CAS: 771-12-0; 2-Oxo-2-(2-Oxocyclohexyl)Acetic Acid

上下游产品

cyclohexanone oxalic acid diethyl ester (R)-Hydroxy-(2-oxo-cyclohexyl)-acetic acid ethyl 2-oxo-2-(2-ox°Cyclohexyl)acetate 4,5,6,7-tetrahydro-1H-indazole-3-carboxylic acid p-tolyl-3-p-tolylimino-1,3,4,5,6,7-hexahydro-indol-2-one1-p-tolyl-3-p-tolylimino-1,3,4,5,6,7-hexahydro-indol-2-one 1-(3,4-dimethoxy-phenethyl)-3-(3,4-dimethoxy-phenethylimino)-1,3,4,5,6,7-hexahydro-indol-2-one

📜(R)-Hydroxy-(2-Oxo-Cyclohexyl)-Acetic Acid置于benzylviologen Cation Radical体系中,用 水 作为反应溶剂,化学反应生成 2-二氧代环己烷乙酸
参考文献:通过用氢气或甲酸盐还原2-羟肟酸和寻常变形杆菌的多官能团()-2-羟基羧酸
标题:通过用氢气或甲酸盐还原2-羟肟酸和寻常变形杆菌的多官能团()-2-羟基羧酸
摘要:各种()-2-羟基酸如()-2-羟基-3-烯酸,3,5-二烯酸,4-氧代,()-3-羟基等,其制备规模可达到通过以寻常的毕赤酵母和氢气和/或甲酸作为电子给体,对相应的2-氧代酸进行生物催化还原,可得到0.12摩尔.除2-羟基-4-氧代酸外,可以证明对映体过量> 97%.对于4-氧代衍生物,可以假定该对映体过量.分离出的产物的产率很高,因为它们是从相当少量的生物催化剂中分离出来的,并且缓冲液的浓度很低,获得的产物浓度在0.1-0.24 M的范围内.在15-20小时内形成1 Mmol的产品,约20-40 Mg(干重)寻常型毕赤酵母 单元格是必需的.
DOI:10.1016/s0040-4020(01)86506-6

专利信息

专利号:US-4256639-A
优先权日:1978-06-23
标题:Process for the synthesis of isatin derivatives
发明人：BAIOCCHI LEANDRO
权利人:ACRAF
摘要:Process for the preparation of the 2-(2,6-dichloroanilino)-phenylacetic acid which comprises, as a basic step, the heating of a mixture containing a pyridic base, an organic or inorganic acid and 4,5,6,7-tetrahydro-N-(2,6-dichlorophenyl)-isatin or its O-acyl or O-alkyl derivatives.