专利号:WO-2025132814-A1 优先权日:2023-12-21 标 题:Novel synthesis of methyl-2-fluoroacrylate 发明人:BRUNKE JESSICA; FISCHER MICHAEL; WÖSSNER JAN STEPHAN 权利人:VIFOR INT AG 摘要:The present invention relates to novel synthesis methods of methyl 2-fluoroacrylate (MFA) which is a key precursor for the production of Veltassa® (Patiromer). The methods according to the invention are conducted by reacting an α-substituted β-hydroxy propionic acid derivative (I) via one or more intermediate steps involving one or more α-, β-substituted propionic acid derivatives (II) to obtain MFA (III).
专利号:US-7399806-B2 优先权日:2003-06-26 标 题:Synthesis of photoresist polymers 发明人:BENOIT DIDIER; SAFIR ADAM; CHANG HAN-TING; CHARMOT DOMINIQUE; OKAMOTO KENJI; NISHIMURA ISAO; WANG YONG 权利人:SYMYX TECHNOLOGIES INC 摘要:The present invention is directed to the preparation of photoresist polymers via living free radical polymerization techniques. Sterically bulky ester monomers are utilized as the polymerization components. Use of chain transfer agents is included in polymerization processing conditions. Cleavage of polymer terminal end groups that include a heteroatom are described.
专利号:US-11746274-B1 优先权日:2022-02-25 标题 :Ionic liquid monomer for synthesis of friction reducer and methods thereof 发明人:ZHANG XUAN; RUEDA JOSE I; HAN MING; BATAWEEL MOHAMMED; QI ZIYUAN 权利人:SAUDI ARABIAN OIL CO 摘要:A composition includes an ionic liquid monomer having the following structure: n nwhere n is an integer from 1 to 5 and the ionic liquid monomer has a melting point less than 100° C. A method of making the ionic liquid includes providing a mixture comprising a sulfonic acid and a diamine in a solvent, and maintaining the mixture at a temperature ranging from 10 to 80° C. for a time ranging from 1 to 10 hours to form an ionic liquid monomer having a melting point less than 100° C. A method of making a polymer from the ionic liquid monomer is also provided.
专利号:US-9534062-B2 优先权日:2014-07-02 标 题:Synthesis of an acrylate polymer in flow reactor 发明人:HE MINGQIAN; HORN CLEMENS RUDOLF; HU JIEYU; JEAN PATRICK; NIU WEIJUN; SCHISSEL DAVID NEAL; WINNINGHAM MICHAEL JAMES 权利人:CORNING INC 摘要:An improved process for synthesizing acrylic polymers, which is highly controllable to achieve high molecular weight, high conversion rate, and low polydispersity involves continuously introducing initiator(s), acrylic monomer(s), and optionally other monomers capable of polymerizing with the acrylic monomer(s), into a microchannel of a microreactor having an integral micromixer and an integral heat exchanger.
专利号:US-6040440-A 优先权日:1998-03-06 标题:Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives 发明人:GRAHAM ALEXANDRA E; THOMAS ALBERT V; YANG RACHEL R P 权利人:ABBOTT LAB 摘要:A process for the preparation of 4''-deoxyerythromycins, having the formula: wherein R is H or OH, R1 is H or loweralkyl, and R2 is H or CH3 by treatment of the starting material, 2'-O-acetyl-4''-imidazolylthiocarbamoyl-erythromycin, with a hypophosphite reagent, in a water-miscible protic solvent optionally comprising a phase transfer agent. In a preferred embodiment, the water-miscible solvent is an alcohol and the starting material is reacted with sodium hypophosphite, ACVA and tetra-n-butylammonium hydroxide.
专利号:US-6869983-B2 优先权日:2003-06-10 标题:Spatially controlled, in situ synthesis of polymers 发明人:CANEBA GERARD T; TIRUMALA VIJAYA RAGHAVAN; MANCINI DERRICK C; WANG HSIEN-HAU 权利人:UNIV CHICAGO 摘要:An in situ polymer microstructure formation method. The monomer mixture is polymerized in a solvent/precipitant through exposure to ionizing radiation in the absence any chemical mediators. If an exposure mask is employed to block out certain regions of the radiation cross section, then a patterned microstructure is formed. The polymerization mechanism is based on the so-called free-radical retrograde-precipitation polymerization process, in which polymerization occurs while the system is phase separating above the lower critical solution temperature. This method was extended to produce a crosslinked line grid-pattern of poly (N-isopropylacrylamide), which has been known to have thermoreversible properties.
1: Kitayama Y, Isomura M. Gas-stimuli-responsive molecularly imprinted polymer particles with switchable affinity for target protein. Chem Commun (Camb). 2018 Mar 6;54(20):2538-2541. doi: 10.1039/c7cc09889h. doi: 10.1371/journal.pone.0160530. eCollection 2016. 3: Mishra MM, Mishra DK, Mishra P, Behari K. Synthesis and characterization of a novel graft copolymer of partially carboxymethylated guar gum and N-vinylformamide. Carbohydr Polym. 2015 Jan 22;115:776-84. doi: 10.1016/j.carbpol.2012.12.027. Epub 2012 Dec 25. doi: 10.1007/s10517-014-2670-2. Epub 2014 Oct 24. Epub 2007 Aug 14.
合成参考文献
参考文献:10.1002/ijc.1424 摘要:Ameer GA, Crumpler ET, Langer R. Cell-killing potential of a water-soluble radical initiator. Int J Cancer. 2001 Sep;93(6):875–9. doi: 10.1002/ijc.1424. 参考文献:10.1021/la0493464 摘要:González YI, Stjerndahl M, Danino D, Kaler EW. Spontaneous vesicle formation and phase behavior in mixtures of an anionic surfactant with imidazoline compounds. Langmuir. 2004 Aug 17;20(17):7053–63. doi: 10.1021/la0493464.