CAS: 4774-14-5; 2,6-Dichloropyrazine

相似化合物

14508-49-7 19745-07-4 13484-50-9

上下游产品

CAS号2423-84-9 N,N-二氧化吡嗪 | CAS号290-37-9 吡嗪 | CAS号14508-49-7 2-氯吡嗪 | CAS号6863-76-9 3-氯吡嗪1-氧化物 | CAS号7782-50-5 氯气 | CAS号16025-16-4 Pyrazine, 2-chl... | CAS号7732-18-5 水 | CAS号4774-15-6 2,6-二甲氧基吡嗪 | CAS号33332-30-8 2-氯-6-甲氧基哌嗪 | CAS号36070-79-8 6-氯-2-吡嗪羧酰胺 | CAS号312736-49-5 3,5-二氯吡嗪-2-甲酸 | CAS号38557-71-0 2-氯-6-甲基吡嗪 | CAS号33332-28-4 2-氨基-6-氯吡嗪 | CAS号58138-79-7 2,6-二碘吡嗪 | CAS号41270-62-6 2-氯-6-苯基吡嗪 | CAS号426829-52-9 4-(6-氯吡嗪-2-基)哌嗪... | CAS号941294-47-9 2-氯-6-环丙基氨基吡嗪

2-氯吡嗪置于吡啶,氯体系中,化学反应 2.0H,以87.3%的收率获得产物2,6-二氯吡嗪
参考文献:一种2,6-二氯吡嗪的制备方法
标题:一种2,6-二氯吡嗪的制备方法
摘要:本发明公开了一种2,6‑二氯吡嗪的制备方法.该方法包括以下步骤:以甘氨酸,乙二醛等为原料,经氨化和环化反应,制得2‑羟基吡嗪钠;2‑羟基吡嗪钠在n,N‑二异丙基乙胺催化作用下与二氯亚砜反应,制备2‑氯吡嗪;以吡啶作为反应溶剂,2‑氯吡嗪经氯气氯化值得2,6‑二氯吡嗪.该方法的优势是原料甘氨酸价廉易得,且不使用三氯氧磷作为氯代试剂,大大减少了有机含磷废水的产生,为2,6‑二氯吡嗪的高效绿色工业生产提供了有效途径.

专利信息

专利号:US-9663477-B1
优先权日:2014-09-19
标题:Synthesis and structure of 3,5-diamino-2,6-di-(tert-butyl-NNO-azoxy) pyrazine as a critical intermediate in the synthesis of a novel energetic compound
发明人：WILSON REBECCA M; MANNION JOSEPH D; MORAN JESSE S
权利人:WILSON REBECCA M; MANNION JOSEPH D; MORAN JESSE S; US NAVY
摘要:The present disclosure relates generally to a critical intermediate in a synthesis of a postulated energetic material, and more specifically relates to a critical intermediate, 3,5-diamino-2,6-di-(tert-butyl-NNO-azoxy)pyrazine, having the structure: n nThe postulated energetic material has calculated performance properties that greatly exceed those of HMX and CL-20. The specific critical intermediate (Compound 1) shown above has a molecular weight of 310.359 g/mol, a density at −123° C. of 1.293 g/mL, and a density at 20° C. of 1.259 g/mL.

专利号:US-9458115-B2
优先权日:2009-04-20
标 题 :Synthesis of substituted pyrazines
发明人：PAGORIA PHILIP F; ZHANG MAO XI
权利人:PAGORIA PHILIP F; ZHANG MAO XI; L LIVERMORE NAT SECURITY LLC
摘要:A method for synthesizing a pyrazine-containing material according to one embodiment includes contacting an iminodiacetonitrile derivative with a base and a reagent selected from a group consisting of hydroxylamine, a hydroxylamine salt, an aliphatic primary amine, a secondary amine, an aryl-substituted alkylamine a heteroaryl-substituted alkyl amine, an alcohol, an alkanolamine and an aryl alcoholamine. Additional methods and several reaction products are presented.

专利号:US-9549921-B2
优先权日:2013-06-24
标 题:Heterocyclic compounds and methods of use thereof for the treatment of hepatitis C
发明人：HE SHUWEN; LAI ZHONG; DAI XING; XIAO DONG; LONDON CLARE; ZORN NICOLAS; NARGUND RAVI; PALANI ANANDAN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD
权利人:HE SHUWEN; LAI ZHONG; DAI XING; XIAO DONG; LONDON CLARE; ZORN NICOLAS; NARGUND RAVI; PALANI ANANDAN; MCCOMAS CASEY C; LI PENG; PENG XUANJIA; SOLL RICHARD; MERCK SHARP & DOHME
摘要:The present invention relates to compounds of formula I that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.(I)

专利号:EP-3103803-B1
优先权日:2008-10-27
标 题 :Intermediates for the synthesis of mtor kinase inhibitors

专利号:CN-108373416-B
优先权日:2018-04-28
标 题 :A kind of method of photo/nickel synergistic catalysis synthesis of diarylamine

专利号:CN-108794410-A
优先权日:2018-08-30
标题 :Method for one-pot synthesis of 2,6-diaminopyrazine-1-oxide