CAS: 89364-04-5; 3-Bromo-4-Nitropyridine

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13534-98-0 1678-49-5 1378873-37-0

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CAS号1678-49-5 3-溴-4-硝基吡啶 N-氧化物 | CAS号77200-37-4 [3,3'-Bipyridin... | CAS号99839-30-2 3-溴-4-氯吡啶1-氧化物

3-溴-4-硝基吡啶-N-氧化物置于[reocl3(Pph3)2],三苯基膦体系中,用 二氯甲烷 作为反应溶剂,化学反应 6.0H,反应生成 3-溴-4-硝基吡啶
参考文献:一锅两步自动合成[18F] T807注射剂,其在小鼠和猴子中的生物分布以及在人体中的初步研究.
标题:一锅两步自动合成[18F] T807注射剂,其在小鼠和猴子中的生物分布以及在人体中的初步研究.
摘要:[18F] T807是有效的tau蛋白显像剂.为了满足临床前和临床研究的需求,我们开发了这种强效tau成像剂的自动一锅两步合成方法,并研究了其稳定性以及在小鼠和猴子中的剂量测定.我们还对该人类成像剂进行了初步研究.使用这种一锅两步法,在轰击(eob)结束后的70+/-5分钟合成时间内,[18F] T807的放射化学产率(rcy)为20.5+/-6.1%(n = 15).化学和放射化学纯度> 90%,比活度为151+/-52 Gbq /μmol.通过这种方法合成的[18F] T807的质量符合美国药典(usp)的标准.稳定性测试表明,[18F] T807注射液在合成(eos)结束后在室温下稳定长达4小时.从猴子推断的[18F] T807注射的估计有效剂量为19μsv/ Mbq(n = 2),而从禁食和非禁食的小鼠推断的[18F] T807注射的估计有效剂量为123+/-27(N = 3)和94+/-19(n =
DOI:10.1371/journal.Pone.0217384

专利信息

专利号:US-2017355648-A1
优先权日:2016-04-26
标题 :Synthesis of meta-substituted [18f]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine n-oxides

专利号:US-10160695-B2
优先权日:2016-04-26
标 题 :Synthesis of meta-substituted [18F]-3-fluoro-4-aminopyridines by direct radiofluorination of pyridine N-oxides
发明人：BRUGAROLAS PEDRO
权利人:UNIV CHICAGO
摘要:Disclosed herein are methods for the fluorination aromatic N-heterocyclic N-oxides that comprise at least one leaving group. The N-oxides may be reduced to the fluorinated aromatic N-heterocyclic amine analogs. This novel fluorination approach may be successfully applied for synthesizing aromatic N-heterocyclic compounds labeled with 18 F.

专利号:CN-117683016-A
优先权日:2022-09-05
标 题:Synthesis of Chiral 3,4-Disubstituted Aminopyridine Catalyst and Its Application in Black Rearrangement

专利号:US-8524905-B2
优先权日:2007-05-22
标 题:Processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of PDE IV inhibitors
发明人：GHARAT LAXMIKANT ATMARAM; GAJERA JITENDRA MAGANBHAI; PATIL SANDIP DAMODAR; KADAM SURESH M
权利人:GHARAT LAXMIKANT ATMARAM; GAJERA JITENDRA MAGANBHAI; PATIL SANDIP DAMODAR; KADAM SURESH M; GLENMARK PHARMACEUTICALS SA
摘要:The present invention relates to novel processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, which is a novel and useful intermediate for preparing compounds with PDE4 inhibitory activity, such as 3,5-dichloro-4-(6-difluoromethoxybenzo[4,5]furo[3,2-c]pyridin-9-ylcarboxamido)-1-pyridiniumolate.

专利号:WO-2008142542-A2
优先权日:2007-05-22
标 题:Processes for preparing benzofuro [3, 2-c] pyridine- 9-carbaldehyde derivatives as novel intermediates for the synthesis of pde iv inhibitors

专利号:US-2010168151-A1
优先权日:2007-05-22
标 题 :Novel processes for preparing 6-(difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carbaldehyde, a novel intermediate for the synthesis of pde iv inhibitors