苯基-3-羟基丙胺
参考文献: Synthesis Of Atomoxetine Hydrochloride[fr] Synthese D'Hydrochlorure D'Atomoxetine
标题: Synthesis Of Atomoxetine Hydrochloride[fr] Synthese D'Hydrochlorure D'Atomoxetine
摘要:(+/-)-酒石酸阿托莫西汀ii型晶体和固体(+/-)-阿托莫西汀游离碱在制备盐酸阿托莫西汀时是有用的.

专利信息

专利号:US-8367868-B2
优先权日:2006-10-16
标题:Process for the synthesis of aryloxypropylamine and heteroaryloxypropylamine
发明人：BERTOLINI GIORGIO; VERZOLA BARBARA; VERGANI DOMENICO
权利人:ARCHIMICA SRL; BERTOLINI GIORGIO; VERZOLA BARBARA; VERGANI DOMENICO
摘要:The present invention relates to a process for the synthesis of aryloxypropylamine and heteroaryloxypropylamine of formula I: n nwhere: A is aryl or heteroaryl, where the aryl is preferably a phenyl, optionally substituted, selected from benzyl and tolyl and the heteroaryl is preferably thiophenyl; Y is an aryl, preferably phenyl, a substituted phenyl or a naphthyl, where the substituted phenyl is preferably selected from tolyl, trihalomethyltolyl and alkoxytolyl, starting from a suitable amino alcohol of formula II:

专利号:US-6846957-B2
优先权日:2002-11-22
标题 :Synthesis of 3-aminomethyl-1-propanol, a fluoxetine precursor
发明人：ZELENIN ALEXANDER
权利人:UNIV TEXAS
摘要:The present invention concerns a method of synthesizing fluoxetine hydrochloride. The method includes the synthesis of 3-methylamino-1-phenyl-1-propanol by reduction of 1-phenyl-3-methylamino-2-propen-1-one with sodium borohydride and acetic acid.

专利号:US-7507861-B2
优先权日:2004-06-28
标题:Process for the preparation of atomoxetine hydrochloride
发明人：CASTELLI EUGENIO; LO MONACO GIUSEPPE; MANTOVANI SILVIA; DAVERIO PAOLA; RIVA PAOLO; VAILATI ALESSANDRA; BIANCHI STEFANO
权利人:TEVA PHARM FINE CHEMICALS SRL
摘要:The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water.

专利号:US-7439399-B2
优先权日:2004-06-28
标题:Processes for the preparation of atomoxetine hydrochloride
发明人：ARONHIME JUDITH; BIANCHI STEFANO; CASTELLI EUGENIO; DAVERIO PAOLA; MANTOVANI SILVIA; KOVACSNE-MEZEI ADRIENNE
权利人:TEVA PHARM FINE CHEMICALS SRL
摘要:The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HCl by adding HCl to a mixture of (R)-(−)-tomoxetine (S)-(+)-mandelate with an organic solvent, with or without a base and water. In preferred embodiments, the atomoxetine hydrochloride produced is Form A.

专利号:US-6838581-B2
优先权日:2002-12-04
标题:Process for the preparation of enantiomerically pure 3-phenyl-3-hydroxypropylamine
发明人：KUMAR PRADEEP; PANDEY RAJESH KUMAR
权利人:COUNCIL SCIENT IND RES
摘要:The present invention relates to an improved process for the synthesis of enantiomerically pure 3-phenyl-3-hydroxypropylamine of formula I; more particularly the present invention relates to the said process using styrene; n n nthe synthetic strategy features a Sharpless asymmetric dihydroxylation (SAD) route to the target compound, using styrene, a readily accessible starting material gives the optically pure dihydroxy compound (ee >97%; the selective monotosylation of primary alcohol, nucleophilic displacement by cyano and subsequent reduction to amino group furnishes the desired 3-phenyl-3-hydroxypropylamine in enatiomerically pure form, a key intermediate in the synthesis of variety of oxetine related anti-depressant drugs.

专利号:EP-1673335-A2
优先权日:2004-06-28
标 题 :Process for the preparation of atomoxetine hydrochloride
发明人：CASTELLI EUGENIO; LO MONACO GIUSEPPE; MANTOVANI SILVIA; DAVERIO PAOLA; RIVA PAOLA; BIANCHI STEFANO
权利人:TEVA PHARM FINE CHEMICALS SRL
摘要:The present invention provides improved processes for the preparation of atomoxetine hydrochloride under reaction conditions that improve reaction yields and facilitate commercial synthesis. In particular, the invention is directed to the synthesis of atomoxetine HC1 by adding HCl to a mixture of (R)-(-)-tomoxetine (S)-(+)­mandelate with an organic solvent, with or without a base and water.