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CAS号93-89-0 苯甲酸乙酯 | CAS号93-58-3 苯甲酸甲酯 | CAS号98-88-4 苯甲酰氯 | CAS号941-02-6 benzoic acid,N,... | CAS号4231-62-3 1-苯甲酰-1H-苯并三唑 | CAS号393-52-2 邻氟苯甲酰氯 | CAS号3080-42-0 N-cyclohexyl-N-... | CAS号18106-71-3 Phosphonic acid... | CAS号65-85-0 苯甲酸 | CAS号59105-30-5 N'-benzoyl-hydr... | CAS号1063-87-2 silicon benzoate | CAS号104662-64-8 铒(III) 离子载体 I | CAS号104642-70-8 N-[4-(3-hydroxy... | CAS号101350-46-3 phenyl-(3-pheny... | CAS号104217-22-3 2-Isopropyl-5-p... | CAS号10465-97-1 Hydrazinecarbox... | CAS号38942-51-7 5-苯基-4-甲基-4氢-3-... | CAS号3393-96-2 4'-硝基苯甲酰苯胺 | CAS号3278-14-6 N-苯乙基-苯甲酰胺 | CAS号49656-91-9 (4,5-二苯基-4H-[1,...

苯甲酸乙酯置于一水合肼体系中,用78%的收率获得产物苯甲酰肼
参考文献:设计和合成2-(取代的芳氧基)-5-(取代的亚苄基)-3-苯基-2,5-二氢-1 H-[1,2,4]三嗪-6-一作为潜在的抗惊厥药
标题:设计和合成2-(取代的芳氧基)-5-(取代的亚苄基)-3-苯基-2,5-二氢-1 H-[1,2,4]三嗪-6-一作为潜在的抗惊厥药
摘要:设计并合成了一系列2-(取代的芳氧基)-5-(取代的亚苄基)-3-苯基-2,5-二氢-1 H-[1,2,4]三嗪-6-一.考虑到药效团的结构要求,并评估其抗惊厥活性和cns活性.腹膜内注射给小鼠后,在最大的电击惊厥(mes)和皮下戊四氮(scptz)诱发的惊厥和神经毒性筛查中检查了一些合成的衍生物.还对那些发现有力的人进行了行为障碍和抑郁活动的评估.在测试的化合物中,两种动物模型中的5 Eix在剂量水平为30 Mg / Kg时均显示出对癫痫发作的保护作用,而5 Bii和5 Cii在相同剂量水平下显示出对scptz模型的保护作用.与临床有效药物相比,某些标题化合物的中枢神经系统抑制作用和神经毒性较小.
DOI:10.1016/j.Ejmech.2010.05.051

专利信息

专利号:US-6127515-A
优先权日:1997-11-18
标 题:Functionalized resin for the synthesis of amides and peptides
发明人：MANFRE FRANCO; VANASSE BENOIT J; LABAUDINIERE RICHARD F; MORTON GEORGE C
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a functionalized amino resin of formula ##STR1## wherein S is a solid support; R is H or alkyl; A is ##STR2## Y is OH or OCOR 1 ; and R 1 is aliphatic or aromatic which is useful for the solid phase synthesis of amides, peptides and hydroxamic acids.

专利号:US-6133409-A
优先权日:1996-12-19
标 题:Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and αβ-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARM PROD INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and alpha , beta -unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-7485718-B2
优先权日:2005-06-16
标题:Chemical synthesis of low molecular weight polyglucosamines and polygalactosamines
发明人：SABESAN SUBRAMANIAM
权利人:DU PONT
摘要:A process for the synthesis of beta linked low molecular weight polymers of galactosamine and glucosamine has been developed. Through the use of high amounts of activating agents, efficient coupling of stable monomers is achieved. Using this process, chain extension is through the addition of single monomers, providing populations of single chain length polyhexosamines.

专利号:US-6710208-B2
优先权日:1996-12-19
标题 :Process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds
发明人：SALVINO JOSEPH M; MORTON GEORGE C; MASON HELEN J; LABAUDINIERE RICHARD F
权利人:AVENTIS PHARMA INC
摘要:This invention is directed to a process for the solid phase synthesis of aldehyde, ketone, oxime, amine, hydroxamic acid and α,β-unsaturated carboxylic acid and aldehyde compounds and to polymeric hydroxylamine resin compounds useful therefor.

专利号:US-2025129021-A1
优先权日:2023-09-19
标 题:Small molecule protein synthesis modulators
发明人：GYGI DAVID; BAHMANYAR SOGOLE SAMI; HAMANN LAWRENCE
权利人:INTERDICT BIO INC
摘要:The present disclosure provides compounds of the formulae herein (e.g., Formula (I), Formula (V)), and pharmaceutically acceptable salts thereof, which are useful for modulating protein synthesis (e.g., modulating synthesis of BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D). The present disclosure also provides pharmaceutical compositions and kits comprising the compounds, or pharmaceutically acceptable salts thereof, and methods of treating or preventing diseases or disorders (e.g., diseases or disorders associated with BCL-2, MYC, CCND1, MCL-1, ALK, KRAS-G12D) by administering to a subject in need thereof the compounds, or pharmaceutically acceptable salts thereof, or pharmaceutical compositions thereof.

专利号:WO-9216499-A1
优先权日:1991-03-13
标 题 :General synthesis method by photochemical process of cyclopropanic components present in natural pyrethrines and in synthetic pyrethroids and their 1-aza-1,4,6 trianic precursors
发明人：ARMESTO VILAS DIEGO; GOMEZ GALLEGO MAR; HORSPOOL WILLIAM M; BERMEJO TORRES FERNANDO
权利人:UNIV MADRID COMPLUTENSE
摘要:The present invention relates to the synthesis of 2,2-dimethyl-3-(vinyl-2,2-bi-substituted) cyclopropanocarboxylic acids. Said acids are present in the majority of natural pyrethrines and in synthetic pyrethroids. These acids are obtained by the transposition reaction aza-di-Ï€-methane of a 1-aza-1,4,6-trianic system for which there are disclosed three different synthetic processes. Thereby, precursors are available to obtain pyrethrines and pyrethroids, obtained by a direct and simple process with a high yield.