CAS: 69409-98-9; 2-Fluoro-4-(Trifluoromethyl)Aniline

该化合物是一种芳烃性矿,其特征是氟原子和附于苯环的三氟甲基组;其分子结构包括一个含有氨基组(-NH2)的苯环,其第二位置是氨基组(-NH2),第四位置是三氟甲基组(-CF3),其独特的化学特性是;该化合物一般无色可粉黄的黄色液体或固体,其纯度和温度取决于其纯度和温度;在有机溶剂中表现出中等溶性,由于三氟甲基组的疏水性,在水中溶性较低;氟原子的存在可增强其化学稳定性,影响其反应性,使其在各种应用中有用,包括制药和农用化学品;此外,该化合物可能展示具体的生物活动,可能对药用化学感兴趣;在处理该物质时应采取安全防范措施,因为如果吸入或浸泡,可能会对健康造成危害.

结构式图片

欧盟法规

ECHA物质C&L通报

上下游产品

CAS号67-56-1 甲醇 | CAS号2339-84-6 2-fluoro-4-(tri... | CAS号88288-14-6 N-(2-fluoro-4-(... | CAS号348-54-9 邻氟苯胺 | CAS号32137-19-2 3,4-二氟三氟甲苯 | CAS号455-14-1 4-氨基三氟甲苯 | CAS号349-97-3 4'-(三氟甲基)乙酰苯胺 | CAS号51632-16-7 间苯氧基溴化苄 | CAS号446-34-4 3-氟-4-硝基甲苯 | CAS号927896-24-0 3-(2-氟-4-(三氟甲基)...

合成工艺路线路线简述

    📜2-氟-4-三氟甲基苯甲酸置于叠氮磷酸二苯酯,三乙胺,Copper(L) Chloride体系中,用 叔丁醇 作为反应溶剂,以58%的收率获得产物2-氟-4-(三氟甲基)苯胺
    参考文献:Processes For The Preparation Of 1-Aryl-5-Alkyl Pyrazole Compounds
    标题:Processes For The Preparation Of 1-Aryl-5-Alkyl Pyrazole Compounds
    摘要:提供了改进的工艺,用于制备式(I)和(Ib)的1-芳基吡唑化合物:这些化合物在吡唑环的5位上用碳链功能基团取代.所述工艺高效可扩展,并且不使用危险的硫基卤代试剂.

    海关参考信息

    专利信息


    专利号:US-4226802-A
    优先权日:1979-10-29
    标题:2-(4-Trifluoromethylphenylamino)-3-methylbutanoic acid esters and intermediates therefor
    发明人:ANDERSON RICHARD J; BAER TED A
    权利人:ZOECON CORP
    摘要:Synthesis of 2-(4-trifluoromethylphenylamino)-3-methylbutanoic acid and lower alkyl esters thereof, optionally ortho substitution on the phenylamino group, novel intermediates thereof, which are useful intermediates in the synthesis of pesticides.

    专利号:US-4517130-A
    优先权日:1982-04-22
    标 题 :Substituted amino acid process
    发明人:BAER TED A
    权利人:ZOECON CORP
    摘要:An improved process for preparing substituted amino acids and lower alkyl esters thereof, and intermediates therefor, comprising reacting a substituted aniline, HCN and an aldehyde to form a nitrile, converting the nitrile to an imidate salt with a strong acid and an alcohol, hydrolyzing in situ the imidate salt to the ester with addition of water, and optionally converting the ester to the salt or free acid. The acids are useful intermediates in the synthesis of pesticides.

    专利号:US-4411912-A
    优先权日:1978-02-16
    标 题 :Insecticidal isovaleric acid esters
    发明人:HENRICK CLIVE A; GARCIA BARBARA A
    权利人:ZOECON CORP
    摘要:Esters and thiolesters of amino acids, intermediates therefor, synthesis thereof, and the use of said esters and thiolesters and compositions for the control of pests.

    专利号:US-2016229847-A1
    优先权日:2013-10-04
    标 题:Novel bicyclic pyridinones as gamma-secretase modulators
    发明人:PETTERSSON MARTIN YOUNGJIN; AM ENDE CHRISTOPHER WILLIAM; GREEN MICHAEL ERIC; JOHNSON DOUGLAS SCOTT; KAUFFMAN GREGORY WAYNE; O'DONNELL CHRISTOPHER WILLIAM; PATEL NANDINI CHATURBHAI; STEPAN ANTONIA FRIEDERIKE; STIFF CORY MICHAEL; SUBRAMANYAM CHAKRAPANI; TRAN TUAN PHONG; VERHOEST PATRICK ROBERT
    权利人:PFIZER
    摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula II as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

    专利号:US-4338318-A
    优先权日:1979-03-23
    标 题 :Novel compositions and methods
    发明人:HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C
    权利人:ZOECON CORP
    摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.

    专利号:US-4297297-A
    优先权日:1979-03-23
    标题 :α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates
    发明人:HENRICK CLIVE A; LABOVITZ JEFFREY N; FOX ROLAND T V; RATHMELL WILLIAM G; SHEPHARD MARGARET C
    权利人:ZOECON CORP
    摘要:Novel 1-substituted uracils, synthesis and intermediates therefor, and compositions for the control of pests.

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