CAS: 2971-90-6; 3,5-Dichloro-2,6-Dimethylpyridin-4-Ol

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1196157-19-3 1227499-23-1 1823899-02-0

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CAS号137812-99-8 3,5-dichloro-4-...

乙酰乙酸乙酯置于ammonium Hydroxide,氯体系中,化学反应 9.0H,以91.5%的收率获得氯羟吡啶
参考文献:一种2,6-二甲基-3,5-二氯-4-羟基吡啶的制 备方法
标题:一种2,6-二甲基-3,5-二氯-4-羟基吡啶的制 备方法
摘要:本发明公开了一种2,6‑二甲基‑3,5‑二氯‑4‑羟基吡啶的制备方法,所述方法以乙酰乙酸乙酯为原料,以弱碱性离子交换树脂为催化剂,在25~90oc条件下进行二聚反应,反应结束后,加入水并通入氨气在10~45oc进行氨化,再通入氯气在10~45oc进行氯化,反应液后处理,获得2,6‑二甲基‑3,5‑二氯‑4‑羟基吡啶;本发明以弱碱性离子交换树脂为催化剂,以乙酰乙酸乙酯为原料,采用串联技术制备目标产品,简化了单元反应,生产过程中易操作和后处理,反应结束后,只需对反应液进行过滤,滤饼回收催化剂,滤液重结晶就可以获得产物,产率达91.5%,产物分离纯化简单,无污染,是一种绿色制备方法.

专利信息

专利号:CN-113817045-B
优先权日:2021-11-23
标 题 :Synthesis of artificial antigen with clopidol and its application in colloidal gold kit

专利号:RU-2072990-C1
优先权日:1992-03-31
标 题:Method of synthesis of 2,6-dimethyl-3,5-dichloro-4(1h)-pyridone

专利号:CN-207546526-U
优先权日:2017-12-01
标题 :A kind of stirring decoloration device for clopidol synthesis

专利号:US-9249103-B2
优先权日:2012-01-13
标题:Compounds, compositions and associated methods comprising 3-aryl quinolines
发明人：RISCOE MICHAEL K; WINTER ROLF W; POU SOVITJ; HINRICHS DAVID J; KELLY JANE XU; LI YUEXIN; NILSEN AARON
权利人:UNIV OREGON HEALTH & SCIENCE; US DEPT VETERANS AFFAIRS
摘要:Compounds, compositions and methods useful for treating infectious diseases are provided. In particular, 3-aryl quinoline compounds, their synthesis, pharmaceutical compositions thereof and methods of treating infectious diseases such as malaria, are disclosed.