CAS: 2525-02-2; 4-Propylbenzene-1,2-Diol

上下游产品

dihydrosafrole 4-allylguaiacol 2,2-dichloro-5-propyl-benzo[1,3]dioxole ethanol 4-propyl-1,2-phenyl diacetate dihydrosafrole 4-allyl-5-propylbenzene-1,2-diol 3-allyl-4-propylbenzene-1,2-diol

📜丁香酚置于aluminium(III) Iodide体系中,用 正己烷 用作溶剂,化学反应 18.0H,以62%的收率获得4-丙基苯-1,2-二醇
参考文献:吡啶改善了三碘化铝诱导的烷基邻羟基苯基醚的选择性裂解:一种通过丁香酚去甲基化制备羟基茶维醇的实用且有效的方法
标题:吡啶改善了三碘化铝诱导的烷基邻羟基苯基醚的选择性裂解:一种通过丁香酚去甲基化制备羟基茶维醇的实用且有效的方法
摘要:丁香酚与三碘化铝的去甲基化由于意外的氢化副反应而变得复杂.氢化通过级联去质子化,氢碘化和氢卤交换过程进行,并且可以通过提前抑制氢碘化来防止.因此开发了一种实用的去甲基化程序,通过使用吡啶作为添加剂以基本定量的收率提供羟基茶维醇.该方法对裂解烷基邻羟基苯基醚具有选择性,并且与多种官能团相容.
Doi:10.1055/s-0035-1588889

专利信息

专利号:US-6252092-B1
优先权日:1999-04-30
标 题 :Process for synthesis of 5-alkylbenzodioxoles
发明人：BORZATTA VALERIO; BRANCALEONI DARIO; BATTISTINI CHRISTIAN
权利人:ENDURA SPA
摘要:The following description refers to a new process for the synthesis of 5-alkylated benzo[1,3]dioxole, comprising the following steps in sequence: catalytic hydrogenation of 4-acylphenol; acylation; displacement catalysed by Lewis acids; treatment with an inorganic basic compound and hydrogen peroxide; reaction with alkyl dihalides or dialkoxyalkanes. n The process described herein, which yields 5-alkylbenzo[1,3]dioxoles, is economic and can be easily scaled up to industrial size.

专利号:US-11746364-B2
优先权日:2018-01-17
标题 :Enzymatic synthesis of kavalactones and flavokavains
发明人：PLUSKAL TOMÃ?S; Weng jing-ke
权利人:WHITEHEAD INST BIOMEDICAL RES
摘要:Disclosed are methods, compositions, proteins, nucleic acids, cells, vectors, compounds, reagents, and systems for the preparation of kavalactones, flavokavains, and kavalactone and flavokavain biosynthetic intermediates using enzymes expressed in heterologous host cells, such as microorganisms or plants, or using in vitro enzymatic reactions. This invention also provides for the expression of the enzymes by recombinant cell lines and vectors. Furthermore, the enzymes can be components of constructs such as fusion proteins. The kavalactones produced can be utilized to treat anxiety disorder, insomnia, and other psychological and neurological disorders. The flavokavains produced can be utilized to treat various cancers including colon, bladder, and breast cancers.

专利号:WO-2013001830-A1
优先权日:2011-06-30
标题 :Nucleoside antibiotic derivative
发明人：ICHIKAWA SATOSHI; MATSUDA AKIRA; OKAMOTO KAZUYA; SAKAGAMI MASAHIRO
权利人:UNIV HOKKAIDO NAT UNIV CORP; SHIONOGI & CO; ICHIKAWA SATOSHI; MATSUDA AKIRA; OKAMOTO KAZUYA; SAKAGAMI MASAHIRO
摘要:The present invention addresses the problem of providing a new compound having antibacterial activity. Disclosed is a compound expressing antibacterial activity, more preferably an antibacterial nucleoside compound expressing antibacterial activity by inhibiting the activity of MraY, particularly a new derivative of Pacidamycin that is an MraY inhibitor. This new derivative of Pacidamycin or a pharmaceutically acceptable salt therof solve the abovementioned problem. By means of the method of the present invention, total synthesis of natural Pacidamycin D and its derivative is achieved.

专利号:WO-2012032085-A1
优先权日:2010-09-10
标题 :Synthesis of trivalent flexible frameworks with ligands comprising catechol units for functionalizing surfaces

专利号:CN-111254151-A
优先权日:2020-04-01
标 题 :A catechol 1,2-dioxygenase gene and its application in the synthesis of 4-position substituted cis, cis-muconic acid

专利号:WO-2012032084-A1
优先权日:2010-09-10
标 题:Synthesis of tripodal catechol derivatives having an adamantyl basic framework for functionalizing surfaces