CAS: 106308-44-5; 1-(2,6-Difluorobenzyl)-1H-1,2,3-Triazole-4-Carboxamide

上下游产品

2-(azidomethyl)-1,3-difluorobenzene 2-Chloroacrylonitrile CGP 47292 methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate

2-(叠氮甲基)-1,3-二氟苯置于ammonium Hydroxide,三乙胺体系中,用 甲醇,水 用作溶剂,化学反应 66.0H,反应生成卢非酰胺
参考文献:抗癫痫药1-(2,6-二氟苄基)-1 H-1,2,3-三唑-4-羧酰胺(rufinamide)及其类似物的新无溶剂和无金属合成
标题:抗癫痫药1-(2,6-二氟苄基)-1 H-1,2,3-三唑-4-羧酰胺(rufinamide)及其类似物的新无溶剂和无金属合成
摘要:这项工作提出了一种抗癫痫药芦丁酰胺的新合成形式-化学形式的1-(2,6-二氟苄基)-1 H-1,2,3-三唑-4-羧酰胺)和一些类似的化合物,锅式反应采用无溶剂,无金属的催化,不需任何还原剂.提出的一个新奇的东西是从苯甲酸合成新的前体物4-三氯乙酰-1-(2,6-二氟苄基/苄基/ 4-甲氧基苄基)-5-甲基(苯基)-1 H-1,2,3-三唑. 1,1,1-三氯-4-烷氧基烷-3-En-2-Ones和一些苄基叠氮化物之间的区域选择性1,3-偶极环加成反应,通过与水溶液的加成-消除反应转化为芦丁酰胺和类似物nh 4溶液oh的收率很高(42-52%).
Doi:10.1016/j.Tetlet.2014.11.125

专利信息

专利号:US-2023173450-A1
优先权日:2020-04-28
标题:Automated chemical synthesis platform
发明人：CRONIN LEROY; MEHR HESSAM; CRAVEN MATTHEW; LEONOV ARTEM
权利人:UNIV GLASGOW COURT
摘要:The invention provides a method for controlling an automated chemistry platform using synthetic procedures written in natural language. The method uses natural language processing (NLP) techniques to interpret a synthetic procedure written in natural scientific language and extracts a machine-readable instruction set comprising the distinct operations necessary for carrying out the synthesis on an automated chemical synthesis platform. The method optionall also includes the step of executing the machine-readable instruction set on an automated chemical synthesis platform.

专利号:WO-2025017001-A1
优先权日:2023-07-18
标题 :Method and device for automation of chemical synthesis
发明人：CHATTERJEE SOURAV; MOON SOOYEON
权利人:CHATTERJEE SOURAV; MOON SOOYEON
摘要:The present disclosure relates to a chemical synthesizer (1) and a method for performing a chemical synthesis on a chemical synthesizer (1), the chemical synthesizer comprising an automated chemical reactor (12), a communication module (13), and a control module (11), the method comprising receiving, in the control module (11) using the communication module (13), a recipe message from a blockchain platform, the recipe message comprising an encrypted chemical synthesis recipe; decrypting, in the control module (11), the encrypted chemical synthesis recipe using a cryptographic key securely stored in the control module (11); and performing, in the automated chemical reactor (12), the chemical synthesis according to the chemical synthesis recipe.

专利号:RU-2177942-C2
优先权日:1996-07-11
标 题:Method of synthesis of 1-substituted 4-cyano-1,2,3-triazoles and 4-cyano-1-(2,6-difluorobenzyl)-1h-1,2,3-triazole

专利号:US-2023149882-A1
优先权日:2020-04-17
标题:Fluid handling device and methods
发明人：CRONIN LEROY
权利人:UNIV GLASGOW COURT
摘要:Provided is a fluid handling device having multiple flow pathways through the device. The device has a fluid directing manifold comprising an array of interconnected multi-directional valves, and a plurality of ports in fluid connection with the array. The device also has a controller to set the position of the multi-directional valves. The manifold is configured to provide at least two independent flow paths between a pair of ports within the manifold. Also provided is a method of using the device, and an automated chemical synthesis platform comprising the device.

专利号:US-11459325-B2
优先权日:2018-01-31
标题:Heterocyclic compound
发明人：TANAKA YUTA; OHASHI TOMOHIRO; IKEDA ZENICHI; TANAKA YUTA; PÃœNNER FLORIAN; YAMAMOTO TAKESHI; KAKEGAWA KEIKO; KIKUCHI FUMIAKI; MORISHITA NAO; KASAHARA TAKAHITO; SETO MASAKI; NAKAMURA MINORU; TAKAMI KAZUAKI; MURAKAMI MASATAKA; DAINI MASAKI; MIKAMI SATOSHI; SASAKI MINORU
权利人:TAKEDA PHARMACEUTICALS CO
摘要:The present invention provides a compound having a glucosylceramide lowering action (e.g., promoting glucosylceramide metabolism, inhibition of glucosylceramide synthesis, promoting glucosylceramide catabolism, etc.), which is expected to be useful as an agent for the prophylaxis or treatment of lysosome diseases (e.g., Gaucher's disease), neurodegenerative diseases (e.g., Parkinson's disease, Lewy body dementia, multiple-system atrophy) and the like. n The present invention relates to a compound represented by the formula (I): n nwherein each symbol is as described in the specification, or a salt thereof.

专利号:CN-107141235-B
优先权日:2017-06-21
标 题 :A kind of method and its drug of the lower synthesis benzyl azide of blue light excitation