CAS: 219766-25-3; N-(2-((2-Oxoazepan-3-yl)Carbamoyl)Phenyl)Benzo[b]Thiophene-2-Carboxamide

主要参考文献

1: Tillu DV, Hassler SN, Burgos-Vega CC, Quinn TL, Sorge RE, Dussor G, Boitano S, Vagner J, Price TJ. Protease activated receptor 2 (PAR2) activation is sufficient to induce the transition to a chronic pain state. Pain. 2015 Feb 12. [Epub ahead of print] doi: 10.1371/journal.ppat.1004681. eCollection 2015 Feb.
3: Zhang JC, Wu J, Fujita Y, Yao W, Ren Q, Yang C, Li SX, Shirayama Y, Hashimoto K. Antidepressant Effects of TrkB Ligands on Depression-Like Behavior and Dendritic Changes in Mice After Inflammation. Int J Neuropsychopharmacol. 2014 Oct 31;18(4). pii: pyu077. doi: 10.1093/ijnp/pyu077. doi: 10.1536/ihj.14-168. Epub 2014 Dec 11. doi: 10.1111/cns.12343. Epub 2014 Nov 27. doi: 10.1186/1744-8069-10-59.
8: Chen W, Walwyn W, Ennes HS, Kim H, McRoberts JA, Marvizón JC. BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals. Eur J Neurosci. 2014 May;39(9):1439-54. doi: 10.1111/ejn.12516. Epub 2014 Mar 11.

合成参考文献

参考文献:10.1124/mol.119.115964
摘要:Lee TD, Lee OW, Brimacombe KR, Chen L, Guha R, Lusvarghi S, Tebase BG, Klumpp-Thomas C, Robey RW, Ambudkar SV, Shen M, Gottesman MM, Hall MD. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular Pharmacology. 2019 Nov;96(5):629–40. doi: 10.1124/mol.119.115964.
参考文献:10.1007/s11481-019-09903-9
摘要:Hsu CC, Kuo TW, Liu WP, Chang CP, Lin HJ. Calycosin Preserves BDNF/TrkB Signaling and Reduces Post-Stroke Neurological Injury after Cerebral Ischemia by Reducing Accumulation of Hypertrophic and TNF-α-Containing Microglia in Rats. J Neuroimmune Pharmacol. 2020 Jun;15(2):326–39. doi: 10.1007/s11481-019-09903-9.