CAS: 333359-90-3; (1S)-1,5-Anhydro-1-C-[4-Chloro-3-[(4-Methoxyphenyl)Methyl]Phenyl]-D-Glucitol

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    上下游产品

    (2S, 3R, 4S, 5S, 6R)-2-(3-(4-methoxybenzyl)-4-chlorophenyl)-tetrahydro-6-(hydroxymethyl)-2-methoxy-2H-pyran-3,4,5-triol [4-(5-bromo-2-chloro-benzyl)-phenoxy]-tert-butyl-dimethyl-silane (2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)-2-methoxytetrahydro-2H-pyran-3,4,5-triol (2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-hydroxybenzyl)phenyl)-6-(hydroxymethyl)tetrahydro-2H-pyran-3,4,5-triol 1-chloro-2-(4-methoxy-benzyl)-4-[2,3-O-(2,3-dimethoxy-buta-2,3-diyl)-β-D-glucopyranos-1-yl]-benzene

    合成工艺路线路线简述

      📜(2S,3R,4S,5S,6R)-2-(4-Chloro-3-(4-Methoxybenzyl)Phenyl)-6-(Hydroxymethyl)-2-Methoxytetrahydro-2H-Pyran-3,4,5-Triol置于三乙基硅烷,三氟化硼乙醚体系中,用 二氯甲烷,乙腈 用作溶剂,化学反应生成(2S,3R,4R,5S,6R)-2-(4-氯-3-(4-甲氧基苄基)苯基)-6-(羟甲基)四氢-2
      参考文献: Processes For The Preparation Of Sglt2 Inhibitors[fr] Procédés De Préparation D'Inhibiteurs De Sglt2
      标题: Processes For The Preparation Of Sglt2 Inhibitors[fr] Procédés De Préparation D'Inhibiteurs De Sglt2

      海关参考信息

      专利信息


      专利号:US-8791077-B2
      优先权日:2008-05-22
      标 题:Method for treating hyperuricemia employing an SGLT2 inhibitor and composition containing same
      发明人:LESLIE BRUCE ROBERT
      权利人:LESLIE BRUCE ROBERT; ASTRAZENECA AB
      摘要:Methods are provided for treating hyperuricemia, employing an SGLT2 inhibitor alone, or in combination with a supply of carbohydrate, and/or in combination with an inhibitor of uric acid synthesis. Additionally, pharmaceutical compositions comprising an SGLT2 inhibitor with a supply of carbohydrate or an inhibitor of uric acid synthesis or a supply of carbohydrate and an inhibitor of uric acid synthesis are provided in the instant invention and are provided for use in the inventive methods.

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      📌 第三方产品分析报告

      ✅ COA系统入驻 | 共享模式

      合成参考文献


      参考文献:10.1016/j.bmcl.2010.01.075
      摘要:Robinson RP, Mascitti V, Boustany-Kari CM, Carr CL, Foley PM, Kimoto E, Leininger MT, Lowe A, Klenotic MK, MacDonald JI, Maguire RJ, Masterson VM, Maurer TS, Miao Z, Patel JD, Préville C, Reese MR, She L, Steppan CM, Thuma BA, Zhu T. C-Aryl glycoside inhibitors of SGLT2: Exploration of sugar modifications including C-5 spirocyclization. Bioorganic & Medicinal Chemistry Letters. 2010 Mar;20(5):1569–72. doi: 10.1016/j.bmcl.2010.01.075.
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