CAS: 1162-65-8; Aflatoxin B1

上下游产品

O-methylsterigmat°Cystin norsolorinic acid 2aaflatoxin B2a sterigmat°Cystin 1 8,9-epoxideAflatoxin B1 8,9-epoxide 2aalfatoxin B2a 050668-79-6 -8-(2-amino-1,6-dihydro-6-oxo-7H-purin-7-yl)-2,3-6a,8,9,9a-hexahydro-9-hydroxy-4-methoxycyclopentafurofurobenzopyran-1,11-dione6aS-(6aα,8bβ,9α,9aα)-8-(2-amino-1,6-dihydro-6-oxo-7H-purin-7-yl)-2,3-6a,8,9,9a-hexahydro-9-hydroxy-4-methoxycyclopentafuro3',2':4,5furo2,3-h1benzopyran-1,11-dione

📜O-甲基柄曲菌素置于还原型辅酶ii(Nadph)四钠盐体系中,用 丙酮 用作溶剂,化学反应 84.0H,反应生成黄曲霉毒素 B1
参考文献:Evidence For The Probable Final Steps In Aflatoxin Biosynthesis
标题:Evidence For The Probable Final Steps In Aflatoxin Biosynthesis
摘要:The Final Steps In The Biosynthesis Of The Potent Environmental Carcinogen Aflatoxin B-1 (8) Are Believed To Involve The Oxidative Cleavage And Rearrangement Of O-Methylsterigmatocystin (7) With Loss Of A C-1-Unit. The Means By Which This Overall Transformation occurs Is Not Known And Has Been Addressed Using Cell-Free Conversions Of Samples Of Radiolabeled 7 That Were Obtained By The Incorporation Of Either [1-C-14]-Or [2-C-14]Acetate. The Proportion Of Radioisotope Detected In Aflatoxin B-1 Relative To That Of The C-1-Unit Liberated (Formaldehyde,Formic Acid,Or Carbon Dioxide) Was Tested. [c-14]Carbon Dioxide Alone Was Isolated In The Proper Stoichiometry To Limit The Possible Mechanisms That Can Be Acting At The Conclusion Of This Biosynthetic Pathway.
Doi:10.1021/jo00095A016

专利信息

专利号:US-2018317484-A1
优先权日:2017-05-07
标题:Composition for inhibiting synthesis of mycotoxin without affecting the growth of the fungi
发明人：MEHTA ALKA; BOGA RAMESHBABU; P DHANAMJAYULU
权利人:VIT UNIV; BogaR Laboratories
摘要:A composition for inhibiting the growth of mycotoxins without affecting the growth of fungi is provided. The mycotoxin is an Aflatoxin and the fungus is an Aspergillus . The anti-aflatoxin composition comprises benzimidazole derivatives of Formula, n n n n n n n n n n where the A is hydrogen or C1-C6 alkyl or C6-C14 aryl; B is C1-C10 alkyl or C6-C14 aryl or oxygen, sulfur, nitrogen containing heteroaryl; C and D are hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl; E is hydrogen or nitro or cyano or carboxyl or acetamidoxime or amidoxime or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl; F is hydrogen or C1-C6 alkyl or C1-C6 alkoxyl or C6-C14 aryl or oxygen, sulfur, and nitrogen containing heteroaryl, and mixture thereof with corresponding salts.

专利号:US-2025147014-A1
优先权日:2022-02-14
标题:Plasmon-enhanced fluorescence biochemical sensors
发明人：PINCHUK ANATOLI; SERGEYEVA TETYANA; YARYNKA DARIA; CHEGEL VLADIMIR; LOPATYNSKYI ANDRI
权利人:UNIV COLORADO REGENTS; THE REGENTS OF THE UNIV OF COLORADO A BODY
摘要:A highly sensitive technology enabling selective recognition of aflatoxins such as in contaminated cereal samples. Methods for the synthesis of AgNP-containing MIP membranes from the monomer mixtures containing both methacrylate monomers and oligomers as well as AgNOs solution in dimethylformamide enable the detection system. The AgNP were formed in the structure of the polymeric membranes during the pre-heating step followed by the UV-initiated polymerization. The highly selective sensor elements where MIP membranes are combined with the Ag nanostructures as signal amplifiers (LSPR-MIP nanochips) can be stored separately and used with a simple optical recognition system as selective elements of point-of-care sensor devices, even in in-field conditions. Composite plasmonic membranes provide both highly selective recognition of the target toxin and the generation of an enhanced optical signal, allowing aflatoxin B1 detection at ultralow concentrations.

专利号:US-2022249576-A1
优先权日:2021-02-09
标 题:Method of disrupting mycotoxin synthesis using a composition comprising vibrio gazogenes
发明人：CHANDA ANINDYA
权利人:Mycologics LLC
摘要:A method of inhibiting mycotoxin synthesis in filamentous fungi comprises contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC. Additionally, infections caused by filamentous fungi can be inhibited by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942. Endosomal function in filamentous fungi can be disrupted by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942. Hyphal fusion formation can be restricted in filamentous fungi by contacting the filamentous fungi with a composition comprising Vibrio gazogenes, ATCC 43942.

专利号:US-7449617-B2
优先权日:2004-01-05
标题 :Plants with elevated levels of gallic acid/polyphenol oxidase and methods of generating such plants
发明人：DANDEKAR ABHAYA; MUIR RYANN M
权利人:UNIV CALIFORNIA
摘要:Gallic acid inhibits the synthesis by A. flavus of aflatoxin, a toxic carcinogen that can contaminate crops such as corn, peanuts and walnuts rendering them inedible. The present invention takes advantage of this inhibition to provide various methods and compositions useful for protecting crops from contamination. Gallic acid is also an intermediate in the production of hydrolyzable tannins, which may sequester protein in the rumen, prevent ammonia formation, and allow protein to be more efficiently absorbed in the post-ruminant digestive system. A second gene, polyphenol oxidase (PPO), also from walnut, may act to help sequester protein during ensiling, also protecting and improving nutritional value. The present invention includes non-naturally occurring plants that contain elevated levels of PPO or gallic acid as well as various methods of generating such plants. The present invention further provides methods of application of gallic acid to prevent contamination. In addition, the present invention provides certain genes and proteins that are be useful in making the non-naturally occurring plants.

专利号:US-7365178-B2
优先权日:2003-04-01
标 题:Acyl-nucleotide probes and methods of their synthesis and use in proteomic analysis
发明人：CAMPBELL DAVID ALAN; LIYANAGE MAREK; SZARDENINGS ANNA KATRIN; WU MIN
权利人:ACTIVX BIOSCIENCES INC
摘要:The present invention provides tagged acyl phosphate probes (“TAPPsâ€?), and methods of their preparation and use. The subject methods and compositions can provide enhanced simplicity and accuracy in identifying changes in the presence, amount, or activity of target proteins in a complex protein mixture, preferably nucleotide binding proteins using nucleotide binding protein-directed TAPPs. The profiling methods described herein can have a number of steps leading to the identification of target nucleotide binding protein(s) in a complex protein mixture.

专利号:US-11078468-B2
优先权日:2015-04-01
标题:Microbiological production of short fatty acids and uses thereof
发明人：GRININGER MARTIN; GAJEWSKI JAN; BOLES ECKHARD; PAVLOVIC RENATA
权利人:JOHANN WOLFGANG GOETHE UNIV FRANKFURT AM MAIN
摘要:The present invention relates to proteins involved in fatty acid synthesis, such as fatty acid synthases (FAS) variants, comprising one or more polypeptide chains, wherein said polypeptide chain(s) comprise one or more subunits comprising a malonyl/palmitoyl transferase domain (MPT domain), acetyl transferase domain (AT domain), and ketoacyl synthase domain (KS domain), and at least one amino acid substitution in the MPT domain at a position corresponding to R130, in the AT domain at a position corresponding to I306, and/or in the KS domain, preferably in the acyl binding channel and/or at KS domain binding site to ACP, to modulate affinities of acyl intermediates, and optionally further amino acid substitution(s). The present invention relates to the respective polypeptide domains. The present invention further relates to nucleic acid molecules encoding the proteins (or the polypeptide domains) and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of short fatty acids, CoA esters of short fatty acids, ethyl esters of short fatty acids, esters of short fatty acids with other metabolites, and/or enzyme bound short fatty acids (C6 to C12), comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention further relates to a method for the production of biofuels, flavoring compounds and/or fine chemicals, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the proteins, nucleic acids molecule or host cells for the bulk production of short fatty acids (C6 to C12), the specific production of C6 fatty acids and/or C8 fatty acids, the bulk production of CoA esters of short fatty acids (C6 to C12), the specific production of C6-CoA esters and/or C8-CoA esters, the bulk production of ethyl esters of short fatty acids (C6 to C12), the specific production of C6 fatty acid ethyl esters and/or C8 fatty acid ethyl esters, the bulk production of esters of short fatty acids (C6 to C12) with other metabolites, the specific production of C6 fatty acid esters with other metabolites and/or C8 fatty acid esters with other metabolites, the bulk production of enzyme bound short fatty acids (C6 to C12), the specific production of enzyme bound C6 fatty acids and/or enzyme bound C8 fatty acids, the production of biofuels, fine chemicals and/or flavoring substances.