CAS: 869-19-2; (S)-2-(2-Aminoacetamido)-4-Methylpentanoic Acid

该化合物是一种由氨基酸甘油和素组成的二极酸,其特征为结构结构,其特点是通过浸泡物结合,与液态残留物相连的甘油残留物.该化合物表面上一般为白色,表面为白,在水中可溶解,反映氨基硫酸成分的极性.甘油-L-莱基尼因其在各种生物化学过程中的作用而著称,可用于与浸泡合成和蛋白研究有关的研究中.它可能展示生物活动,包括代谢和细胞信号中的潜在作用.甘基-液素的稳定性可能受到诸如pH和温度等因素的影响,这些因素是实验应用中的重要考虑因素.作为浸泡剂,它也可以作为更大的peptide和蛋毒剂的建筑块,使其在生物化学和分子生物学领域具有重要意义.

结构式图片

相似化合物

688-13-1 51871-42-2 2171289-23-7

物理性质

MSDS等安全信息

上下游产品

CAS号2666-93-5 methyl L-leucinate | CAS号61-90-5 L-亮氨酸 | CAS号6707-71-7 L-Leucine,N-[(1... | CAS号15050-24-5 benzyl N-(2-chl... | CAS号1421-69-8 Z-Gly-Leu-OH | CAS号7352-21-8 Cbz-glycylleuci... | CAS号61-90-5 L-亮氨酸 | CAS号14379-80-7 Aminoacetic aci... | CAS号56-40-6 甘氨酸 | CAS号29852-55-9 N-乙酰基甘氨酰亮氨酸 | CAS号1421-69-8 Z-Gly-Leu-OH | CAS号688-12-0 N-氯乙酰-L-亮氨酸

合成工艺路线路线简述

  • 869-19-2 = 869-19-2
    反应条件:1.1 Reagents: Sodium Nitrate Solvents: Water; 25 °C
    标题:Potentiometric Studies Of Ternary Complexes Involving Ethylenediamine N,N'-Diacetic Acid (Edda) Palladium(Ii) And Some Bioligands
    作者:Ammar,R. A. A.
    参考文献:Fluid Phase Equilibria 日期:2009 卷标:285(1-2) 页码:116-121]

    869-19-2 = 869-19-2
    反应条件:1.1 Reagents: Sodium Hydroxide,Sodium Nitrate Solvents: Water; 25 °C
    标题:Equilibrium Studies On Complex-Formation Reactions Of Pd[(2-(2-Aminoethyl)Pyridine)(H2O)2]2+ With Ligands Of Biological Significance And Displacement Reactions Of Dna Constituents
    作者:Shehata,Mohamed R.; Et Al
    参考文献:European Journal Of Inorganic Chemistry 日期:2009 卷标:(26) 页码:3912-3920]

    29022-11-5 + 35661-60-0 = 869-19-2
    反应条件:1.1 Rt1.2 Reagents: Piperidine Solvents: Dimethylformamide; Rt1.3 Reagents: Ethyl 2-Cyano-2-(Hydroxyimino)Acetate,Diisopropylethylamine,Pybop Solvents: Dimethylformamide; 1 H,Rt1.4 Reagents: Piperidine Solvents: Dimethylformamide; Rt1.5 Reagents: Trifluoroacetic Acid; Rt
    标题:Site-Selective,Late-Stage C-H 18F-Fluorination On Unprotected Peptides For Positron Emission Tomography Imaging
    作者:Yuan,Zheliang; Et Al
    参考文献:Angewandte Chemie 日期:2018 卷标:57(39) 页码:12733-12736]

    54793-73-6 = 869-19-2
    反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 5 Min,Rt; 5 Min,Rt1.2 Reagents: Acetic Acid Solvents: Water; Ph 7 - 8,Rt
    标题:Design,Synthesis And Sar Studies Of Tripeptide Analogs With The Scaffold 3-Phenylpropane-1,2-Diamine As Aminopeptidase N/cd13 Inhibitors
    作者:Shang,Luqing; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2009 卷标:17(7) 页码:2775-2784]

    61-90-5 + 56-40-6 = 869-19-2
    反应条件:1.1 Catalysts: Alumina Solvents: Water
    标题:Preferential Amino Acid Sequences In Alumina-Catalyzed Peptide Bond Formation
    作者:Bujdak,J.; Et Al
    参考文献:Journal Of Inorganic Biochemistry 日期:2002 卷标:90(1-2) 页码:1-7]

    = 869-19-2
    反应条件:1.1 Reagents: Silver Nitrate Solvents: Water2.1 Reagents: Sodium Nitrate Solvents: Water; 25 °C
    标题:Potentiometric Studies Of Ternary Complexes Involving Ethylenediamine N,N'-Diacetic Acid (Edda) Palladium(Ii) And Some Bioligands
    作者:Ammar,R. A. A.
    参考文献:Fluid Phase Equilibria 日期:2009 卷标:285(1-2) 页码:116-121]

    7517-19-3 + 56-40-6 = 869-19-2
    反应条件:1.1 Reagents: 4-Methylmorpholine,Isobutyl Chloroformate Solvents: Tetrahydrofuran; 30 Min,-15 °C1.2 1 H,-15 °C; 4 H,-15 °C -> Rt2.1 Reagents: Sodium Hydroxide Solvents: Methanol,Water; 5 Min,Rt; 5 Min,Rt2.2 Reagents: Acetic Acid Solvents: Water; Ph 7 - 8,Rt
    标题:Design,Synthesis And Sar Studies Of Tripeptide Analogs With The Scaffold 3-Phenylpropane-1,2-Diamine As Aminopeptidase N/cd13 Inhibitors
    作者:Shang,Luqing; Et Al
    参考文献:Bioorganic & Medicinal Chemistry 日期:2009 卷标:17(7) 页码:2775-2784]

    63443-82-3 = 869-19-2
    反应条件:1.1 Reagents: Water,Silver Nitrate2.1 Reagents: Sodium Hydroxide,Sodium Nitrate Solvents: Water; 25 °C
    标题:Equilibrium Studies On Complex-Formation Reactions Of Pd[(2-(2-Aminoethyl)Pyridine)(H2O)2]2+ With Ligands Of Biological Significance And Displacement Reactions Of Dna Constituents
    作者:Shehata,Mohamed R.; Et Al
    参考文献:European Journal Of Inorganic Chemistry 日期:2009 卷标:(26) 页码:3912-3920]

    2706-56-1 = 869-19-2
    反应条件:1.1 Reagents: Potassium Chloride,Palladium Chloride Solvents: Water; 30 Min,70 °C; 70 °C -> 25 °C1.2 Solvents: Water; Ph 2 - 3,25 °C2.1 Reagents: Water,Silver Nitrate3.1 Reagents: Sodium Hydroxide,Sodium Nitrate Solvents: Water; 25 °C
    标题:Equilibrium Studies On Complex-Formation Reactions Of Pd[(2-(2-Aminoethyl)Pyridine)(H2O)2]2+ With Ligands Of Biological Significance And Displacement Reactions Of Dna Constituents
    作者:Shehata,Mohamed R.; Et Al
    参考文献:European Journal Of Inorganic Chemistry 日期:2009 卷标:(26) 页码:3912-3920]

    5657-17-0 = 869-19-2
    反应条件:1.1 Reagents: Potassium Chloride,Palladium Chloride Solvents: Water; 30 Min,Rt -> 50 °C; Cooled1.2 Solvents: Water; Rt; 1 H,25 °C2.1 Reagents: Silver Nitrate Solvents: Water3.1 Reagents: Sodium Nitrate Solvents: Water; 25 °C
    标题:Potentiometric Studies Of Ternary Complexes Involving Ethylenediamine N,N'-Diacetic Acid (Edda) Palladium(Ii) And Some Bioligands
    作者:Ammar,R. A. A.
    参考文献:Fluid Phase Equilibria 日期:2009 卷标:285(1-2) 页码:116-121]

    61-90-5 + 56-40-6 = 869-19-2 + 686-50-0
    反应条件:1.1 Solvents: Water; 22 Mpa,379 °C
    标题:Study On Condensation Of Amino Acid In Super Critical Water Fluid
    作者:Harada,Osamu; Et Al
    参考文献:Hyogo-Kenritsu Kogyo Gijutsu Senta Kenkyu Hokokusho 日期:2003 卷标:12
N-Trifluoracetyl-Glycyl-L-Leucin置于ammonium Hydroxide体系中,化学反应生成 甘氨酰-L-亮氨酸
参考文献:Weygand; Roepsch,Chemische Berichte,1959,Vol. 92,P. 2095,2098
标题:Weygand; Roepsch,Chemische Berichte,1959,Vol. 92,P. 2095,2098

海关参考信息

专利信息


专利号:US-3846399-A
优先权日:1969-04-10
标题:Process for controlled stepwise synthesis of polypeptides
发明人：HIRSCHMANN R; DENKEWALTER R
权利人:MERCK & CO INC
摘要:The invention disclosed herein relates to a novel process for the controlled, stepwise synthesis of polypeptides and proteins. More particularly, it is concerned with a process for the rapid and efficient preparation of polypeptides in which multiple sequential steps are carried out without isolation of intermediate peptides. This process for the controlled stepwise synthesis of polypeptides involves reacting a starting amino acid or peptide (or derivative thereof) with an N-carboxy amino acid anhydride (or derivative thereof) in an aqueous medium under conditions of controlled pH such that the only amino group present in appreciable concentration in reactive form during the course of the reaction is the amino group in the starting amino acid or peptide.

专利号:US-4242256-A
优先权日:1977-03-15
标 题 :Synthesis of peptide analogues
发明人：SHARPE ROBERT; SZELKE MICHAEL
权利人:SHARPE ROBERT; SZELKE MICHAEL
摘要:Compounds being analogues of a dipeptide in which the nitrogen atom of the linking amide group of the dipeptide is replaced by trivalent group ##STR1## and in which, optionally, the carbonyl function of this linking group is replaced by the divalent group --CH 2 -- are of value in the synthesis of isosterically modified peptides.

专利号:EP-2588602-A1
优先权日:2010-07-01
标题:Variants of glucoamylase
发明人：DEGN PETER EDVARD; BOTT RICHARD R; VROEMEN CASPER WILLEM; SCHEFFERS MARTIJN SILVAN; AEHLE WOLFGANG; PETERSEN ELIN
权利人:DUPONT NUTRITION BIOSCI APS; DANISCO US INC
摘要:The present invention relates to combinatorial variants of a parent glucoamylase that have altered properties for reducing the synthesis of condensation products during hydrolysis of starch. Accordingly the variants of a parent glucoamylase are suitable such as for use within brewing and glucose syrup production. Also disclosed are DMA constructs encoding the variants and methods of producing the glucoamylase variants in host cells.

专利号:US-6534627-B1
优先权日:1989-10-23
标题:Synthesis and use of amino acid fluorides as peptide coupling reagents
发明人：CARPINO LOUIS A; EL-FAHAM AYMAN AHMED
权利人:RES CORP TECHNOLOGIES INC
摘要:The present invention is directed to the process of preparing a peptide comprising reacting a first amino acid or peptide with an amino acid fluoride of the formula: n or the acid fluoride salts thereof wherein n BLK is an N-amino protecting group; n AA is an amino acid residue; and n X is absent or a protecting group. n The amino acid fluoride is useful as a coupling agent in peptide synthesis.

专利号:US-3778427-A
优先权日:1971-11-02
标 题 :Hexapeptide
发明人：FLOURET G
权利人:ABBOTT LAB
摘要:THE SYNTHESIS OF THE HEXAPEPTIDE TYR-GLY-LEU-ARG-PROGLY-AMIDE CARRYING EASILY REMOVABLE PROTECTIVE GROUPS ON THE TYR AND ARG MOIETIES IS DESCIRBED; THE CORRESPONDINGLY PROTECTED PENTAPEPTIDE IS USED AS THE STARTING MATERIAL. THE HEXAPEPTIDE, UPON REMOVAL OF ANY PROTECITVE GROUP ON THE NITROGEN OF THE TYROSINE MOEITY, IS AN IMPORTANT INTERMEDIATE FOR THE PREPARATION OF THE GONADOTROPIN-RELEASING HORMONE.

专利号:US-3790554-A
优先权日:1971-09-24
标题:Heptapeptide intermediate to gonadotropin-releasing hormone
发明人：FLOURET G
权利人:ABBOTT LAB
摘要:THE SYNTHESIS OF THE HEPTAPEPTIDE SER-TYR-CLY-LEUARG-PRO-GLY-AMIDE CARRYING EASILY REMOVABLE PROTECTIVE GROUPS ON THE SER, TYR AND ARG MOIETIES IS DESCRIBED; THE CORRESPONDINGLY PROTECTED HEXAPEPTIDE IS USED AS THE STATING MATERIAL. THE HEPTAPEPTIDE, UPON REMOVAL OF ANY PROTECTIVE GROUP ON THE AMINO-N OF THE SERINE MOIETY, IS AN IMPORTANT INTERMEDIATE FOR THE PEPARATION OF THE GONADOTROPIN-RELEASING HORMONE.

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主要参考文献


1: Lochs H, Williams PE, Morse EL, Abumrad NN, Adibi SA. Metabolism of glycylleucine and its constituent amino acids by liver, muscle, kidney and gut in conscious dogs. Beitr Infusionther Klin Ernahr. 1987;17:167-70.
6: Lee AJ, Beno DW, Zhang X, Shapiro R, Mason M, Mason-Bright T, Surber B, Edens NK. A (14)C-leucine absorption, distribution, metabolism and excretion (ADME) study in adult Sprague-Dawley rat reveals β-hydroxy-β-methylbutyrate as a metabolite. Amino Acids. 2015 May;47(5):917-24. doi: 10.1007/s00726-015-1920-6. Epub 2015 Jan 25.
7: Adibi SA, Soleimanpour MR. Functional characterization of dipeptide transport system in human jejunum. J Clin Invest. 1974 May;53(5):1368-74.

合成参考文献


摘要:Zefirov, N. S.; Matveeva, E. D.; Shuvalov, M. V., Science of Synthesis: Multicomponent Reactions, (2013) 1, 282.
摘要:E. J. King. J. Am. Chem. Soc. 79, 6151 (1957).
摘要:H. Dobbie and W. O. Kermack. Biochem. J. 59, 246 (1955).
参考文献:10.1021/jm0511029
摘要:Vig BS, Stouch TR, Timoszyk JK, Quan Y, Wall DA, Smith RL, Faria TN. Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem. 2006 Jun 15;49(12):3636–44. doi: 10.1021/jm0511029.
参考文献:10.1023/b:pham.0000008036.05892.e9
摘要:Uchiyama T, Kulkarni AA, Davies DL, Lee VH. Biophysical evidence for His57 as a proton-binding site in the mammalian intestinal transporter hPepT1. Pharm Res. 2003 Dec;20(12):1911–6. doi: 10.1023/b:pham.0000008036.05892.e9.
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