CAS: 3222-05-7; Methyl 2,2,2-Tribromoacetate

该化合物是一种有机化合物,其特点是分子式C4H5Br3O2.它是一种无色的黄色液体,具有甜美果味的黄色味,其溴含量较高,有助于其反应性,并有可能用于有机合成,特别是溴化化合物的生产. 甲基三溴乙酸盐在有机溶剂中可溶解,但由于其疏水性,溶解于水中,溶解性有限.它经常被用作各种制药和农用化学品合成的中间体.溴原子的存在使得它成为与环境化学有关的研究的主体,因为溴化化合物可产生重大的生态影响.在处理该物质时,必须采取安全防范措施,因为它可能通过吸入或皮肤接触对健康造成危害.建议在远离光的冷干地方适当储存,以保持其稳定性并防止降解.

结构式图片

物理性质

MSDS等安全信息

欧盟法规

ECHA物质C&L通报

上下游产品

methanol tribromoacetic acid dimethyl sulfate tribromoacetyl chloridemethyl bromodifluoroacetate trans-2,3-dibromobutenedioic acid dimethyl ester -glyoxylsaeure-methylester2-1-Brom-cyclohexyl-glyoxylsaeure-methylester methyl 2,2-dibromo-3-hydroxy-3-phenylpropanoate

合成工艺路线路线简述

    📜甲醇,三溴乙酰氯 以95%的收率获得产物三溴乙酸甲酯
    参考文献:合成微管稳定海绵生物碱ceratamine A的抗有丝分裂类似物.
    标题:合成微管稳定海绵生物碱ceratamine A的抗有丝分裂类似物.
    摘要:从三溴咪唑开始合成了微管稳定海绵生物碱ceratamine A(1)的抗有丝分裂类似物.合成中的关键步骤是通过乙烯基溴化物和n-甲基酰胺之间的分子内布赫瓦尔德偶联形成氮杂环.这代表了完全不饱和咪唑并[4,5,D]氮杂的首次合成.从合成的ceratamine类似物获得的NMR数据为归属于天然产物的结构提供了支持.
    DOI:10.1021/ol7030284

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    专利信息


    专利号:US-7084281-B2
    优先权日:2003-01-22
    标题:Synthesis of dihalohydrins and tri- and tetra-substituted olefins
    发明人：FALCK JOHN R; BARMA DEB K; KUNDU ABHIJIT
    权利人:UNIV TEXAS
    摘要:A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction of aldehyde or ketone with a trihalogenated compound such as trichloroacetate in the presence of CrCl 2 in a solvent. By varying the amount of CrCl 2 used, the stable dihalohydrin intermediate may be obtained as well.

    专利号:US-2004143125-A1
    优先权日:2003-01-22
    标 题 :Synthesis of dihalohydrins and tri- and tetra-substituted olefins

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    合成参考文献


    参考文献:10.1007/bf00946413
    摘要:Velichko FK, Vinogradova LV. Addition of methyl tribromoacetate and methyl monobromacetate to acrylic compounds. Russian Chemical Bulletin. 1975 Jul;24(7):1459–63. doi: 10.1007/bf00946413.
    参考文献:10.1007/bf00854026
    摘要:Velichko FK, Amriev RA. Addition of methyl dibromoacetate and methyl tribromoacetate to acrylic compounds in the presence of various initiating systems. Russian Chemical Bulletin. 1973 Mar;22(3):567–9. doi: 10.1007/bf00854026.
    参考文献:10.1016/j.chroma.2005.03.129
    摘要:Ma YC, Chiang CY. Evaluation of the effects of various gas chromatographic parameters on haloacetic acids disinfection by-products analysis. J Chromatogr A. 2005 May 27;1076(1-2):216–9. doi: 10.1016/j.chroma.2005.03.129.
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