CAS: 4247-02-3; Isobutyl 4-Hydroxybenzoate

上下游产品

CAS号78-83-1 异丁醇 | CAS号99-96-7 4-羟基苯甲酸 | CAS号24262-66-6 4-乙酰氧基苯甲酸甲酯 | CAS号13031-45-3 ethyl 4-acetylo... | CAS号54835-09-5 benzyl 4-acetox... | CAS号27739-13-5 propyl 4-acetyl...

苯酚置于盐酸,Aluminum (Iii) Chloride,1,8-二氮杂双环[5.4.0]十一碳-7-烯体系中,用 四氢呋喃,氯苯 作为反应溶剂,化学反应 52.0H,反应生成 尼泊金异丁酯
参考文献:使用 Houben-Hoesch 反应从富含同位素的酚中合成 13C 标记的对羟基苯甲酸酯
标题:使用 Houben-Hoesch 反应从富含同位素的酚中合成 13C 标记的对羟基苯甲酸酯
摘要:对羟基苯甲酸酯是多种消费品中的抗菌添加剂.然而,在废水消毒过程中由对羟基苯甲酸酯形成的卤代化合物是一个潜在的环境问题.为了识别这些转化产物并研究它们的形成机制,开发了一种在苯环内特定位置用稳定同位素碳 13 标记对羟基苯甲酸乙酯的合成路线.这种有效的两步法从市售的13 C 标记的苯酚开始,包括 (1) 通过与三氯乙腈的 Houben-Hoesch 反应对苯酚进行初始酰化,然后 (2) 对所得三氯甲基酮进行改进的卤仿反应,得到对应13C 标记的对羟基苯甲酸乙酯的总产率为 65%-80%.还研究了改进的卤仿反应的范围,允许合成衍生自伯醇或仲醇的其他对羟基苯甲酸酯,包括13 C-和氘标记的酯.此外,4-羟基苯甲酸可以直接由常见的三氯甲基酮中间体在用氢氧化锂处理后形成.该方案补充了现有的制备13 C 标记的对羟基苯甲酸酯衍生物的方法,并提供了在 Houben-Hoesch 反应(形成对二取代产物)
DOI:10.1002/jlcr.3992

专利信息

专利号:US-10768157-B2
优先权日:2015-10-20
标 题:Materials and methods for the detection of trace amounts of substances in biological and environmental samples
发明人：KABIR ABUZAR; FURTON KENNETH G
权利人:KABIR ABUZAR; FURTON KENNETH G; THE FLORIDA INTERNATIONAL UNIV BOARD OF TRUSTEES
摘要:The subject invention provides chemical compositions and synthesis strategies to create molecularly imprinted polymers (MIPs) via sol-gel processes. In a specific embodiment, the subject invention utilizes a(n) organic, inorganic, or metallic template analyte to create a hybrid organic-inorganic or inorganic three-dimensional network possessing cavities complementary to the shape, size, and functional orientation of the template molecule or ions. The subject invention further pertains to the use of the novel MIPs as selective solid phase extraction (SPE) sorbents for pre-concentration and clean-up of trace substances in biological and environmental samples. Synthesis of other molecularly imprinted polymers with environmental, pharmaceutical, chemical, clinical, toxicological, and national security implications can be conducted in accordance with the teachings of the subject invention.

专利号:US-8450456-B2
优先权日:2007-12-21
标题:Activating peptide of the synthesis of aquaporins and cosmetic and/or pharmaceutical composition containing it
发明人：DAL FARRA CLAUDE; DOMLOGE NOUHA; BOTTO JEAN-MARIE
权利人:DAL FARRA CLAUDE; DOMLOGE NOUHA; BOTTO JEAN-MARIE; ISP INVESTMENTS INC
摘要:The present invention concerns a peptide of the general formula (I): n R 1 -(AA) n -X 1 —X 2 —X 3 -Pro-X 4 —X 5 —X 7 -(AA) p -R 2 , capable of activating the synthesis of proteins of the family of aquaporins. n The present invention also concerns a cosmetic, nutraceutical or pharmaceutical composition, comprising a peptide of general formula (I) as active principle. The invention also relates to the use of this new active principle in a cosmetic or nutraceutical composition, intended to improve the moisturizing and the barrier function of the epidermis and intended to stimulate cutaneous regeneration. The invention also relates to the use of this new active principle to realize a pharmaceutical composition, and in particular a dermatological composition, intended to regulate and/or stimulate the activity of the aquaporins and to thus treat the pathological dryness of the skin or mucosa. The invention also relates to a method of cosmetic treatment intended to prevent or combat against dryness of the skin and mucosa, and the manifestations of cutaneous ageing.

专利号:US-9579267-B2
优先权日:2011-07-14
标 题:Cosmetic with enhanced collagen I synthesis
发明人：DOUCET OLIVIER; BERNINI DOROTHEE; ROBERT CECILE; PUJOS MURIEL
权利人:DOUCET OLIVIER; BERNINI DOROTHEE; ROBERT CECILE; PUJOS MURIEL; COTY GERMANY GMBH
摘要:A cosmetic including two different systems for procurement of actives in the human skin and enhancing the collagen I synthesis. The cosmetic with enhanced collagen I synthesis can include 0.001 to 2% by weight, related to the total weight of the cosmetic, of a first retinol-containing system including retinol encapsulated in a chitosan and carboxymethyl cellulose shell, 0.001 to 3.5% by weight, related to the total weight of the cosmetic, of a second retinol-containing system including cationic liposomes composed of phospholipids and with a quaternary fatty acid monoamine with C 21 -C 23 alkyl residue and the difference to 100% by weight of cosmetic subsidiaries. Very small amounts of retinol in combination with both transport systems show a remarkable effect on the synthesis of collagen I in comparison with one or more other known combinations of retinol derivatives or encapsulated systems.

专利号:US-2012094919-A1
优先权日:2009-03-16
标题 :Use of tripeptides
发明人：GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
权利人:GRAEUB REMO; HEIDL MARC; IMFELD DOMINIK; MUELLER EIKE; WIKSTROEM PETER; ZIEGLER HUGO
摘要:The present invention relates to the use of tripeptide derivatives for tightening, firming and/or moisturizing skin. Furthermore, the invention relates to a method for stimulating the synthesis of glycosaminoglycans containing a D-glucosamine and/or N-acetyl-D-glucosamine residue and/or proteoglycans by fibroblasts and/or keratinocytes such as in particular the synthesis of Hyaluronic acid and/or of the proteoglycans Decorin and/or Lumican.

专利号:US-7842670-B2
优先权日:2005-04-01
标题:Cosmetic and pharmaceutical compounds for inducing the synthesis of SIRT proteins in skin and methods of use thereof
发明人：DAL FARRA CLAUDE; DOMLOGE NOUHA; BOTTO JEAN-MARIE
权利人:ISP INVESTMENTS INC
摘要:A cosmetic dermo-pharmaceutical, or dermatological composition having as an active agent in an acceptable cosmetic or pharmaceutical medium, at least one compound able to activate the synthesis or SIRT proteins in skin cells.

专利号:US-2025268860-A1
优先权日:2021-10-22
标 题 :Composition for use in the cutaneous synthesis of hyaluronic acid, in an immuno-cutaneous response and to improve skin
发明人：BERNARD PHILIPPE
权利人:JR
摘要:A composition comprising baicalin or a derivative thereof, more particularly in combination with chlorogenic acid or a derivative thereof, as well as the cosmetic use of such a composition and its medical applications.