CAS: 3289-53-0; 6-Methoxy-2-(Methylthio)Pyrimidin-4-Amine

相似化合物

1004-40-6 696-45-7 90905-46-7

上下游产品

6-Amino-2-thiouracil dimethyl sulfate sodium methylate methyl iodide 4-amino-6-methoxypyrimidine 6-methoxypyrimidin-4(3H)-one Hg2(4-amino-6-methoxy-2-methylthiopyrimidine)2(μ-Cl)2Cl2

📜Sodium Methylate,4-氨基-6-氯-2-甲硫基嘧啶 以 甲醇 作为反应溶剂,化学反应 72.0H,以91%的收率获得产物6-氨基-4-甲氧基-2-甲基硫脲嘧啶
参考文献:5-亚硝基嘧啶中的可调推挽相互作用
标题:5-亚硝基嘧啶中的可调推挽相互作用
摘要:探索了一系列不同取代的5-亚硝基嘧啶中推拉相互作用对分子内氢键强度,形式单键周围旋转势垒高度,Uv-Vis光谱和电化学行为的影响.分子内电荷转移(ict)导致电子密度从供电子取代基转移,这很容易通过NMR光谱观测到.5-亚硝基能够与相邻的氨基取代基形成牢固的分子内氢键.结果,对于在相邻位置具有两个不同氢键供体的化合物,观测到了具有5-亚硝基反向取向的两个旋转异构体.信息通讯技术极大地影响了两个漫游者之间相互转换的障碍,而这种旋转异构体的比例主要取决于氢键供体的特性.ict还会显着影响uv-Vis吸收最大值的位置,可以通过选择合适的取代基在100 Nm的宽范围内进行调整.最后,Ict影响5-亚硝基嘧啶的氧化电位和所得亚硝基自由基阳离子的稳定性,其结构由epr光谱法确定.
DOI:10.1021/acs.Joc.6B00446

专利信息

专利号:US-2017275287-A1
优先权日:2014-08-22
标 题 :Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof
发明人：LIPFORD GRAYSON B; ZEPP CHARLES M
权利人:JANUS BIOTHERAPEUTICS INC
摘要:Compounds as immune system modulators bearing a pteridine core are described. A pharmaceutical composition comprising the same, methods of making the same, and a method for treating or preventing autoimmunity disease using the same are described.

专利号:US-5612468-A
优先权日:1994-05-18
标题:Pteridine nucletide analogs as fluorescent DNA probes
发明人：HAWKINS MARY E; PFLEIDERER WOLFGANG; DAVIS MICHAEL D; BALIS FRANK
权利人:US HEALTH
摘要:The invention provides novel pteridine nucleotides which are highly fluorescent under physiological conditions and which may be used in the chemical synthesis of fluorescent oligonucleotides. The invention further provides for fluorescent oligonucleotides comprising one or more pteridine nucleotides. In addition the invention provides for pteridine nucleotide triphosphates which may be used as the constituent monomers in DNA amplification procedures.

专利号:EP-3183251-A1
优先权日:2014-08-22
标题 :Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof

专利号:EP-3398948-A2
优先权日:2014-08-22
标题 :2,4,6,7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof

专利号:WO-2016029077-A1
优先权日:2014-08-22
标题:Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof