CAS: 1681-36-3; 4-Chloro-3-Methylpyridine

该化合物是一种环环有机化合物,其特征为4号方位以氯原子替代的环状,3号方位为甲基组.分子式为C6H6ClN,其特征为芳香环内氮原子,有助于其基本性和反应性.该化合物一般是无色的,可粉黄的黄色液体,有独特的味;在有机溶剂中溶解,但由于存在缺水芳香环,在水中溶解性有限.4-Chloloro-3-甲基丙烯被用于各种用途,包括作为合成药品,农用化学品和其他有机化合物的中间体.其再活性可归因于氯亚虫体的电阻性质,影响其电益和核糖特性.在处理该化合物时,应采取安全防范措施,因为若吸入或吸入,可能会对健康造成危害,因此在实验室环境中应采取适当保护措施.

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CAS号626-61-9 4-氯吡啶 | CAS号74-88-4 碘甲烷 | CAS号1074-98-2 3-甲基-4-硝基吡啶-N-氧化物 | CAS号1003-73-2 3-甲基吡啶-N-氧化物 | CAS号67-66-3 氯仿 | CAS号58997-11-8 3-甲基吡啶-4-羧酸 | CAS号1003710-69-7 2-氨基-4-氯-3-羟基-5-甲基吡啶 | CAS号10351-13-0 3-甲基-4-吡啶硫醇 | CAS号1073-34-3 4-氯-3-甲基吡啶-1-氧化物 | CAS号10177-32-9 4-甲氧基烟酸甲酯 | CAS号4021-12-9 3-甲基-4-吡啶羧酸 | CAS号10177-29-4 4-氯烟酸 | CAS号7584-05-6 3-甲基-4-氰基吡啶 | CAS号114913-51-8 4-肼基-3-甲基吡啶 | CAS号915922-09-7 N1-(3-甲基-4-吡啶)-...

合成工艺路线路线简述

    📜3-甲基-4-硝基吡啶-N-氧化物置于盐酸,三氯化磷体系中,用 氯仿 用作溶剂,化学反应 0.33H,以97%的收率获得4-氯-3-甲基吡啶
    参考文献:Syntheses Of Ortho-Hydroxymethylpyridinols And Dioxaphosphorino[m,N-X]Pyridines
    标题:Syntheses Of Ortho-Hydroxymethylpyridinols And Dioxaphosphorino[m,N-X]Pyridines
    摘要:Dioxaphosphorino [m,N-X]Pyridines Compounds Have Been Prepared By Condensation Of Methyl Dichlorophosphate With New Ortho-Hydroxymethylpyridinols.
    Doi:10.1080/00397919608004536

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    专利信息


    专利号:US-8058477-B2
    优先权日:2006-03-21
    标 题 :Process for the synthesis of arylamines from the reaction of an aromatic compound with ammonia or a metal amide
    发明人:HARTWIG JOHN F; SHEN QILONG
    权利人:HARTWIG JOHN F; SHEN QILONG; UNIV YALE
    摘要:A catalytic process for the synthesis of aromatic primary amines, reagent compositions for effecting the process, and transition metal complexes useful in the process, are provided.

    专利号:WO-2024137329-A1
    优先权日:2022-12-20
    标 题:Methods for the synthesis of complement factor d inhibitors and intermediates thereof
    发明人:HASHIMOTO AKIHIRO; TIPPARAJU SURESH KUMAR
    权利人:ALEXION PHARMA INC
    摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.

    专利号:US-7250510-B2
    优先权日:2005-08-24
    标 题:Transition metal complexes of N-heterocyclic carbenes, method of preparation and use in transition metal catalyzed organic transformations
    发明人:ORGAN MICHAEL G; O'BRIEN CHRISTOPHER J; KANTCHEV ASSAM ERIC B
    权利人:TOTAL SYNTHESIS LTD
    摘要:The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.

    专利号:US-8212056-B2
    优先权日:2008-06-30
    标 题 :Ligands for transition-metals and methods of use
    发明人:KWONG FUK YEE; SO CHAU MING
    权利人:KWONG FUK YEE; SO CHAU MING; UNIV HONG KONG POLYTECHNIC
    摘要:The present invention relates to indolyl phosphine ligands, and methods of making such ligands utilizing phenyl hydrazines and aryl ketones as the starting material. The present invention further includes uses of the ligands in the synthesis of pharmaceuticals, materials, and agriculture.

    专利号:US-8853410-B2
    优先权日:2009-04-30
    标 题:Process for preparing substituted isoxazoline compounds and their precursors
    发明人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN
    权利人:RACK MICHAEL; KOERBER KARSTEN; KAISER FLORIAN; BASF SE
    摘要:The present invention relates to a new method of preparing halogenated styrene compounds of formula (VIII) n nwhich are precursors in the process of synthesis of substituted isoxazoline compounds of formula (I)n n nwherein R 1 to R 5 , R 8 and R 9 are described as in the description.n n The present invention relates further to the synthesis of compounds of formula (I) starting from acetophenones. The desired styrenes of formula are prepared from the appropriate substituted acetophenone. Asides bromo anilines react with formoxime. Obtained oximes undergo a cycloaddition with the styrenes and give isoxazolines. Compounds of formula (I) can then be prepared in a palladium catalyzed carbonylative amination reaction of the isoxazolines.

    专利号:US-RE42890-E
    优先权日:2003-05-23
    标题 :Furazanobenzimidazoles
    发明人:EBERLE MARTIN; BACHMANN FELIX; STREBEL ALESSANDRO; ROY SUBHO; SRIVASTAVA SUDHIR; SAHA GOUTAM
    权利人:BASILEA PHARMACEUTICA AG
    摘要:The invention relates to compounds of formula (I) wherein R represents aryl or heteroaryl, X is oxygen, a carbonyl group, an oxime derivative of a carbonyl group or an α,β-unsaturated carbonyl group, and the substituents R 1 to R 6 have the meanings given in the specification, for use as medicaments, to novel compounds of formula (I), to methods of synthesis of such compounds, to pharmaceutical compositions containing compounds of formula (I), to the use of a compounds of formula (I) for the preparation of a pharmaceutical composition for the treatment of neoplastic and autoimmune diseases, and to methods of treatment of neoplastic and autoimmune diseases using such compounds of formula (I) or of pharmaceutical compositions containing same

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    合成参考文献


    参考文献:10.1007/s10822-020-00299-w
    摘要:Kovář P, Škoda J, Pospíšil M, Melánová K, Svoboda J, Beneš L, Kutálek P, Zima V, Bureš F. How N-(pyridin-4-yl)pyridin-4-amine and its methyl and nitro derivatives are arranged in the interlayer space of zirconium sulfophenylphosphonate: a problem solved by experimental and calculation methods. Journal of Computer-Aided Molecular Design. 2020 Feb 12;34(6):683–95. doi: 10.1007/s10822-020-00299-w.
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