CAS: 200937-17-3; (R)-2-((Tert-Butoxycarbonyl)Amino)-4-Methylpentanoic Acid Hydrate

专利信息

专利号:US-11708341-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-((R)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof
发明人：Beaver Matthew; CUI SHENG; SHI XIANGQING
权利人:AMGEN INC
摘要:The present invention provides new methods for preparing compound 5, and pharmaceutically acceptable salts thereof, of structure n nCompound 5, or a pharmaceutically acceptable salt thereof, is an important intermediate in the synthesis of carfilzomib. The invention further provides methods of making a useful manganese catalyst that may be used in the epoxidation step of the present invention.

专利号:CN-109641863-B
优先权日:2016-08-05
标 题 :Synthesis of intermediates for the synthesis of carfilzomib and its pharmaceutically acceptable salts

专利号:EP-3494108-B1
优先权日:2016-08-05
标 题:Synthesis of (s)-2-amino-4-methyl-1-((r)-2-methyloxirane-2-yl)-pentan-1-one and pharmaceutically acceptable salts thereof

专利号:JP-7229912-B2
优先权日:2016-08-05
标题:Synthesis of (S)-2-amino-4-methyl-1-((R)-2-methyloxiran-2-yl)-pentan-1-one and its pharmaceutically acceptable salts

专利号:JP-2019525945-A
优先权日:2016-08-05
标题:Synthesis of (S) -2-amino-4-methyl-1-((R) -2-methyloxiran-2-yl) -pentan-1-one and pharmaceutically acceptable salts thereof

专利号:US-2021284617-A1
优先权日:2016-08-05
标题:Synthesis of (S)-2-Amino-4-Methyl-((R)-2-Methyloxirane-2-Yl)-Pentan-1-One and Pharmaceutically Acceptable Salts Thereof