CAS: 24003-67-6; 2-Hexanamidoacetic Acid

该化合物是甘油和六氟酸的氨化衍生物,其特征是结构,其结构特征是附于氨基酸甘油的六氟基(六碳脂肪酸链),该化合物一般是白色的,非白色固体的,在水和有机溶剂中可溶解,反映了其非非物理性质,因为它含有盐酸(甘油)和缺水(丙醇)成分.Hexounicalcine对各种应用都感兴趣,包括它可能用作表面活性剂,乳油剂,或因其皮肤调节特性而在化妆剂中的潜在用途.此外,该化合物还可能展示生物活动,成为药理学和生物化学研究的课题.其稳定性和再活性可能受到诸如pH和温度等环境因素的影响,而这些环境因素是其实际应用中的重要考虑因素.

结构式图片

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2441-41-0 14305-32-9 14246-53-8

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CAS号50-00-0 甲醛 | CAS号628-02-4 己酰胺 | CAS号201230-82-2 carbon monoxide | CAS号142-61-0 己酰氯 | CAS号56-40-6 甘氨酸 | CAS号142-62-1 正己酸 | CAS号2051-49-2 正已酸酐 | CAS号62005-22-5 N-hexanoyl-glyc... | CAS号881-90-3 2-甲基-4-(苯基亚甲基)噁... | CAS号31295-09-7 Glycine,N-(1-ox...

合成工艺路线路线简述

  • 合成目标产物 2-Hexanamidoacetic Acid 主要起始原料 Glycine And Hexanoic Acid
  • (文献来源)合成步骤主要原料 Glycine 和 Hexanoic Acid
📜己酸置于sodium Hydroxide,三氯化磷体系中,用 水,丙酮 用作溶剂,化学反应 5.0H,反应生成己酰甘氨酸
参考文献:基于甘氨酸和丝氨酸的氨基酸表面活性剂的结构与性质的关系
标题:基于甘氨酸和丝氨酸的氨基酸表面活性剂的结构与性质的关系
摘要:用丙酸,辛酸,癸酸,十二烷酸,十四烷酸和十六烷酸合成了两种基于甘氨酸和丝氨酸的表面活性剂.用ms和1 H NMR对所有表面活性剂进行了表征,合成的表面活性剂的结构正确,可解释ms和1 H NMR中的信号.研究了反应条件,表面性质和泡沫性质.对于两个系列表面活性剂,临界胶束浓度(cmc)和γ Cmc(cmc处的表面张力)随着碳链长度的增加而降低,表面活性增强.具有十四烷酰基和十六烷酰基的表面活性剂显示出非常好的发泡性能,尤其是长链酰基丝氨酸的性能更好.这些都与丝氨酸中的氢甲基有关.
Doi:10.1007/s11743-012-1432-2

海关参考信息

专利信息


专利号:US-6355416-B1
优先权日:1997-02-14
标 题:Assay for the measurement of DNA synthesis rates
发明人：ABRAMSON FRED P
权利人:UNIV GEORGE WASHINGTON
摘要:Use of nonradioactive tracer technology used to measure DNA synthesis rates. DNA synthesis is determined by administering one or more stable isotope labelled precursors to one or more of DNA molecules and the amount of the stable isotope label in the DNA that is extracted from cells that are of interest is measured.

专利号:US-8933207-B2
优先权日:2010-07-28
标 题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C
权利人:CHEN ZHIYU; LANCASTER THOMAS M; ZION TODD C; SMARTCELLS INC
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: I wherein each of X, Alk 1 , Alk 2 , and W are as defined and described herein.

专利号:GB-584918-A
优先权日:1943-11-23
标 题:Improvements in and relating to the synthesis of thiazolidine compounds

专利号:US-2013131310-A1
优先权日:2010-07-28
标题 :Drug-ligand conjugates, synthesis thereof, and intermediates thereto
发明人：KANE JOHN; LANCASTER THOMAS M; ZION TODD C
权利人:KANE JOHN; LANCASTER THOMAS M; ZION TODD C
摘要:The present invention relates to methods for synthesizing compounds of formula I or pharmaceutically acceptable salts thereof: (I) wherein each of X, Alk, and W are as defined and described herein.

专利号:CN-117003667-B
优先权日:2023-07-05
标题:Design, synthesis and application of a class of N-alkanoylglycine homologues that can be used in retention index system

专利号:CN-117003667-A
优先权日:2023-07-05
标题:Design, synthesis and application of a class of N-alkanoylglycine homologues that can be used in retention index systems

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主要参考文献

[参考文献]: Lee N, Et Al. Endogenous Toxic Metabolites And Implications In Cancer Therapy. Oncogene. 2020 Aug;39(35):5709-5720.
[参考文献]: Nowaczyk Mj, Et Al. Ethylmalonic And Methylsuccinic Aciduria In Ethylmalonic Encephalopathy Arise From Abnormal Isoleucine Metabolism. Metabolism. 1998 Jul;47(7):836-9.

合成参考文献


参考文献:10.1023/a:1005504223140
摘要:Wanders RJ, Vreken P, den Boer ME, Wijburg FA, van Gennip AH, IJlst L. Disorders of mitochondrial fatty acyl-CoA beta-oxidation. J Inherit Metab Dis. 1999 Jun;22(4):442–87. doi: 10.1023/a:1005504223140.
参考文献:10.1038/s41467-021-24482-1
摘要:Wu P, Chen D, Ding W, Wu P, Hou H, Bai Y, Zhou Y, Li K, Xiang S, Liu P, Ju J, Guo E, Liu J, Yang B, Fan J, He L, Sun Z, Feng L, Wang J, Wu T, Wang H, Cheng J, Xing H, Meng Y, Li Y, Zhang Y, Luo H, Xie G, Lan X, Tao Y, Li J, Yuan H, Huang K, Sun W, Qian X, Li Z, Huang M, Ding P, Wang H, Qiu J, Wang F, Wang S, Zhu J, Ding X, Chai C, Liang L, Wang X, Luo L, Sun Y, Yang Y, Zhuang Z, Li T, Tian L, Zhang S, Zhu L, Chang A, Chen L, Wu Y, Ma X, Chen F, Ren Y, Xu X, Liu S, Wang J, Yang H, Wang L, Sun C, Ma D, Jin X, Chen G. The trans-omics landscape of COVID-19. Nature Communications. 2021 Jul 27;12(1):4543. doi: 10.1038/s41467-021-24482-1.
参考文献:10.1023/b:boli.0000037343.90450.8d
摘要:Napolitano N, Wiley V, Pitt JJ. Pseudo-glutarylcarnitinaemia in medium-chain acyl-CoA dehydrogenase deficiency detected by tandem mass spectrometry newborn screening. J Inherit Metab Dis. 2004;27(4):465–71. doi: 10.1023/b:boli.0000037343.90450.8d.
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