CAS: 99-23-0; 3,4,6-Trihydroxy-5-Oxocyclohepta-1,3,6-Triene-1-Carboxylic Acid

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Stipitatic Acid 4440-39-5
4-Hydroxy-5,6-Dimethoxy-3-Oxocyclohepta-1,4,6-Triene-1-Carboxylic Acid 152944-94-0
Puberulonic Acid 82-83-7
2,3-O-Isopropylidene-5-Formyltropolone 1616956-68-3

(3S,4S,5S)-3,4-O-Isopropylidene-5,6-Dihydroxy-1-(P-Methoxybenzyloxy)Methylcyclohept-1-Ene置于sodium Chlorite,Sodium Dihydrogenphosphate Dihydrate,2-甲基-2-丁烯,氢溴酸,三氧化硫吡啶,溶剂黄146,二甲基亚砜,三乙胺,2,3-二氯-5,6-二氰基-1,4-苯醌体系中,用 四氢呋喃,二氯甲烷,水,叔丁醇 作为反应溶剂,化学反应 36.08H,反应生成 4,5,6-三羟基-3-氧代-1,4,6-环庚三烯-1-羧酸
参考文献:A Concise Total Synthesis Of Puberulic Acid,A Potent Antimalarial Agent
标题:A Concise Total Synthesis Of Puberulic Acid,A Potent Antimalarial Agent
摘要:通过8个步骤,使用d-(+)-半乳糖作为框架来源,成功合成了毛果酸,收率为54%.
DOI:10.1039/c4Cc03134B