CAS: 1678-53-1; 3-Methyl-4-Nitropyridine

相似化合物

1990-90-5 1074-98-2 66092-62-4

上下游产品

CAS号1074-98-2 3-甲基-4-硝基吡啶-N-氧化物 | CAS号1003-73-2 3-甲基吡啶-N-氧化物 | CAS号1990-90-5 4-氨基-3-甲基吡啶 | CAS号109113-39-5 1-苯磺酰基-5-氮杂吲哚 | CAS号100367-58-6 4-硝基吡啶-3-羧酸 | CAS号1990-90-5 4-氨基-3-甲基吡啶 | CAS号271-34-1 1H-吡咯并[3,2-c]吡啶 | CAS号148760-75-2 1-B°C-1H-吡咯并[3,... | CAS号109113-44-2 1-(苯基磺酰基)-1H-吡咯... | CAS号856966-91-1 4-Pyridinol,3-m...

3-甲基-4-硝基吡啶-N-氧化物置于三氯化磷体系中,化学反应 3.5H,以81%的收率获得3-甲基-4-硝基吡啶
参考文献:合成玫瑰果碱工业.I:精制新的6 H-吡啶并[4,3:B]咔唑等类似物:A.Synthèse等人.
标题:合成玫瑰果碱工业.I:精制新的6 H-吡啶并[4,3:B]咔唑等类似物:A.Synthèse等人.
摘要:修饰的玫瑰树碱的全合成,并描述了由11到13步分别由2-氯烟酸和5-甲氧基吲哚和5-氮杂吲哚组成,总收率为11%和18%.还开发了一条通往5-氮杂吲哚的新途径.合成策略要求经常使用均芳族和杂芳族金属化反应,因此必须解决与吡啶环的存在有关的问题.关于文献中描述的大量合成,这种方法的独创性首先在于在碱性介质中形成环c.在图1中,这种条件是由吡啶a环的存在决定的..两种合成方法均已推断出可产生数公斤的最终产物.第一部分涉及前体的制备.
Doi:10.1016/s0040-4020(01)80387-2

专利信息

专利号:US-7468375-B2
优先权日:2004-04-26
标题:Inhibitors of the HIV integrase enzyme
发明人：DRESS KLAUS RUPRECHT; HU QIYUE; JOHNSON TED WILLIAM; PLEWE MICHAEL BRUNO; TANIS STEVEN PAUL; WANG HAI; YANG ANLE; YIN CHUNFENG; ZHANG JUNHU
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus (“HIVâ€?) integrase enzyme.

专利号:US-2009170846-A1
优先权日:2005-10-03
标题 :Inhibitors of the hiv integrase enzyme
发明人：DRESS KLAUS RUPRECHT; PLEWE MICHAEL BRUNO; JOHNSON TED WILLIAM; TANIS STEVEN PAUL; TRAN KHANH TUAN
权利人:PFIZER
摘要:The present invention is directed to compounds of formula (I), and pharmaceutically acceptable salts and solvates thereof, their synthesis, and their use as modulators or inhibitors of the human immunodeficiency virus “HIVâ€? integrase enzyme. Formula (I).

专利号:CN-113354579-A
优先权日:2021-07-15
标题:A kind of high-yield synthesis method of methyl 4-aminonicotinate