CAS: 480-39-7; (S)-5,7-Dihydroxy-2-Phenylchroman-4-One

上下游产品

benzaldehyde O-acetyl-β-D-glucopyranosyloxy)-phenyl]-ethanone1-[2-hydroxy-4,6-bis-(tetra-O-acetyl-β-D-glucopyranosyloxy)-phenyl]-ethanone 22H18O4C22H18O4 5,7-dihydroxy-2-phenyl-chromen-4-one5,7-dihydroxy-2-phenyl-chromen-4-one 2S-5,7-dihydroxyflavanone diacetate 3,5,7-trihydroxydihydroflavonol 5,7-dihydroxy-8-geranylflavanone

📜2,4,6-三羟基苯乙酮一水合物置于盐酸,Sodium Acetate,N,N-二异丙基乙胺,Potassium Hydroxide体系中,用 甲醇,乙醇,二氯甲烷,水 作为反应溶剂,化学反应 76.0H,反应生成 松属素
参考文献:羽扇豆素及其天然类似物的全合成及抗菌评价
标题:羽扇豆素及其天然类似物的全合成及抗菌评价
摘要:本研究首次通过化学合成获得羽扇豆素 (1) 及其天然类似物 Mundulin (2),Minimiorin (3),Khonklonginol H (4),Flemichin D (5) 和 Eriosemaone A (27) .时间.关键步骤包括电环化以构建线性吡喃环和克莱森/科普重排以安装 8-异戊二烯基取代基.所有化合物均针对临床相关人类病原体进行了体外抗菌活性评估,包括一种革兰氏阴性菌株(大肠杆菌atcc 25922)和四种革兰氏阳性菌株(金黄色葡萄球菌atcc 29213,粪肠球菌atcc 29212,Mrsa21-5 和 Vre Atcc 51299).结果表明,Eriosemaone A (27) 是对抗革兰氏阳性菌最有效的一种,最低抑制浓度在 0.25-0.5 μg/ml 范围内.机理研究表明27对细菌内膜具有非常好的膜靶向能力,可以与细菌膜中
DOI:10.1021/acs.Jnatprod.4C00008

专利信息

专利号:US-2009221568-A1
优先权日:2005-11-04
标题:Synthesis of Inhibitors of FtsZ
发明人：SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
权利人:SHAW JARED; URGAONKAR SAMEER; RAYCHAUDHURI DEBABRATA; LA PIERRE HENRY
摘要:FtsZ, the bacterial analog of tubulin, is a promising new target for developing new antibiotics. It has been shown that polyphenols inhibit the GTPase activity of FtsZ, thereby inhibiting Z-ring formation during mitosis. The present invention provides novel polyphenols compounds, which can be accessed by the synthesis of dichamametin and 2′″-hydroxy-5″-benzylisouvarinol-B as described herein. These novel compounds are useful in treating infections, particularly infections caused by gram-positive organisms. Methods of preparing the inventive compounds are also provided. The compounds are prepared by the benzylation of pinocembrin or chrysin core structure. Pharmaceutical compositions and method of using the compounds to treat disease are also provided. These compounds may be screened for antimicrobial activity as well as other biological activities such as anti-neoplastic, anti-inflammatory, immunosuppressive, and cytotoxic activity.

专利号:WO-2025081225-A1
优先权日:2023-10-17
标 题 :Synthesis of polyphenols
发明人：TURLAND CADE LACHLAN; GROLMAN DAVID; BEHRENDORFF JAMES BRUCE YARNTON HAYCOCK; MORADI SHAYLI VARASTEH; THOMSON RAINE ELIZABETH STURT
权利人:Delica Therapeutics Pty Ltd
摘要:The present disclosure relates to polyphenols, including flavonoids, flavones and cannflavins, and methods of synthesising polyphenols. The present disclosure provides methods, enzymes and compositions that may be useful in the synthesis of polyphenols.

专利号:US-2024026314-A1
优先权日:2020-11-25
标题 :Polypeptides for use in the synthesis of bioactive phenolic compounds
发明人：ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
权利人:ROTHSTEIN STEVEN; AKHTAR TARIQ; CASARETTO JOSE; PERRIN COLBY; VAN GELDER KRISTEN
摘要:Described herein is a polypeptide encoding a prenyltransferase for prenylating a polyphenol and a polypeptide encoding an O-methyltransferase for methylating a polyphenol. For example, the polypeptide comprises or consists of the sequence of SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or a polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a variant thereof having at least 80% sequence identity to SEQ ID NO: 1, 2, 3, 4, 5, and/or 6, and/or the polypeptide listed in Table 1, and/or SEQ ID NO: 7-30, or a fragment of the polypeptide or the variant thereof.

专利号:EP-4251758-A1
优先权日:2020-11-25
标 题:Polypeptides for use in the synthesis of bioactive phenolic compounds

专利号:US-12036300-B2
优先权日:2021-03-31
标题:Methods and compositions for improving skin
发明人：LIAO I-CHIEN; BRIEVA PATRICIA; JUCHAUX FRANCK; BOUEZ CHARBEL; ZHENG QIAN; QIAN KUN
权利人:OREAL
摘要:A method for managing skin tone comprising reducing the synthesis of melanin by applying a skin treatment composition to skin. The skin treatment composition may include about 0.1 to about 25 wt. % of acetyl trifluoromethylphenyl valylglycine; about 0.5 to about 30 wt. % of a polyol; about 0.1 to about 30 wt. % of a silicone, fatty compound, or a mixtures thereof, wherein the skin treatment composition is an emulsion, and all weight percentages are based on the total weight of the skin treatment composition.

专利号:CN-112174924-A
优先权日:2019-07-01
标 题 :Synthesis of deuterated pinocembrin and application of deuterated pinocembrin in preparation of anti-stroke medicine