CAS: 3470-98-2; 1-Butylpyrrolidin-2-One

相似化合物

2687-91-4 2687-94-7 2687-96-9

上下游产品

CAS号616-45-5 2-吡咯烷酮 | CAS号123-72-8 正丁醛 | CAS号4538-09-4 N-vinylmethyl(1... | CAS号201230-82-2 carbon monoxide | CAS号109-65-9 正溴丁烷 | CAS号109-69-3 1-氯丁烷 | CAS号1912-32-9 甲烷磺酸丁酯 | CAS号542-69-8 碘代正丁烷 | CAS号96-48-0 γ-丁内酯 | CAS号4543-95-7 4-(丁氨基)-1-丁醇

1-(丁-1-烯基)吡咯烷-2-酮置于氧气,一水合肼,7-(Trifluoromethyl)-1,10-Ethyleneisoalloxazinium Chloride体系中,用 水 用作溶剂,100.0 °C,101.33 Kpa 条件下,反应 18.0H,以93%的收率获得1-丁基-2-吡咯烷酮
参考文献:水中酰胺的有机催化二酰亚胺还原.
标题:水中酰胺的有机催化二酰亚胺还原.
摘要:桥接的黄酮有机催化剂在二酰亚胺介导的水性条件下的酰胺还原中显示出功效.这代表了富电子烯烃的第一次二酰亚胺还原,并为使用烷基化剂进行n-烷基化提供了一种清洁的替代方法.
Doi:10.1039/c0Cc02272A

专利信息

专利号:US-2023242581-A1
优先权日:2020-06-17
标题:Synthesis of a guanylate cyclase agonist by fragments based approach
发明人：SAMBASIVAM GANESH; KASTURCHAND GODHA ATUL; VENKATA BHAGYARAJ ARETI; ANNADURAI SATHYA; VEERANJANEYULU AVULA; VASANTRAO GADAKH AMOL; S JADHAV DIPAK
权利人:ANTHEM BIOSCIENCES PRIVATE LTD
摘要:The present invention provides a process for the synthesis of Plecanatide, a guanylate cyclase agonist. The process involves convergent synthesis with compounds, i.e., fragment of peptides followed by cyclization. The method provides high yield of Plecanatide with less impurities.

专利号:US-7723539-B2
优先权日:2004-06-16
标题:Catalysts based on metal complexes for the synthesis of optically active chrysanthemic acid
发明人：CARLONI SILVIA; BORZATTA VALERIO; MORONI LENI; TANZI GIADA; SARTORI GIOVANNI; MAGGI RAIMONDO
权利人:ENDURA SPA
摘要:Catalysts are described based on metal complexes derived from optically active s compounds, chosen from the classes consisting of bisoxazolines and salicylaldimines supported on an organic or inorganic matrix and employed in particular for the synthesis of optically active chrysanthemic acid.

专利号:WO-2024163644-A1
优先权日:2023-02-01
标题:Belt reactor manufacturing process for oligomer synthesis
发明人：KELLER KARSTEN; HILLEBRAND ROMAN
权利人:ARROWHEAD PHARMACEUTICALS INC
摘要:A method and apparatus for synthesis of oligomers such as oligonucleotides and peptides are disclosed. The method employs a device including at least one deprotection station to carry out a step of deprotection, at least one coupling station to carry out a step of coupling, optionally, one or more oxidation and/or thiolation stations to carry out a step of oxidation or thiolation, optionally, one or more capping stations to carry out a step of capping, and, optionally, one or more washing stations to carry out a step of washing. A plurality of solid phase material for oligomer synthesis is moved to the stations via a conveyor device, wherein a fluid delivery device acts upon said solid phase material to produce an oligomer.

专利号:WO-2025149479-A1
优先权日:2024-01-12
标题:Synthesis of modified nucleoside triphosphates
发明人：KUCHELMEISTER HANNES; PFAFFENEDER TONI; MEX MARTIN; VETH SIMON; MENKE JAN-MICHAEL
权利人:ROCHE DIAGNOSTICS GMBH
摘要:The invention relates to a new diastereoselective synthesis method for highly modified nucleoside triphosphates with two conjugable groups. The method works in liquid phase with conventional laboratory equipment as used in any chemical laboratory or production. For this, a new chiral P(V) phosphorylation reagent has been designed that allows highly efficient diastereoselective synthesis under mild conditions. Overall, a highly efficient, diastereoselective, high quality, cost-effective synthetic method of modified nucleoside triphosphates has been developed.

专利号:WO-2025073833-A1
优先权日:2023-10-04
标 题:Optimized process for the preparation of iopamidol
发明人：BUONSANTI FEDERICA; MAZZON ROBERTA; FRETTA ROBERTA
权利人:BRACCO IMAGING SPA
摘要:The present invention relates to the field of organic chemistry, in particular to the synthesis of iodinated contrast agents. More in particular, the invention relates to a sustainable process for the synthesis of iopamidol which allows to improve the purity profile of the product and avoids the use of potentially hazardous reagents and solvents.

专利号:US-2023391818-A1
优先权日:2020-11-05
标 题:Peptide synthesis method for suppressing defect caused by diketopiperazine formation
发明人：NOMURA KENICHI; KAGE MIRAI; TAMIYA MINORU; KANAZAWA JUNICHIRO
权利人:CHUGAI PHARMACEUTICAL CO LTD
摘要:Solid-phase synthesis of a peptide has a problem that a desired elongation reaction is prevented from proceeding by diketopiperazine and a 6-membered diamine skeleton compound formed when a protective group at the N-terminal is removed. The present inventors have found that when in production of a peptide by a solid-phase method, a peptide in which an amino group at the N-terminal is protected with a protective group having an Fmoc skeleton is treated in a specific solvent with a base having a pKa of 23 or more in acetonitrile as a conjugate acid, and a peptide chain is then elongated, it is possible to solve the problem described above.