CAS: 40856-44-8; (S)-3-Amino-3-Phenylpropionic Acid

上下游产品

N-(R)-α-Methylbenzyl-(S)-3-phenylisoxazolidin-5-one N-(phenylacetyl)-3-amino-3-phenylpropanoic acid tert-butyl (R)-3-amino-3-phenylpropionate 4-phenylazetidin-2-one (R)-3-dimethylamino-3-phenylpropionic acid (R)-3-benzamido-3-phenylpropanoic acid (R)-3-[4-((R)-2-Carboxy-1-phenyl-ethylcarbamoyl)-pyridine-2-sulfonylamino]-3-phenyl-propionic acid (R)-3-benzamido-3-phenylpropanoic acid methyl ester

(3S)-3-氨基-3-苯基丙酸叔丁酯置于三氟乙酸体系中,用 二氯甲烷 作为反应溶剂,化学反应 15.0H,以96%的收率获得产物(S)-3-氨基-3-苯基丙酸
参考文献:平行合成手性β-氨基酸
标题:平行合成手性β-氨基酸
摘要:使用高手性锂n-苄基-N-(α-甲基苄基)酰胺的共轭加成,完成了对映体纯度高的30个β-氨基酸阵列的平行不对称合成.该协议的实验简单性和高度实用性通过高15种α,β-不饱和酯的高效平行转化为相应β-氨基酸的对映体系列以高总收率和选择性进行了证明,且每个步骤的纯化步骤最少反应方案.
DOI:10.1016/j.Tetasy.2007.06.008

专利信息

专利号:US-2023037284-A9
优先权日:2018-11-30
标题:Combination therapy of peptidomimetic macrocycles
发明人：GUERLAVAIS VINCENT; ANNIS DAVID ALLEN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2025084410-A1
优先权日:2015-01-12
标 题:Incorporation of unnatural nucleotides and methods thereof
发明人：PTACIN JEROD; MALYSHEV DENIS A; CAFFARO CAROLINA E
权利人:SYNTHORX INC
摘要:Disclosed herein are methods, compositions and kits for the synthesis of proteins which comprises unnatural amino acids that utilize a mutant tRNA.

专利号:US-8084641-B2
优先权日:2005-10-11
标 题:Organocataslysts and methods of use in chemical synthesis
发明人：WANG WEI
权利人:WANG WEI; STC UNM
摘要:The present invention is directed to compositions comprising organocatalysts that facilitate stereo-selective reactions and the method of their synthesis and use. Particularly, the invention relates to metal-free organocatalysts for facilitation of stereo-selective reactions, and the method of their synthesis and use.

专利号:US-2018371021-A1
优先权日:2017-05-11
标 题 :Peptidomimetic macrocycles and uses thereof
发明人：AIVADO MANUEL; GUERLAVAIS VINCENT; OLSON KAREN
权利人:AILERON THERAPEUTICS INC
摘要:The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.

专利号:US-2005009151-A1
优先权日:2003-07-10
标 题 :Methods for the stereospecific and enantiomeric enrichment of beta-amino acids
发明人：CHASE MATTHEW; CLAYTON ROBERT; LANDIS BRYAN; BANERJEE AMIT
权利人:PHARMACIA CORP
摘要:The present invention relates to methods for the stereospecific synthesis and for the enantiomeric enrichment of β-amino acids. A novel D-β-aminotransferase, which exhibits stereoselectivity for D-β-phenylalanine, (D-3 amino-3-phenylpropinine acid) was purified from a newly-isolated strain of Variouorax paradoxus . A novel L-β-aminotransferase was purified from a newly-isolated strain of Alcaligenes eutrophus . The D- and L-β-aminotransferases can be used to facilitate the stereoselective biosynthesis of β-D-phenylalanine or β-L-phenylalanine, from a mixture of L-glutamic acid or L-alanine, respectively, and 3-keto-3-phenylpropionic acid in the presence of the cofactor pyridoxal phosphate.

专利号:CN-107501112-B
优先权日:2017-09-15
标 题:A kind of Chiral Synthesis of chiral beta-amino acids and the synthetic method of medicine intermediate