CAS: 5598-15-2; Chlorpyrifos-Oxon
- 英文名称Chlorpyrifos-Oxon
- 中文名称氯吡硫磷-氧
- IUPAC名称diethyl (3,5,6-trichloropyridin-2-yl) phosphate
- 其它别名3,5,6-Trichloro-2-Pyridyl Diethyl Phosphate; Chloropyrifos Oxon; Chloropyrifos Oxygen Analog; Chloropyrifosoxon; Chlorpyrifos Oxygen Analogue; 6-Trichloro-2-Pyridyl Diethyl Phosphate; Chlorpyrifos-Ethyl Oxon
- CAS编号5598-15-2
- MFCD编号:MFCD01705571
- EINECS号:690-140-4
- FDA UNII编号:7RC6H1MPX6
- 分子式:C9H11Cl3NO4P分子量:334.52
- 产品CID: 1531984
- 产品分类化学农药原药 → 杀虫剂 → 有机氯杀虫剂
物理性质
MSDS等安全信息
- GHS象形图
- GHS符号GHS06 & GHS09;
注释: Skull and crossbones & Environment - 危险类别急性毒性 类别3(经口)
水生急性毒性 类别1
水生慢性毒性 类别1 - 警示词Danger(危险)
- 危险描述H301 |吞咽会中毒.
H400 |对水生生物毒性极大.
H410 |对水生生物毒性极大并具有长期持续影响. - 防范说明P264-P270-P301+P310-P321-P330-P405-P501
- 危险等级6.1(b)
- UN编号2783
- 危险品标志T+
- 包装等级III
- 安全声明Chlorpyrifos oxon is a cholinesterase or acetylcholinesterase (AChE) inhibitor. A cholinesterase inhibitor (or 'anticholinesterase') suppresses the action of acetylcholinesterase. Because of its essential function, chemicals that interfere with the action of acetylcholinesterase are potent neurotoxins, causing excessive salivation and eye-watering in low doses, followed by muscle spasms and ultimately death. Nerve gases and many substances used in insecticides have been shown to act by binding a serine in the active site of acetylcholine esterase, inhibiting the enzyme completely. Acetylcholine esterase breaks down the neurotransmitter acetylcholine, which is released at nerve and muscle junctions, in order to allow the muscle or organ to relax. The result of acetylcholine esterase inhibition is that acetylcholine builds up and continues to act so that any nerve impulses are continually transmitted and muscle contractions do not stop. Among the most common acetylcholinesterase inhibitors are phosphorus-based compounds, which are designed to bind to the active site of the enzyme. The structural requirements are a phosphorus atom bearing two lipophilic groups, a leaving group (such as a halide or thiocyanate), and a terminal oxygen.
欧盟法规
ECHA物质C&L通报上下游产品
CAS号2921-88-2 毒死蜱 | CAS号6515-38-4 3,5,6-三氯-2-吡啶酚合成工艺路线路线简述
📜毒死蜱置于双氧水体系中,用 溶剂黄146 作为反应溶剂,化学反应 3.0H,以80%的收率获得产物氯吡硫磷一氧
参考文献:Fakhr,I. M. I.; Hegazi,B.; Khatab,M. S.,Egyptian Journal Of Chemistry,1998,Vol. 41,# 1-6,P. 145-154
标题:Fakhr,I. M. I.; Hegazi,B.; Khatab,M. S.,Egyptian Journal Of Chemistry,1998,Vol. 41,# 1-6,P. 145-154
海关参考信息
- 2933310010-吡啶
2919900090-其他磷酸酯
2920299090-其他亚磷酸酯
2901100000-饱和无环烃 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
合成参考文献
参考文献:10.1093/toxsci/kfh163
摘要:Kousba AA, Sultatos LG, Poet TS, Timchalk C. Comparison of chlorpyrifos-oxon and paraoxon acetylcholinesterase inhibition dynamics: potential role of a peripheral binding site. Toxicol Sci. 2004 Aug;80(2):239–48. doi: 10.1093/toxsci/kfh163.
参考文献:10.1007/s00213-006-0426-z
摘要:Laviola G, Adriani W, Gaudino C, Marino R, Keller F. Paradoxical effects of prenatal acetylcholinesterase blockade on neuro-behavioral development and drug-induced stereotypies in reeler mutant mice. Psychopharmacology (Berl). 2006 Aug;187(3):331–44. doi: 10.1007/s00213-006-0426-z.
参考文献:10.1007/s12010-017-2424-5
摘要:Tripathy RK, Aggarwal G, Bajaj P, Kathuria D, Bharatam PV, Pande AH. Towards Understanding the Catalytic Mechanism of Human Paraoxonase 1: Experimental and In Silico Mutagenesis Studies. Applied Biochemistry and Biotechnology. 2017 Feb 04;182(4):1642–62. doi: 10.1007/s12010-017-2424-5.
参考文献:10.1007/s11356-022-19099-w
摘要:Bellas J, Rial D, Valdés J, Vidal-Liñán L, Bertucci JI, Muniategui S, León VM, Campillo JA. Linking biochemical and individual-level effects of chlorpyrifos, triphenyl phosphate, and bisphenol A on sea urchin (Paracentrotus lividus) larvae. Environmental Science and Pollution Research. 2022 Feb 14;29(30):46174–87. doi: 10.1007/s11356-022-19099-w.
参考文献:10.1007/s11626-999-0059-8
摘要:Cao CJ, Mioduszewski RJ, Menking DE, Valdes JJ, Katz EJ, Eldefrawi ME, Eldefrawi AT. Cytotoxicity of organophosphate anticholinesterases. In Vitro Cellular & Developmental Biology - Animal. 1999 Oct;35(9):493–500. doi: 10.1007/s11626-999-0059-8.
📝 需求与反馈
尽可能描述清楚需求与问题信息
