CAS: 115619-01-7; 4-(4-Ethylpiperazin-1-yl)Phenylamine

相似化合物

16153-81-4 1172518-57-8 2009011-61-2

上下游产品

CAS号115619-00-6 1-乙基-4-(4-硝基苯基)哌嗪 | CAS号5308-25-8 N-乙基哌嗪 | CAS号636-98-6 4-硝基碘苯 | CAS号586-78-7 对溴硝基苯 | CAS号100-00-5 对硝基氯苯

4-硝基碘苯置于palladium 10% On Activated Carbon,氢气,Palladium Diacetate,Caesium Carbonate,R-(+)-1,1'-联萘-2,2'-双二苯膦体系中,用 甲苯 用作溶剂,90.0 °C,344.75 Kpa 条件下,反应生成4-(4-乙基哌嗪-1-基)苯胺
参考文献:在9-氨基位置带有碱性苯基残基的功能化奎纳克林类似物的抗-病毒活性和类药物潜力
标题:在9-氨基位置带有碱性苯基残基的功能化奎纳克林类似物的抗-病毒活性和类药物潜力
摘要:在本文中,我们报道了用4-(4-甲基哌嗪-1-基)苯基,(1-苄基哌啶-4-Yl)及其结构变体.发现在不同different病毒感染的鼠细胞模型的效价和活性方面,一些有前途的类似物在抗病毒方面比奎纳克林更有利.它们还表现出对人类病毒蛋白片段的更高结合亲和力(hprp 121-231)比奎纳克林高,并且在pampa-Bbb分析中的渗透率在cns渗透候选物范围内.当在过表达pgp的细胞系上进行双向分析评估时,与奎纳克林相比,一种类似物对pgp外排活性的敏感性较低.两者合计,结果表明连接到a啶,四氢ac啶和喹啉骨架上的取代9-氨基侧链的重要作用.该侧链的性质影响基于细胞的效能,Pampa渗透性和对hprp 121-231的结合亲和力.
Doi:10.1016/j.Ejmech.2011.04.016

专利信息

专利号:US-8030311-B2
优先权日:2005-04-14
标题:Phenylacetamides suitable as protein kinase inhibitors
发明人：BOLD GUIDO; FURET PASCAL; GUAGNANO VITO; MCCARTHY CLIVE; VAUPEL ANDREA
权利人:NOVARTIS AG
摘要:The invention relates to compounds of the formula (I) wherein the moieties R1, R2, R3, R9, R10 and Q and X, Y and Z are as defined in the specification, and salts thereof, as well as their use, methods of use for them and method of their synthesis, and the like. The compounds are protein kinase inhibitors and can, inter alia, be used in the treatment of various proliferative diseases.

专利号:CN-110092798-A
优先权日:2018-01-29
标题:A kind of heterocyclic compound as FGFR inhibitor and its synthesis method and application