CAS: 72320-38-8; 3-Azidopropan-1-Ol

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1-bromo-3-propanol acrolein 1-chloro-3-hydroxypropane 2-(3-azidopropoxy)tetrahydro-2H-pyran 5,6-dihydro-2-(3-nitrophenyl)-4H-1,3-oxazine 2-Phenyl-5,6-dihydro-4H-[1,3]oxazine 2-(p-methylphenyl)-5,6-dihydro-4H-1,3-oxazine H-[1,3]oxazine2-(4-fluoro-phenyl)-5,6-dihydro-4H-[1,3]oxazine

📜2-氯乙醇置于sodium Azide体系中,用 水 作为反应溶剂,化学反应 22.0H,反应生成 3-叠氮基丙醇
参考文献:含硒紫杉醇二聚体前药聚合物纳米粒及其制 备方法
标题:含硒紫杉醇二聚体前药聚合物纳米粒及其制 备方法
摘要:本发明属于药物制剂领域,涉及一种含硒紫杉醇二聚体前药聚合物纳米粒及其制备方法本发明的制剂由含硒紫杉醇二聚体前药,聚乙二醇‑聚苯丙胺酸两亲性聚合物材料及多肽修饰的聚乙二醇‑聚苯丙胺酸两亲性聚合物材料等制成的含硒紫杉醇二聚体前药聚合物纳米给药系统.本发明合成了含硒紫杉醇二聚体前药并将其包封于聚乙二醇‑聚苯丙胺酸两亲性聚合物材料中,通过二聚体的特殊结构,制得高载药聚合物纳米粒,本发明中二聚体前药合成中引入二硒键,能有效提高载体的稳定性,实现药物靶细胞内的可控性释放;本发明中通过多肽分子的修饰,能明显提高纳米粒的乳腺癌靶向性,增加药物的蓄积,从而提高药物的抗肿瘤疗效.

专利信息

专利号:US-2024024489-A1
优先权日:2020-11-20
标 题:Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof
发明人：MULARD LAURENCE; DHARA DEBASHIS; PFISTER HELENE; PAOLETTI JULIE; PHALIPON ARMELLE; GUERREIRO-INVERNO CATHERINE
权利人:PASTEUR INSTITUT
摘要:The present invention provides zwitterionic oligosaccharides, in particular fragments of the surface polysaccharides from Shigella sonnei and Shigella sonnei conjugates comprising them. The present invention also provides protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof, the disaccharide repeating unit of Shigella sonnei being: (I)

专利号:US-9988492-B2
优先权日:2013-09-30
标题:Methods for post-fabrication functionalization of poly(ester ureas)
发明人：BECKER MATTHEW; LIN FEI
权利人:BECKER MATTHEW; LIN FEI; UNIV AKRON
摘要:Amino acid-based poly(ester urea)s (PEU) are emerging as a class of polymers that have shown promise in regenerative medicine applications. Embodiments of the invention relate to the synthesis of PEUs carrying pendent “clickableâ€? groups on modified tyrosine amino acids. The pendent species include alkyne, azide, alkene, tyrosine-phenol, and ketone groups. PEUs with M w exceeding 100k Da were obtained via interfacial polycondensation methods and the concentration of pendent groups was varied by copolymerization. The incorporation of derivatizable functionalities is demonstrated using 1 H NMR and UV-Vis spectroscopy methods. Electrospinning was used to fabricate PEU nanofibers with a diameters ranging from 350 nm to 500 nm. The nanofiber matricies possess mechanical strengths suitable for tissue engineering (Young's modulus: 300±45 MPa; tensile stress: 8.5±1.2 MPa). A series of bioactive peptides and fluorescent molecules were conjugated to the surface of the nanofibers following electrospinning using bio-orthogonal reactions in aquous media.

专利号:US-8372986-B2
优先权日:2005-09-30
标 题 :Ruthenium-catalyzed cycloaddition of alkynes and organic azides
发明人：FOKIN VALERY; JIA GUOCHENG; SHARPLESS K BARRY
权利人:SCRIPPS RESEARCH INST; UNIV HONG KONG SCIENCE & TECHN; FOKIN VALERY; JIA GUOCHENG; SHARPLESS K BARRY
摘要:A convenient process for the regioselective synthesis of 1,5-disubstituted 1,2,3-triazoles and 1,4,5-trisubstituted 1,2,3-triazoles from organic azides and alkynes employs catalytic ruthenium.

专利号:US-12018097-B2
优先权日:2017-06-09
标题 :Non-chromatographic purification of macrocyclic peptides by a resin catch and release
发明人：CREECH GARDNER S; KHEIRABADI MAHBOUBEH; EASTGATE MARTIN D; NIRSCHL DAVID S; CARTER PERCY H
权利人:BRISTOL MYERS SQUIBB CO
摘要:The disclosure is directed to the synthesis and improved methods for purifying macrocyclic peptides produced by solid phase peptide synthesis. The synthesized peptide is capped with an alkyne-functionalized or azide-functionalized compound of formula (I):prior to cleavage of the peptide from the solid phase support.

专利号:WO-2022106703-A1
优先权日:2020-11-20
标 题 :Protected disaccharides, their process of preparation and their use in the synthesis of zwitterionic oligosaccharides, and conjugates thereof

专利号:WO-2012069566-A1
优先权日:2010-11-24
标 题 :Synthesis of n-heterocycles by reductive alkylation of cyan derivatives