CAS: 132834-59-4; 1-[3-Chloro-5-(Trifluoromethyl)Pyridin-2-Yl]Piperazine

相似化合物

1053658-78-8 338792-81-7 338979-38-7

上下游产品

piperazine 2,3-dichloro-5-trifluoromethylpyridine PCM-0102378

📜4-(3-氯-5-三氟甲基吡啶-2-基)哌嗪-1-羧酸叔丁酯置于盐酸体系中,用 1,4-二氧六环 用作溶剂,化学反应生成1-(3-氯-5-三氟甲基吡啶基)哌嗪
参考文献: Gram-Negative Bacteria Efflux Pump Inhibitors[fr] Inhibiteurs De Pompe D'Efflux De Bactéries à Gram Négatif
标题: Gram-Negative Bacteria Efflux Pump Inhibitors[fr] Inhibiteurs De Pompe D'Efflux De Bactéries à Gram Négatif
摘要:The Present Invention Concerns Novel Gram-Negative Bacteria Efflux Pump Inhibitors. It Further Relates To The Use Of Gram-Negative Bacteria Efflux Pump Inhibitors To Prevent And/or Treat Antibiotic Resistance By Potentiating The Activity Of Antibiotics. Infections By Multidrug Resistant (Mdr) Gram-Negative Bacteria Are A Major Threat To Global Healthcare. The Inventors Have Discovered A Novel Class Of Resistance Nodulation Cell Division-Efflux Pump Inhibitors. The Inventors Tested The Effects Of These Inhibitors On Growth Inhibition Of Different Bacteria As Well As Their Impact On The Boosting Of Antibiotic Activity In Different Bacteria. Particularly,The Inventors Tested The Effects Of These Inhibitors On E. Coli,A. Baumannii,K. Pneumoniae And P. Aeruginosa.

专利信息

专利号:US-7812161-B2
优先权日:2007-03-05
标 题 :Synthesis of GlyT-1 inhibitors
发明人：PFLEGER CHRISTOPHE; WALDMEIER PIUS; WANG SHAONING
权利人:HOFFMANN LA ROCHE
摘要:The present invention relates to a process for preparation of a compound of formula I n nwhereinn Het, R 1 , R 2 , R 3 , and n are as defined herein and pharmaceutically acceptable acid addition salts thereof, which comprises reacting a compound of formula 21 with a compound of formula 8 to obtain a compound of formula 11 and coupling the compound of formula 11 in the presence of a coupling reagent or the corresponding acid halogenide with a compound of formula 15 to obtain a compound of formula I.

专利号:WO-2008107334-A2
优先权日:2007-03-05
标题:Process for the synthesis of glyt-1 inhibitors

专利号:AU-2008223915-A1
优先权日:2007-03-05
标题:Process for the synthesis of GLYT-1 inhibitors

专利号:ES-2375585-T3
优先权日:2007-03-05
标题:PROCESS FOR THE SYNTHESIS OF GLYT-1 INHIBITORS.

专利号:US-11279687-B2
优先权日:2010-09-03
标题:Compounds and compositions for the inhibition of NAMPT
发明人：BAIR KENNETH W; BAUMEISTER TIMM R; BUCKMELTER ALEXANDRE J; CLODFELTER KARL H; HAN BINGSONG; LIN JIAN; REYNOLDS DOMINIC J; SMITH CHASE C; WANG ZHONGGUO; ZHENG XIAOZHANG; YUEN PO-WAI
权利人:VALO HEALTH INC; GENENTECH INC
摘要:The present invention relates to compounds and compositions for the inhibition of NAMPT, their synthesis, applications and antidotes. An embodiment of the invention is the provision of a compound of Formula IIIA.

专利号:US-2008221327-A1
优先权日:2007-03-05
标题:Synthesis of glyt-1 inhibitors