对羟基苯乙酮置于硝酸,四丁基碘化铵,Potassium Carbonate体系中,用 溶剂黄146,丙酮 用作溶剂,化学反应生成4-苄氧基-3-硝基苯乙酮 参考文献:2-(3-Benzyloxy-4-Nitrophenyl)Oxirane,An Intermediate In The Synthesis Of Formoterol 标题:2-(3-Benzyloxy-4-Nitrophenyl)Oxirane,An Intermediate In The Synthesis Of Formoterol 摘要: Doi:10.1107/s0108270193014477
专利号:CN-101468954-A 优先权日:2007-12-26 标 题:Asymmetric Hydrogen Transfer Synthesis of (R,R)-Formoterol
专利号:US-6071971-A 优先权日:1998-06-23 标题 :Desformoterol compositions useful for inducing bronchodilation 发明人:SENANAYAKE CHRIS HUGH 权利人:SEPRACOR INC 摘要:The (R,R)-, (S,S)-, (R,S)-, (R,S)-isomers of 3-amino-4-hydroxy-α-[[[2-(4-methoxyphenyl)-1-methylethyl]amino]methyl]-benzenemethanol (D) ##STR1## are disclosed, as well as an efficient method for their stereoselective synthesis. A method and composition are also disclosed utilizing desformoterol (D) as a bronchodilator, having high selectivity for β 2 receptors.
专利号:CN-103664677-A 优先权日:2012-09-05 标 题:A kind of asymmetric synthesis method of (R,R)-formoterol tartrate