CAS: 33538-09-9; 2-(Tert-Butyl)Isonicotinonitrile

该化合物是一种专门的有机化合物,其特点是在2位置用三丁基锡化合物替换一个核核心,在4位置上则用三丁基锡化合物组替换一个三丁基锡化合物,这种结构具有独特的消毒和电子特性,使其作为制药和农用化学合成的中间体具有价值.三丁基锡化合物组增强了稳定性和影响反应性,而硝基苯的功能为进一步衍生提供了多种用途.其定义明确的分子结构确保了在诸如离子体设计和三环化学等应用中保持一贯性能.该化合物的特点是在标准处理条件下具有高度纯性和稳定性,适合研究和工业规模的工艺.

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合成工艺路线路线简述

    📜2-Tert-Butyl-Isonicotinic Acid Amide置于三氯氧磷体系中,化学反应生成2-叔丁基-4-氰基吡啶
    参考文献:Libermann Et Al.,Bulletin De La Societe Chimique De France,1958,P. 687,691
    标题:Libermann Et Al.,Bulletin De La Societe Chimique De France,1958,P. 687,691

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    专利信息


    专利号:US-4469701-A
    优先权日:1983-06-23
    标题 :Pyrrolid-3-en-2-ones and pharmaceutical methods of use thereof
    发明人：DEBAUN JACK R; PALLOS FERENC M; MATSUMOTO KENT E; ROSS JOHN H
    权利人:STAUFFER CHEMICAL CO
    摘要:Novel compounds having the structural formula ##STR1## wherein R 1 and R 2 are independently selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, thioalkyl, thiohaloalkyl, alkoxy, cyano and nitro are provided. The compounds have various pharmacological effects, including cardiotropic, hypoglycemic, hypocholesterolemic and/or antiulcerative effects in mammals. Methods of achieving these various pharmacological effects in mammals by administering the compounds thereto are provided. Pharmaceutical compositions and formulations including the compounds are provided along with methods of synthesis of the novel compounds.

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    主要参考文献

    参考标题:Synthesis Of Sterically Hindered Primary Amines By Concurrent Tandem Photoredox Catalysis
    作者:Michael C. Nicastri,Dan Lehnherr,Yu-Hong Lam,Daniel A. Dirocco,Tomislav Rovis |发布日期:2020.1.15
    摘要:Methodologies Exist For Amine Synthesis, But The Direct Synthesis Of Primary Amines With A Fully Substituted α Carbon Center Is An Underdeveloped Area. We Report A Method Which Utilizes Photoredox Catalysis To Couple Readily Available O-Benzoyl Oximes With Cyanoarenes To Synthesize Primary Amines With Fully Substituted α-Carbons. We Also Demonstrate That This Method Enables The Synthesis Of Amines With α-Trifluoromethyl

    合成参考文献

    参考DOI号:10.1021/acs.j°C.9b00366
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