专利号:US-2025026768-A1 优先权日:2023-06-30 标题:Method for the synthesis of axially chiral organoboron compounds 发明人:PING YIFAN; CHE CHI-MING 权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD 摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.
专利号:US-7632975-B2 优先权日:2004-12-22 标 题:Process for the synthesis of arylfluorenes and analogs thereof 发明人:HEIDENHAIN SOPHIE 权利人:CDT OXFORD LTD 摘要:A process is provided for the synthesis of a compound of formula (I): n nwherein:n M=0 or 1; N and p are 0 or 1 to 4; X is a single bond, O, S or NH; And R 1 -R 4 are as defined in claim 1.
专利号:US-10570114-B2 优先权日:2016-05-19 标题:Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling 发明人:FISK JASON S; LI XIAOYONG; Muehlfeld Mark; BAUMAN ROBERT S; OPPENHEIMER JOSSIAN; TU SIYU; NITZ MARK A; CHAKRABARTI REETAM; FEIST SHAWN D; RINGER JAMES W; LENG RONALD B 权利人:DOW AGROSCIENCES LLC 摘要:Improved methods of synthesizing 6-aryl-4-aminopicolinates, such as arylalkyl and alkyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates and arylalkyl and alkyl 4-amino-3-chloro-5-fluoro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylates, are described herein. The improved methods include a direct Suzuki coupling step, which eliminates the protection/de-protection steps in the current chemical process, and therefore eliminates or reduces various raw materials, equipment and cycle time as well as modification of other process conditions including use of crude AP, use of ABA-diMe, and varying pH, catalyst concentration, solvent composition, and/or workup procedures. This includes synthesis of 2-aryl-6-aminopyrimidine-4-carboxylates.
专利号:US-2013184465-A1 优先权日:2010-09-30 标 题:Process for the synthesis of thio-triazolo-group containing compounds 发明人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL 权利人:DOCHNAHL MAXIMILIAN; KEIL MICHAEL; GEBHARDT JOACHIM; VOGELBACHER UWE JOSEF; RACK MICHAEL; BASF SE 摘要:The present invention relates to a process using specific magnesium reagents for providing thio-triazolo group-containing compounds and for the synthesis of precursors therefor. The invention furthermore relates to intermediates and to their preparation.
专利号:US-2025188104-A1 优先权日:2023-12-06 标题 :Sequential One-Pot Synthesis of Alkylidyne and Alkylidene Catalysts 发明人:VEIGE ADAM S; BOECK PARK 权利人:THE UNIV OF FLORIDA RESEARCH FOUNDATION INC 摘要:A method of preparing a tetraanionic pincer ligand supported metallacycloalkylene complex in one pot, the method including admixing at low temperature a solution of [ t BuOCO]H 3 and a solution of ( t BuO) 3 W≡CC(CH 3 ) 3 in a second solvent to form a first reaction mixture, warming the first reaction mixture, removing at least a portion of solvent from the first reaction mixture to provide a second reaction mixture, admixing the second reaction mixture and a solvent to form a third reaction mixture, admixing at low temperature the third reaction mixture and a base to form a fourth reaction mixture, warming the fourth reaction mixture to form a fifth reaction mixture; removing at least a portion of the third solvent from the fifth reaction mixture to provide a sixth reaction mixture; washing the sixth reaction mixture with a fifth solvent and removing at least a portion of the fifth solvent to form a seventh reaction mixture; admixing the seventh reaction mixture with a sixth solvent to provide an eighth reaction mixture; cooling the eighth reaction mixture and admixing the eighth reaction mixture with methyl trifluoromethansulfonate to form a ninth reaction mixture; warming the ninth reaction mixture, and admixing a substituted alkyne with the ninth reaction mixture to form the tetraanionic pincer ligand supported metallacycloalkylene complex (1).
专利号:US-2020354404-A1 优先权日:2019-05-09 标 题 :Peptidomimetic agents, synthesis and uses thereof 发明人:AL-ABED YOUSEF 权利人:FEINSTEIN INSTITUTES FOR MEDICAL RESEARCH 摘要:Compounds for use in synthesis of peptidomimetic agents; synthesis of peptidomimetic agents; peptidomimetic diagnostic and therapeutic agents; and uses of the compounds and peptidomimetic agents in drug discovery, diagnosis, prevention and treatment of diseases are described.