CAS: 4024-14-0; 1-Methyl-3,4-Dihydronaphthalen-2(1H)-One

上下游产品

4-methyl-1,2-dihydronaphthalene 2-methoxy-1-methylnaphthalene 1,2,3,4-tetrahydronaphthalen-2-one methyl iodide (1-Methyl-3,4-dihydro-naphthalen-2-yl)-((S)-1-phenyl-ethyl)-amine 1-Benzyl-1-methyl-1,4-dihydronaphthalen-2-one

📜1,2-Epoxy-1-Methyl-1,2,3,4-Tetrahydro-Naphthalene置于indium(Iii) Chloride体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.75H,以87%的收率获得产物1-甲基-2-四氢萘酮
参考文献:Indium(Iii) Chloride-Promoted Rearrangement Of Epoxides: A Selective Synthesis Of Substituted Benzylic Aldehydes And Ketones
标题:Indium(Iii) Chloride-Promoted Rearrangement Of Epoxides: A Selective Synthesis Of Substituted Benzylic Aldehydes And Ketones
摘要:A Simple And Efficient Procedure For The Rearrangement Of Substituted Epoxides Catalyzed By Incl3 Has Been Developed. Aryl-Substituted Epoxides Isomerize With Complete Regioselectivity To Form A Single Carbonyl Compound Via Cleavage Of The Benzylic C-O Bond. The Reactions Are Simple,Fast,And High Yielding. This Procedure Is Very Mild Compared To Those Catalyzed With Bf3 And Other Lewis Acids And Compatible With Several Acid-Sensitive Functionalities. This Protocol Provides A Highly Selective Synthesis Of Substituted Benzylic Aldehydes And Ketones. However,Rearrangement Of Alkyl-Substituted Epoxides Is Not Very Selective.
DOI:10.1021/jo980793W

专利信息

专利号:RU-2014330-C1
优先权日:1988-05-23
标题:Method of synthesis of 1,2,3,4-tetrahydronaphthalene derivatives or their pharmaceutically acceptable acid-additive salt

专利号:RU-2126386-C1
优先权日:1991-08-21
标 题:Benzo-[f]-quinolinones, method of inhibition, method of synthesis of benzo-[f]-quinolinones, method of racemates splitting and di-p-toluoyl-(d)- or (l)-tartaric acid salt

专利号:CN-113527130-B
优先权日:2021-05-22
标 题:Synthesis method of alpha-amide, alpha-aryl quaternary carboketone compound